MiR-4638-5p inhibits castration resistance of prostate cancer through repressing Kidins220 expression and PI3K/AKT pathway activity Article Swipe
Yang Wang
,
Ning Shao
,
Xueying Mao
,
Zhu Min-min
,
Weifei Fan
,
Zhixiang Shen
,
Rong Xiao
,
Chuncai Wang
,
Wenping Bao
,
Xinyu Xu
,
Chun Yang
,
Jian Dong
,
Deshui Yu
,
Yan Wu
,
Caixia Zhu
,
Liting Wen
,
Xiaojie Lu
,
Yong‐Jie Lu
,
Ninghan Feng
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.10165
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.10165
MicroRNAs (miRNAs) are short, conserved segments of non-coding RNA which play a significant role in prostate cancer development and progression. To identify miRNAs associated with castration resistance, we performed miRNA microarray analysis comparing castration resistant prostate cancer (CRPC) with androgen dependent prostate cancer (ADPC). We identified common underexpression of miR-4638-5p in CRPC compared to ADPC samples, which were further confirmed by quantitative PCR analysis. The role of miR-4638-5p in prostate cancer androgen-independent growth has been demonstrated both in vitro and in vivo. We also identified Kidins220 as a target gene directly regulated by miR-4638-5p and shRNA-mediated knockdown of Kidins220 phenocopied miR-4638-5p restoration. Subsequently, we revealed that Kidins220 activates PI3K/AKT pathway, which plays a key role in CRPC. Loss of miR- 4638-5p may lead to CRPC through the activity of Kidins220 and PI3K/AKT pathway. Furthermore, we found that miR-4638-5p, through regulating Kidins220 and the downstream activity of VEGF and PI3K/AKT pathway, influences prostate cancer progression via angiogenesis. The identification of miR-4638-5p down-regulation in CRPC and the understanding of the functional role of miR-4638-5p and its downstream genes/pathways have the potential to develop biomarkers for CRPC onset and to identify novel targets for novel forms of treatments of this lethal form of PCa.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/oncotarget.10165
- http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10165&path%5B%5D=31990
- OA Status
- diamond
- Cited By
- 32
- References
- 87
- Related Works
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- OpenAlex ID
- https://openalex.org/W2431396219
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2431396219Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.18632/oncotarget.10165Digital Object Identifier
- Title
-
MiR-4638-5p inhibits castration resistance of prostate cancer through repressing Kidins220 expression and PI3K/AKT pathway activityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-06-18Full publication date if available
- Authors
-
Yang Wang, Ning Shao, Xueying Mao, Zhu Min-min, Weifei Fan, Zhixiang Shen, Rong Xiao, Chuncai Wang, Wenping Bao, Xinyu Xu, Chun Yang, Jian Dong, Deshui Yu, Yan Wu, Caixia Zhu, Liting Wen, Xiaojie Lu, Yong‐Jie Lu, Ninghan FengList of authors in order
- Landing page
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https://doi.org/10.18632/oncotarget.10165Publisher landing page
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https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10165&path%5B%5D=31990Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
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https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10165&path%5B%5D=31990Direct OA link when available
- Concepts
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Prostate cancer, Medicine, PI3K/AKT/mTOR pathway, microRNA, Oncology, Gynecology, Protein kinase B, Internal medicine, Cancer, Cancer research, Angiogenesis, Gene, Apoptosis, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
32Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2023: 6, 2022: 2, 2021: 4, 2020: 3Per-year citation counts (last 5 years)
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87Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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