MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2 Article Swipe
Henan Zhao
,
Xiaotang Yu
,
Yanfang Ding
,
Jinyao Zhao
,
Guang Wang
,
Xian Wu
,
Jiyong Jiang
,
Chun Peng
,
Gordon Guo
,
Shiying Cui
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.10736
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.10736
In this study, we examined the role of the miRNA miR-770-5p in cisplatin chemotherapy resistance in ovarian cancer (OVC) patients. miR-770-5p expression was reduced in platinum-resistant patients. Using a 6.128-fold in expression as the cutoff value, miR-770-5p expression served as a prognostic biomarker and predicted the response to cisplatin treatment and survival among OVC patients. Overexpression of miR-770-5p in vitro reduced survival in chemoresistant cell lines after cisplatin treatment. ERCC2, a target gene of miR-770-5p that participates in the NER system, was negatively regulated by miR-770-5p. siRNA-mediated silencing of ERCC2 reversed the inhibition of apoptosis resulting from miR-770-5p downreglation in A2780S cells. A comet assay confirmed that this restoration of cisplatin chemosensitivity was due to the inhibition of DNA repair. These findings suggest that endogenous miR-770-5p may function as an anti-oncogene and promote chemosensitivity in OVC, at least in part by downregulating ERCC2. miR-770-5p may therefore be a useful biomarker for predicting chemosensitivity to cisplatin in OVC patients and improve the selection of effective, more personalized, treatment strategies.
Related Topics
Concepts
Cisplatin
ERCC2
Medicine
Ovarian cancer
Cancer research
microRNA
Oncology
Gene silencing
Olaparib
Chemotherapy
ERCC1
Cancer
DNA repair
Internal medicine
Nucleotide excision repair
Biology
Gene
Genetics
Poly ADP ribose polymerase
Polymerase
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/oncotarget.10736
- http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10736&path%5B%5D=33990
- OA Status
- diamond
- Cited By
- 76
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2486971379
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2486971379Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.18632/oncotarget.10736Digital Object Identifier
- Title
-
MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-07-20Full publication date if available
- Authors
-
Henan Zhao, Xiaotang Yu, Yanfang Ding, Jinyao Zhao, Guang Wang, Xian Wu, Jiyong Jiang, Chun Peng, Gordon Guo, Shiying CuiList of authors in order
- Landing page
-
https://doi.org/10.18632/oncotarget.10736Publisher landing page
- PDF URL
-
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10736&path%5B%5D=33990Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=10736&path%5B%5D=33990Direct OA link when available
- Concepts
-
Cisplatin, ERCC2, Medicine, Ovarian cancer, Cancer research, microRNA, Oncology, Gene silencing, Olaparib, Chemotherapy, ERCC1, Cancer, DNA repair, Internal medicine, Nucleotide excision repair, Biology, Gene, Genetics, Poly ADP ribose polymerase, PolymeraseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
76Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 4, 2023: 10, 2022: 5, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2169332120, https://openalex.org/W2069556083, https://openalex.org/W2113629984, https://openalex.org/W2328421677, https://openalex.org/W1981857133, https://openalex.org/W1998258610, https://openalex.org/W2053132317, https://openalex.org/W2095569721, https://openalex.org/W1982104257, https://openalex.org/W1775562748, https://openalex.org/W1987459099, https://openalex.org/W2093905827, https://openalex.org/W2112344373, https://openalex.org/W2007118283, https://openalex.org/W1986348063, https://openalex.org/W2036223578, https://openalex.org/W2109449896, https://openalex.org/W1997261348, https://openalex.org/W2120717946, https://openalex.org/W2160953558, https://openalex.org/W1973096044, https://openalex.org/W2136201440, https://openalex.org/W2581193880, https://openalex.org/W2165042129, https://openalex.org/W2058279966, https://openalex.org/W2077594563, https://openalex.org/W2007458878, https://openalex.org/W1975765571, https://openalex.org/W2032299413, https://openalex.org/W2167805334, https://openalex.org/W2990354009, https://openalex.org/W1935237200, https://openalex.org/W2070555046, https://openalex.org/W2001168282, https://openalex.org/W1967047299, https://openalex.org/W2007205390, https://openalex.org/W2040906924, https://openalex.org/W2004174653, https://openalex.org/W2999391015, https://openalex.org/W2095033674 |
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