miR‐106b‐5p promotes aggressive progression of hepatocellular carcinoma via targeting RUNX3 Article Swipe
Hao Gu
,
Shensen Gu
,
Xinlong Zhang
,
Song-Jiang Zhang
,
Dongming Zhang
,
Jun Lin
,
Saiken Hasengbayi
,
Wei Han
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/cam4.2511
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/cam4.2511
Background and Objectives The roles of microRNA(miR)‐106b‐5p in hepatocellular carcinoma (HCC) remain unclear. We aimed here to investigate the clinical significance of miR‐106b‐5p expression in HCC and its underlying mechanisms. Methods Expression levels of miR‐106b‐5p in 108 HCC clinical samples by quantitative real‐time reverse transcription PCR. Associations of miR‐106b‐5p expression with various clinicopathological features and patients' prognosis were evaluated by Chi‐square test, Kaplan‐Meier, and Cox proportional regression analyses, respectively. The target gene of miR‐106b‐5p and their functions in HCC cells were investigated by luciferase reporter, CCK‐8, and Transwell Matrigel invasion assays. Results miR‐106b‐5p expression was markedly higher in HCC tissues than in noncancerous adjacent liver tissues ( P < .001). miR‐106b‐5p upregulation was significantly associated with advanced TNM stage ( P = .02), short recurrence‐free ( P = .005), and overall ( P = .001) survivals. Importantly, miR‐106b‐5p expression was an independent predictor of poor prognosis ( P < .05). RUNX3 was identified as a direct target gene of miR‐106b‐5p in HCC cells. Functionally, miR‐106b‐5p upregulation promoted the viability and invasion of HCC cells, while enforced RUNX3 expression reversed the oncogenic effects of miR‐106b‐5p overexpression. Conclusions miR‐106b‐5p may serve as a potent prognostic marker for tumor recurrence and survival of HCC patients. miR‐106b‐5p may exert an oncogenic role in HCC via regulating its target gene RUNX3.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cam4.2511
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2511
- OA Status
- gold
- Cited By
- 39
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2972782324
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2972782324Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/cam4.2511Digital Object Identifier
- Title
-
miR‐106b‐5p promotes aggressive progression of hepatocellular carcinoma via targeting RUNX3Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-09-10Full publication date if available
- Authors
-
Hao Gu, Shensen Gu, Xinlong Zhang, Song-Jiang Zhang, Dongming Zhang, Jun Lin, Saiken Hasengbayi, Wei HanList of authors in order
- Landing page
-
https://doi.org/10.1002/cam4.2511Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2511Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.2511Direct OA link when available
- Concepts
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Hepatocellular carcinoma, Downregulation and upregulation, Matrigel, microRNA, Cancer research, Medicine, Reporter gene, Proportional hazards model, Gene expression, Internal medicine, Oncology, Gene, Biology, Angiogenesis, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
39Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 5, 2023: 2, 2022: 4, 2021: 13Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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