Mitigation of Hepatic Impairment with Polysaccharides from Red Alga <em>Alsidium corallinum</em> Supplementation through Promoting the Lipid Profile and Liver Homeostasis in Tebuconazole-Exposed Rats Article Swipe
Hajer Ben Saad
,
Donyez Frikha-Dammak
,
Amir Bouallegue
,
Riadh Badraoui
,
Manel Mellouli
,
Hatem Kallel
,
Jean Marc Pujo
,
Ibtissem Ben Amara
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202308.1842.v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202308.1842.v1
Sulfated polysaccharides from seaweed are highly active natural substances having valuable applications. In the present paper, attempts have been made to discuss the physicochemical and structural features of polysaccharides isolated from red marine alga Alsidium corallinum (ACPs) and its protective effect in hepatic impairments induced by tebuconazole (TBZ) in rats. Structural features were determined using High performance liquid chromatography, Fourier transformed infrared, and solid state 1H and 13C-Nuclear magnetic resonance analysis. ACPs are found to be hetero-sulfated-anionic polysaccharides that contained carbohydrates, sulfate groups and uronic acids. In vitro biological activities suggested the effective antioxidant and antimicrobial capacities of ACPs. For antioxidant testing in vivo, the biochemical analysis and plasma profiles displayed that oral administration of ACPs could mitigate blood lipid indicators, including total cholesterol, triglyceride, low and high density lipoprotein cholesterol, bilirubin, liver function indexes involving alanine aminotransferase and aspartate aminotransferase, showed that ACPs possessed obvious antioxidant activities. Besides, the intervention of ACPs potentially inhibited lipid peroxidation, protein oxidation, key enzymes of lipid metabolism (<0.001) and increased levels and antioxidant status (<0.05). Histomorphological observation confirmed that ACPs intervention could partially repair liver injuries caused by TBZ. The computational results showed that A. corallinum monosaccharides bound 1JIJ, 1HD2 and 1WL4 receptors with acceptable affinities, which together with deep embedding and molecular interactions support the antioxidant, antimicrobial and hypolipidemic outlined effects in the in vitro and in vivo findings. In view of their prominent antioxidant effects, ACPs stand for promising candidates in liver diseases and need be considered in pharmaceutical applications.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202308.1842.v1
- https://www.preprints.org/manuscript/202308.1842/v1/download
- OA Status
- green
- Cited By
- 8
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386252856
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386252856Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.20944/preprints202308.1842.v1Digital Object Identifier
- Title
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Mitigation of Hepatic Impairment with Polysaccharides from Red Alga <em>Alsidium corallinum</em> Supplementation through Promoting the Lipid Profile and Liver Homeostasis in Tebuconazole-Exposed RatsWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-08-28Full publication date if available
- Authors
-
Hajer Ben Saad, Donyez Frikha-Dammak, Amir Bouallegue, Riadh Badraoui, Manel Mellouli, Hatem Kallel, Jean Marc Pujo, Ibtissem Ben AmaraList of authors in order
- Landing page
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https://doi.org/10.20944/preprints202308.1842.v1Publisher landing page
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https://www.preprints.org/manuscript/202308.1842/v1/downloadDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.preprints.org/manuscript/202308.1842/v1/downloadDirect OA link when available
- Concepts
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Antioxidant, Lipid peroxidation, Polysaccharide, Biochemistry, Monosaccharide, Chemistry, In vivo, Liver function, Pharmacology, Biology, Internal medicine, Medicine, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
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8Total citation count in OpenAlex
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2025: 4, 2024: 1, 2023: 3Per-year citation counts (last 5 years)
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62Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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