Mitochondria Organelle Transplantation: “A Potential Cellular Biotherapy for Cancer” Article Swipe
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· 2015
· Open Access
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· DOI: https://doi.org/10.13188/2332-4139.s200006
· OA: W4245775278
Mitochondrial dysfunction is implicated in many human diseases including metabolic, ageing, cancer, cardiovascular and neurodegenerative.In the 1930's Warburg demonstrated that defective mitochondrial respiration altered tumor cell metabolism.He noticed a shift to glycolysis with a marked increase in lactate production in the presence of oxygen without an increase in oxidative phosphorylation.This effect of aerobic glycolysis became known as the "Warburg Effect" and as a possible initiating step in tumorigenesis.We have supported Warburg's theory of mitochondrial dysfunction in tumorigenesis by transplanting normal isolated mitochondria into cancer cells.The mitochondria organelle transfer (MOT) decreased proliferation, lactate production, and increased drug sensitivity of the cancer cells.Others have shown that cellular uptake of exogenous mitochondria has restored functional recovery of defective recipient cells.In our study organelle transfer was confirmed by confocal and fluorescent microscopy.In conclusion, the transfer of isolated normal exogenous mitochondria into diseased human cells is postulated as a mechanism of cell based therapy. Research perspectiveAfter reviewing the past and the marvelous work of Otto Warburg, we now need to fast forward and study the great work of Thomas Seyfried.He and Shelton have published a great paper on cancer as a metabolic disease [4], and Seyfried's book "Cancer as a Metabolic Disease" has been released by Wiley" [5].Seyfried points out in both that only those body cells able to increase glycolysis during intermittent respiratory damage are capable of promoting tumorigenesis, Cells unable to induce glycolysis in response to respiratory damage will perish due to energy failure.Though aware
