Molecular Metabolism • Vol 20
Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing
November 2018 • Lucie Desmoulins, Chloé Chrétien, Romain Paccoud, Stephan C. Collins, Céline Cruciani‐Guglielmacci, Anne Galinier, Fabienne Liénard, Aurore Quinault,…
A hypothalamic alteration of DRP1-induced fission and mROS signaling in response to glucose was observed in HGS-induced IS of rats exposed to a 3 week HFHS diet. Early hypothalamic modifications of the neuronal activity could participate in a primary defect of the control of IS and ultimately, the development of diabetes.