Mitochondrial dysfunction in metabolic disorders induced by per- and polyfluoroalkyl substance mixtures in zebrafish larvae Article Swipe
Yingxin Liu
,
Shuai Liu
,
Jing Huang
,
Yu Liu
,
Qiyu Wang
,
Jinyuan Chen
,
Liwei Sun
,
Wenqing Tu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.envint.2023.107977
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.envint.2023.107977
Several per- and polyfluoroalkyl substances (PFAS) have been linked to metabolic disorders in organisms. However, few studies have considered their combined effects, which would be more representative of PFAS occurring in the environment. In this study, zebrafish embryos were exposed to a mixture of 18 PFAS at three environmentally relevant concentrations for 5 days to assess their bioconcentration and metabolic consequences. The burdens of ∑PFAS in zebrafish larvae were 0.12, 1.58, and 9.63 mg/kg in the 0.5, 5, and 50 μg/L treatment groups, respectively. Exposure to the PFAS mixture accelerated hatching and larval heart rates, increased energy expenditure, and reduced ATP levels and glucose contents due to decreased feed intake and glucose uptake. Metabolomic analysis revealed that exposure to the PFAS mixture enhanced glycolysis but inhibited phospholipid synthesis, and significantly increased the expression of lipid metabolism related genes (srebf1, acox, and pparα), which indicated enhanced β-oxidation. The significant changes in mitochondrial membrane potential, mitochondrial content, and the transcription of genes involved in the mitochondrial respiratory chain (mfn2, ndufs1, atp5fa1, and mt-nd1) and mitochondrial DNA replication and transcription (18rs-rrn, and polg1) suggested that exposure to the PFAS mixture could cause mitochondrial dysfunction and further disrupt glucose and lipid metabolic pathways, ultimately causing metabolic disorders in zebrafish larvae. These findings demonstrate the importance of assessing the metabolic effects of PFAS mixtures on early development in wildlife and humans.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.envint.2023.107977
- OA Status
- gold
- Cited By
- 53
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4376602230Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.envint.2023.107977Digital Object Identifier
- Title
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Mitochondrial dysfunction in metabolic disorders induced by per- and polyfluoroalkyl substance mixtures in zebrafish larvaeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-15Full publication date if available
- Authors
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Yingxin Liu, Shuai Liu, Jing Huang, Yu Liu, Qiyu Wang, Jinyuan Chen, Liwei Sun, Wenqing TuList of authors in order
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https://doi.org/10.1016/j.envint.2023.107977Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.envint.2023.107977Direct OA link when available
- Concepts
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Zebrafish, Biology, Metabolic pathway, Mitochondrion, Bioenergetics, Glycolysis, Metabolism, Lipid metabolism, Mitochondrial DNA, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
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53Total citation count in OpenAlex
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2025: 26, 2024: 25, 2023: 2Per-year citation counts (last 5 years)
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66Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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