Mitochondrial Effects in the Liver of C57BL/6 Mice by Low Dose, High Energy, High Charge Irradiation Article Swipe
Brooke L. Barnette
,
Yongjia Yu
,
Robert L. Ullrich
,
Mark R. Emmett
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms222111806
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/ijms222111806
Galactic cosmic rays are primarily composed of protons (85%), helium (14%), and high charge/high energy ions (HZEs) such as 56Fe, 28Si, and 16O. HZE exposure is a major risk factor for astronauts during deep-space travel due to the possibility of HZE-induced cancer. A systems biology integrated omics approach encompassing transcriptomics, proteomics, lipidomics, and functional biochemical assays was used to identify microenvironmental changes induced by HZE exposure. C57BL/6 mice were placed into six treatment groups and received the following irradiation treatments: 600 MeV/n 56Fe (0.2 Gy), 1 GeV/n 16O (0.2 Gy), 350 MeV/n 28Si (0.2 Gy), 137Cs (1.0 Gy) gamma rays, 137Cs (3.0 Gy) gamma rays, and sham irradiation. Left liver lobes were collected at 30, 60, 120, 270, and 360 days post-irradiation. Analysis of transcriptomic and proteomic data utilizing ingenuity pathway analysis identified multiple pathways involved in mitochondrial function that were altered after HZE irradiation. Lipids also exhibited changes that were linked to mitochondrial function. Molecular assays for mitochondrial Complex I activity showed significant decreases in activity after HZE exposure. HZE-induced mitochondrial dysfunction suggests an increased risk for deep space travel. Microenvironmental and pathway analysis as performed in this research identified possible targets for countermeasures to mitigate risk.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms222111806
- https://www.mdpi.com/1422-0067/22/21/11806/pdf?version=1635756816
- OA Status
- gold
- Cited By
- 7
- References
- 62
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W3208271603Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms222111806Digital Object Identifier
- Title
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Mitochondrial Effects in the Liver of C57BL/6 Mice by Low Dose, High Energy, High Charge IrradiationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-10-30Full publication date if available
- Authors
-
Brooke L. Barnette, Yongjia Yu, Robert L. Ullrich, Mark R. EmmettList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms222111806Publisher landing page
- PDF URL
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https://www.mdpi.com/1422-0067/22/21/11806/pdf?version=1635756816Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/22/21/11806/pdf?version=1635756816Direct OA link when available
- Concepts
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Irradiation, Transcriptome, Mitochondrion, Nuclear medicine, Radiochemistry, Biology, Chemistry, Cancer research, Medicine, Physics, Cell biology, Biochemistry, Gene, Gene expression, Nuclear physicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2024: 2, 2022: 5Per-year citation counts (last 5 years)
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62Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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