Modeling human skeletal development using human pluripotent stem cells Article Swipe
Shireen R. Lamandé
,
Elizabeth S. Ng
,
Trevor L. Cameron
,
Louise H. W. Kung
,
Lisa Sampurno
,
Lynn Rowley
,
Jinia Lilianty
,
Yudha Nur Patria
,
Tayla Stenta
,
Eric Hanssen
,
Katrina M. Bell
,
Ritika Saxena
,
Kathryn S. Stok
,
Edouard G. Stanley
,
Andrew G. Elefanty
,
John F. Bateman
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2211510120
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2211510120
Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will provide insights into skeletal development and genetic skeletal disorders and will generate cells for regenerative medicine applications. Here, we describe a method that directs iPSC-derived sclerotome to chondroprogenitors in 3D pellet culture then to articular chondrocytes or, alternatively, along the growth plate cartilage pathway to become hypertrophic chondrocytes that can transition to osteoblasts. Osteogenic organoids deposit and mineralize a collagen I extracellular matrix (ECM), mirroring in vivo endochondral bone formation. We have identified gene expression signatures at key developmental stages including chondrocyte maturation, hypertrophy, and transition to osteoblasts and show that this system can be used to model genetic cartilage and bone disorders.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2211510120
- OA Status
- green
- Cited By
- 56
- References
- 101
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4367626138Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1073/pnas.2211510120Digital Object Identifier
- Title
-
Modeling human skeletal development using human pluripotent stem cellsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-01Full publication date if available
- Authors
-
Shireen R. Lamandé, Elizabeth S. Ng, Trevor L. Cameron, Louise H. W. Kung, Lisa Sampurno, Lynn Rowley, Jinia Lilianty, Yudha Nur Patria, Tayla Stenta, Eric Hanssen, Katrina M. Bell, Ritika Saxena, Kathryn S. Stok, Edouard G. Stanley, Andrew G. Elefanty, John F. BatemanList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.2211510120Publisher landing page
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10175848/pdf/pnas.202211510.pdfDirect OA link when available
- Concepts
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Cell biology, Induced pluripotent stem cell, Cartilage, Endochondral ossification, Chondrocyte, Extracellular matrix, Regenerative medicine, Osteoblast, Biology, Stem cell, Chemistry, Anatomy, Embryonic stem cell, In vitro, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
56Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 22, 2024: 24, 2023: 9, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
101Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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