Modeling Recurrence in Idiopathic Subglottic Stenosis With Mobile Peak Expiratory Flow Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.1002/lary.29760
Objectives/Hypothesis We sought to establish normative peak expiratory flow (PEF) data for patients with idiopathic subglottic stenosis (iSGS), evaluate whether immediate changes in PEF after a procedure predict long‐term treatment response, and test if a decline in longitudinal PEF is associated with disease recurrence. Study Design International, prospective, 3‐year multicenter cohort study of 810 patients with untreated, newly diagnosed, or previously treated iSGS. Methods iSGS patients consented and enrolled in the North American Airway Collaborative (NoAAC) iSGS 1000 cohort recorded PEF data on a mobile smartphone app. Cox regression tested the associations between the magnitude of postoperative PEF improvement and longitudinal 90‐day PEF decline with the risk of disease recurrence. Results Within the NoAAC iSGS 1000 cohort, 810 patients participated in a 3‐year prospective study comparing surgical treatment efficacy and 385 had appropriate PEF measurements and follow‐up data. Of those patients, 42% (161/385) required at least one operation during study follow‐up. The mean PEF preceding operative intervention was 241 L/min (95% confidence interval [CI]: 120–380) corresponding to a predicted PEF of 52%. The mean increase in PEF following a procedure was 111 L/min (95% CI: 96–125 L/min). Interestingly, the magnitude of immediate PEF improvement was not predictive of disease recurrence (hazard ratio [HR] for 100 L/min increase = 0.90, 95% CI: 0.60–1.00). However, recurrence was associated with the magnitude of PEF decline over 90 days (30% vs. 10% decline, HR = 2.2, 95% CI: 1.5–3.0). Conclusions We provide normative PEF data on a large iSGS patient cohort. The degree of PEF improvement immediately after surgery was not associated with a longer procedure‐free interval. However, a 30% decline in PEF over 90 days was associated with elevated risk of disease recurrence. Level of Evidence 2 Laryngoscope , 131:E2841–E2848, 2021
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/lary.29760
- OA Status
- green
- Cited By
- 14
- References
- 16
- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3186398038Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/lary.29760Digital Object Identifier
- Title
-
Modeling Recurrence in Idiopathic Subglottic Stenosis With Mobile Peak Expiratory FlowWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
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2021-07-26Full publication date if available
- Authors
-
Kyle S. Kimura, Liping Du, Lynn D. Berry, Li‐Ching Huang, Sheau‐Chiann Chen, David O. Francis, Alexander GelbardList of authors in order
- Landing page
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https://doi.org/10.1002/lary.29760Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/8595545Direct OA link when available
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Medicine, Hazard ratio, Proportional hazards model, Prospective cohort study, Cohort, Confidence interval, Internal medicine, Cohort studyTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 4, 2024: 5, 2023: 3, 2022: 2Per-year citation counts (last 5 years)
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16Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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