Modelling the association between neutralizing antibody levels and SARS-CoV-2 viral dynamics : implications to define correlates of protection against infection Article Swipe
YOU?
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· 2023
· Open Access
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· DOI: https://doi.org/10.1101/2023.03.05.23286816
Background While anti-SARS-CoV-2 antibody kinetics have been well described in large populations of vaccinated individuals, we still poorly understand how they evolve during a natural infection and how this impacts viral clearance. Methods For that purpose, we analyzed the kinetics of both viral load and neutralizing antibody levels in a prospective cohort of individuals during acute infection by Alpha variant. Results Using a mathematical model, we show that the progressive increase in neutralizing antibodies leads to a shortening of the half-life of both infected cells and infectious viral particles. We estimated that the neutralizing activity reached 90% of its maximal level within 8 days after symptoms onset and could reduce the half-life of both infected cells and infectious virus by a 6-fold factor, thus playing a key role to achieve rapid viral clearance. Using this model, we conducted a simulation study to predict in a more general context the protection conferred by the existence of pre-existing neutralization, due to either vaccination or prior infection. We predicted that a neutralizing activity, as measured by ED 50 >10 3 , could reduce by 50% the risk of having viral load detectable by standard PCR assays and by 99% the risk of having viral load above the threshold of cultivable virus. Conclusions This threshold value for the neutralizing activity could be used to identify individuals with poor protection against disease acquisition.
Related Topics
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.03.05.23286816
- https://www.medrxiv.org/content/medrxiv/early/2023/03/06/2023.03.05.23286816.full.pdf
- OA Status
- green
- Cited By
- 4
- References
- 19
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4323536487Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.03.05.23286816Digital Object Identifier
- Title
-
Modelling the association between neutralizing antibody levels and SARS-CoV-2 viral dynamics : implications to define correlates of protection against infectionWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-06Full publication date if available
- Authors
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Guillaume Lingas, Delphine Planas, Hélène Péré, Darragh Duffy, Isabelle Staropoli, Françoise Porrot, Florence Guivel‐Benhassine, Nicolas Chapuis, Camille Gobeaux, David Veyer, Constance Delaugerre, Jérôme Le Goff, Prunelle Getten, Jérôme Hadjadj, Adèle Bellino, Béatrice Parfait, Jean‐Marc Tréluyer, Olivier Schwartz, Jérémie Guedj, Solen Kernéis, Benjamin TerrierList of authors in order
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https://doi.org/10.1101/2023.03.05.23286816Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2023/03/06/2023.03.05.23286816.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2023/03/06/2023.03.05.23286816.full.pdfDirect OA link when available
- Concepts
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Viral load, Neutralizing antibody, Virology, Antibody, Neutralization, Context (archaeology), Immunology, Vaccination, Virus, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Biology, Medicine, Infectious disease (medical specialty), Coronavirus disease 2019 (COVID-19), Disease, Internal medicine, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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19Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W3126652124, https://openalex.org/W3217549965, https://openalex.org/W3163785571, https://openalex.org/W4283709513, https://openalex.org/W4281296819, https://openalex.org/W4221072241, https://openalex.org/W4286615180, https://openalex.org/W4220970752, https://openalex.org/W3190959266, https://openalex.org/W3134845538, https://openalex.org/W3057728496, https://openalex.org/W4205577126, https://openalex.org/W3139074260, https://openalex.org/W4206142017, https://openalex.org/W4210933002, https://openalex.org/W3035973582, https://openalex.org/W4210773661, https://openalex.org/W4302009688, https://openalex.org/W4206969180 |
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| corresponding_author_ids | https://openalex.org/A5080451499 |
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