Moderate‐ and High‐Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon Article Swipe
Margaret K. Tamburro
,
Kelsey Bonilla
,
Snehal S. Shetye
,
Thomas Leahy
,
Jeremy D. Eekhoff
,
Min Soo Kim
,
Christopher Petucci
,
John W. Tobias
,
Daniel C. Farber
,
Louis J. Soslowsky
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/jor.26030
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/jor.26030
Exercise influences clinical Achilles tendon health in humans, but animal models of exercise‐related Achilles tendon changes are lacking. Moreover, previous investigations of the effects of treadmill running exercise on rat Achilles tendon demonstrate variable outcomes. Our objective was to assess the functional, structural, cellular, and biomechanical impacts of treadmill running exercise on rat Achilles tendon with sensitive in and ex vivo approaches. Three running levels were assessed over the course of 8 weeks: control (cage activity), moderate‐speed (treadmill running at 10 m/min, no incline), and high‐speed (treadmill running at 20 m/min, 10° incline). We hypothesized that moderate‐speed treadmill running would beneficially impact tendon biomechanics through increased tenocyte cellularity, metabolism, and anabolism whereas high‐speed treadmill running would cause a tendinopathic phenotype with compromised tendon biomechanics due to pathologic tenocyte differentiation, metabolism, and catabolism. Contrary to our hypothesis, treadmill running exercise at these speeds had a nominal effect on the rat Achilles tendon. Treadmill running modestly influenced tenocyte metabolism and nuclear aspect ratio as well as viscoelastic tendon properties but did not cause a tendinopathic phenotype. These findings highlight the need for improved models of exercise‐ and loading‐related tendon changes that can be leveraged to develop strategies for tendinopathy prevention and treatment.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jor.26030
- OA Status
- green
- Cited By
- 2
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405854153
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4405854153Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jor.26030Digital Object Identifier
- Title
-
Moderate‐ and High‐Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles TendonWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-27Full publication date if available
- Authors
-
Margaret K. Tamburro, Kelsey Bonilla, Snehal S. Shetye, Thomas Leahy, Jeremy D. Eekhoff, Min Soo Kim, Christopher Petucci, John W. Tobias, Daniel C. Farber, Louis J. SoslowskyList of authors in order
- Landing page
-
https://doi.org/10.1002/jor.26030Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11806652Direct OA link when available
- Concepts
-
Achilles tendon, Treadmill, Tendinopathy, Tendon, Biomechanics, Medicine, Physical medicine and rehabilitation, Physical therapy, Surgery, AnatomyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4405854153 |
|---|---|
| doi | https://doi.org/10.1002/jor.26030 |
| ids.doi | https://doi.org/10.1002/jor.26030 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39731286 |
| ids.openalex | https://openalex.org/W4405854153 |
| fwci | 2.07388028 |
| mesh[0].qualifier_ui | Q000502 |
| mesh[0].descriptor_ui | D000125 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | physiology |
| mesh[0].descriptor_name | Achilles Tendon |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000818 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Animals |
| mesh[2].qualifier_ui | Q000502 |
| mesh[2].descriptor_ui | D012420 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | physiology |
| mesh[2].descriptor_name | Running |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D010805 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Physical Conditioning, Animal |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D017207 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Rats, Sprague-Dawley |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D001696 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Biomechanical Phenomena |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D008297 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Male |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D051381 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Rats |
| mesh[8].qualifier_ui | Q000502 |
| mesh[8].descriptor_ui | D000070916 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | physiology |
| mesh[8].descriptor_name | Tenocytes |
| mesh[9].qualifier_ui | Q000502 |
| mesh[9].descriptor_ui | D000125 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | physiology |
| mesh[9].descriptor_name | Achilles Tendon |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D000818 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Animals |
| mesh[11].qualifier_ui | Q000502 |
| mesh[11].descriptor_ui | D012420 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | physiology |
| mesh[11].descriptor_name | Running |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D010805 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Physical Conditioning, Animal |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D017207 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Rats, Sprague-Dawley |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D001696 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Biomechanical Phenomena |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D008297 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Male |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D051381 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Rats |
| mesh[17].qualifier_ui | Q000502 |
| mesh[17].descriptor_ui | D000070916 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | physiology |
| mesh[17].descriptor_name | Tenocytes |
| mesh[18].qualifier_ui | Q000502 |
| mesh[18].descriptor_ui | D000125 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | physiology |
| mesh[18].descriptor_name | Achilles Tendon |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D000818 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Animals |
| mesh[20].qualifier_ui | Q000502 |
| mesh[20].descriptor_ui | D012420 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | physiology |
| mesh[20].descriptor_name | Running |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D010805 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Physical Conditioning, Animal |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D017207 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Rats, Sprague-Dawley |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D001696 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Biomechanical Phenomena |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D008297 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Male |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D051381 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Rats |
| mesh[26].qualifier_ui | Q000502 |
| mesh[26].descriptor_ui | D000070916 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | physiology |
| mesh[26].descriptor_name | Tenocytes |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D000818 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Animals |
| mesh[28].qualifier_ui | Q000502 |
| mesh[28].descriptor_ui | D000125 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | physiology |
| mesh[28].descriptor_name | Achilles Tendon |
| mesh[29].qualifier_ui | Q000502 |
| mesh[29].descriptor_ui | D010805 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | physiology |
| mesh[29].descriptor_name | Physical Conditioning, Animal |
| mesh[30].qualifier_ui | Q000502 |
| mesh[30].descriptor_ui | D012420 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | physiology |
| mesh[30].descriptor_name | Running |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D001696 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Biomechanical Phenomena |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D051381 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Rats |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D017207 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Rats, Sprague-Dawley |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D008297 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Male |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D000070916 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | Tenocytes |
| type | article |
| title | Moderate‐ and High‐Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon |
| biblio.issue | 3 |
| biblio.volume | 43 |
| biblio.last_page | 530 |
| biblio.first_page | 519 |
| topics[0].id | https://openalex.org/T11068 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2732 |
| topics[0].subfield.display_name | Orthopedics and Sports Medicine |
| topics[0].display_name | Tendon Structure and Treatment |
| topics[1].id | https://openalex.org/T11246 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9955000281333923 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2732 |
| topics[1].subfield.display_name | Orthopedics and Sports Medicine |
| topics[1].display_name | Sports injuries and prevention |
| topics[2].id | https://openalex.org/T10280 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9914000034332275 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2746 |
| topics[2].subfield.display_name | Surgery |
| topics[2].display_name | Shoulder Injury and Treatment |
| funders[0].id | https://openalex.org/F4320337362 |
| funders[0].ror | https://ror.org/006zn3t30 |
| funders[0].display_name | National Institute of Arthritis and Musculoskeletal and Skin Diseases |
| is_xpac | False |
| apc_list.value | 3750 |
| apc_list.currency | USD |
| apc_list.value_usd | 3750 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2780984734 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8880338668823242 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q223172 |
| concepts[0].display_name | Achilles tendon |
| concepts[1].id | https://openalex.org/C2781464450 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7957955598831177 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q839144 |
| concepts[1].display_name | Treadmill |
| concepts[2].id | https://openalex.org/C2778911562 |
| concepts[2].level | 3 |
| concepts[2].score | 0.7091938257217407 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1682583 |
| concepts[2].display_name | Tendinopathy |
| concepts[3].id | https://openalex.org/C2780105995 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6853979825973511 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q232358 |
| concepts[3].display_name | Tendon |
| concepts[4].id | https://openalex.org/C170700871 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6660090088844299 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q193378 |
| concepts[4].display_name | Biomechanics |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.5685842633247375 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C99508421 |
| concepts[6].level | 1 |
| concepts[6].score | 0.5680702328681946 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2678675 |
| concepts[6].display_name | Physical medicine and rehabilitation |
| concepts[7].id | https://openalex.org/C1862650 |
| concepts[7].level | 1 |
| concepts[7].score | 0.3513634502887726 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q186005 |
| concepts[7].display_name | Physical therapy |
| concepts[8].id | https://openalex.org/C141071460 |
| concepts[8].level | 1 |
| concepts[8].score | 0.1852460503578186 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q40821 |
| concepts[8].display_name | Surgery |
| concepts[9].id | https://openalex.org/C105702510 |
| concepts[9].level | 1 |
| concepts[9].score | 0.18475890159606934 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q514 |
| concepts[9].display_name | Anatomy |
| keywords[0].id | https://openalex.org/keywords/achilles-tendon |
| keywords[0].score | 0.8880338668823242 |
| keywords[0].display_name | Achilles tendon |
| keywords[1].id | https://openalex.org/keywords/treadmill |
| keywords[1].score | 0.7957955598831177 |
| keywords[1].display_name | Treadmill |
| keywords[2].id | https://openalex.org/keywords/tendinopathy |
| keywords[2].score | 0.7091938257217407 |
| keywords[2].display_name | Tendinopathy |
| keywords[3].id | https://openalex.org/keywords/tendon |
| keywords[3].score | 0.6853979825973511 |
| keywords[3].display_name | Tendon |
| keywords[4].id | https://openalex.org/keywords/biomechanics |
| keywords[4].score | 0.6660090088844299 |
| keywords[4].display_name | Biomechanics |
| keywords[5].id | https://openalex.org/keywords/medicine |
| keywords[5].score | 0.5685842633247375 |
| keywords[5].display_name | Medicine |
| keywords[6].id | https://openalex.org/keywords/physical-medicine-and-rehabilitation |
| keywords[6].score | 0.5680702328681946 |
| keywords[6].display_name | Physical medicine and rehabilitation |
| keywords[7].id | https://openalex.org/keywords/physical-therapy |
| keywords[7].score | 0.3513634502887726 |
| keywords[7].display_name | Physical therapy |
| keywords[8].id | https://openalex.org/keywords/surgery |
| keywords[8].score | 0.1852460503578186 |
| keywords[8].display_name | Surgery |
| keywords[9].id | https://openalex.org/keywords/anatomy |
| keywords[9].score | 0.18475890159606934 |
| keywords[9].display_name | Anatomy |
| language | en |
| locations[0].id | doi:10.1002/jor.26030 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S12558119 |
| locations[0].source.issn | 0736-0266, 1554-527X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0736-0266 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Orthopaedic Research® |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Orthopaedic Research |
| locations[0].landing_page_url | https://doi.org/10.1002/jor.26030 |
| locations[1].id | pmid:39731286 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of orthopaedic research : official publication of the Orthopaedic Research Society |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39731286 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11806652 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | J Orthop Res |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11806652 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5107327249 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2869-0886 |
| authorships[0].author.display_name | Margaret K. Tamburro |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I79576946 |
| authorships[0].affiliations[1].raw_affiliation_string | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[0].institutions[0].id | https://openalex.org/I79576946 |
| authorships[0].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of Pennsylvania |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Margaret K. Tamburro |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA, McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[1].author.id | https://openalex.org/A5023494358 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5381-5834 |
| authorships[1].author.display_name | Kelsey Bonilla |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[1].affiliations[0].raw_affiliation_string | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[1].institutions[0].id | https://openalex.org/I79576946 |
| authorships[1].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of Pennsylvania |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Kelsey A. Bonilla |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[2].author.id | https://openalex.org/A5004552135 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-7469-3039 |
| authorships[2].author.display_name | Snehal S. Shetye |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[2].affiliations[0].raw_affiliation_string | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[2].institutions[0].id | https://openalex.org/I79576946 |
| authorships[2].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of Pennsylvania |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Snehal S. Shetye |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[3].author.id | https://openalex.org/A5102941321 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-2749-6021 |
| authorships[3].author.display_name | Thomas Leahy |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[3].affiliations[0].raw_affiliation_string | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I79576946 |
| authorships[3].affiliations[1].raw_affiliation_string | Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[3].institutions[0].id | https://openalex.org/I79576946 |
| authorships[3].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of Pennsylvania |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Thomas P. Leahy |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA, McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[4].author.id | https://openalex.org/A5083353796 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-0494-2439 |
| authorships[4].author.display_name | Jeremy D. Eekhoff |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[4].affiliations[0].raw_affiliation_string | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[4].institutions[0].id | https://openalex.org/I79576946 |
| authorships[4].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of Pennsylvania |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jeremy D. Eekhoff |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[5].author.id | https://openalex.org/A5100394487 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-3322-9448 |
| authorships[5].author.display_name | Min Soo Kim |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Medicine, Perelman School of Medicine, Metabolomics Core, Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[5].institutions[0].id | https://openalex.org/I79576946 |
| authorships[5].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | University of Pennsylvania |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Min‐Soo Kim |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Medicine, Perelman School of Medicine, Metabolomics Core, Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[6].author.id | https://openalex.org/A5081359388 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Christopher Petucci |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Medicine, Perelman School of Medicine, Metabolomics Core, Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[6].institutions[0].id | https://openalex.org/I79576946 |
| authorships[6].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of Pennsylvania |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Christopher Petucci |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Medicine, Perelman School of Medicine, Metabolomics Core, Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[7].author.id | https://openalex.org/A5011609263 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-5362-7013 |
| authorships[7].author.display_name | John W. Tobias |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Medicine, Perelman School of Medicine, Penn Genomics and Sequencing Core, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[7].institutions[0].id | https://openalex.org/I79576946 |
| authorships[7].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of Pennsylvania |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | John W. Tobias |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Medicine, Perelman School of Medicine, Penn Genomics and Sequencing Core, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[8].author.id | https://openalex.org/A5036859110 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-4999-7038 |
| authorships[8].author.display_name | Daniel C. Farber |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[8].affiliations[0].raw_affiliation_string | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[8].institutions[0].id | https://openalex.org/I79576946 |
| authorships[8].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | University of Pennsylvania |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Daniel C. Farber |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[9].author.id | https://openalex.org/A5014456616 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-9325-7662 |
| authorships[9].author.display_name | Louis J. Soslowsky |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I79576946 |
| authorships[9].affiliations[0].raw_affiliation_string | McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I79576946 |
| authorships[9].affiliations[1].raw_affiliation_string | Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| authorships[9].institutions[0].id | https://openalex.org/I79576946 |
| authorships[9].institutions[0].ror | https://ror.org/00b30xv10 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I79576946 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | University of Pennsylvania |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Louis J. Soslowsky |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA, McKay Orthopaedic Laboratory, University of Pennsylvania, Philadelphia, Pennsylvania, USA |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11806652 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Moderate‐ and High‐Speed Treadmill Running Exercise Have Minimal Impact on Rat Achilles Tendon |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11068 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2732 |
| primary_topic.subfield.display_name | Orthopedics and Sports Medicine |
| primary_topic.display_name | Tendon Structure and Treatment |
| related_works | https://openalex.org/W1969774185, https://openalex.org/W2087830556, https://openalex.org/W1970368165, https://openalex.org/W4248936431, https://openalex.org/W4385707508, https://openalex.org/W2151367930, https://openalex.org/W2806566775, https://openalex.org/W1968272870, https://openalex.org/W1986706948, https://openalex.org/W2318797753 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:11806652 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | other-oa |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | https://openalex.org/licenses/other-oa |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | J Orthop Res |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11806652 |
| primary_location.id | doi:10.1002/jor.26030 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S12558119 |
| primary_location.source.issn | 0736-0266, 1554-527X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0736-0266 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Orthopaedic Research® |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Orthopaedic Research |
| primary_location.landing_page_url | https://doi.org/10.1002/jor.26030 |
| publication_date | 2024-12-27 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2165856921, https://openalex.org/W4211139874, https://openalex.org/W4386283505, https://openalex.org/W2008280378, https://openalex.org/W3021221396, https://openalex.org/W2055018900, https://openalex.org/W2183138426, https://openalex.org/W2136798324, https://openalex.org/W2794574658, https://openalex.org/W2078564732, https://openalex.org/W2026410358, https://openalex.org/W4403052475, https://openalex.org/W2016476456, https://openalex.org/W2802736960, https://openalex.org/W1976375878, https://openalex.org/W2066430956, https://openalex.org/W1979883047, https://openalex.org/W3217542384, https://openalex.org/W2112599232, https://openalex.org/W2207347746, https://openalex.org/W2605329153, https://openalex.org/W4388731879, https://openalex.org/W4311678929, https://openalex.org/W4322720015, https://openalex.org/W3196897371, https://openalex.org/W1988083689, https://openalex.org/W2061850933, https://openalex.org/W3047087098, https://openalex.org/W2036326461, https://openalex.org/W2005569210, https://openalex.org/W2115291512, https://openalex.org/W3016730115, https://openalex.org/W2921919452, https://openalex.org/W3127432761, https://openalex.org/W2057564766, https://openalex.org/W2097444304, https://openalex.org/W2090037368, https://openalex.org/W3214702501, https://openalex.org/W2267271212, https://openalex.org/W1981696974, https://openalex.org/W2752273860, https://openalex.org/W4213370965, https://openalex.org/W4364367499, https://openalex.org/W4321793630, https://openalex.org/W2083739396, https://openalex.org/W2347009382, https://openalex.org/W4205590320, https://openalex.org/W1986829884, https://openalex.org/W4324370133 |
| referenced_works_count | 49 |
| abstract_inverted_index.8 | 72 |
| abstract_inverted_index.a | 118, 144, 172 |
| abstract_inverted_index.10 | 81 |
| abstract_inverted_index.20 | 90 |
| abstract_inverted_index.We | 94 |
| abstract_inverted_index.as | 162, 164 |
| abstract_inverted_index.at | 80, 89, 140 |
| abstract_inverted_index.be | 191 |
| abstract_inverted_index.ex | 60 |
| abstract_inverted_index.in | 7, 58 |
| abstract_inverted_index.no | 83 |
| abstract_inverted_index.of | 12, 22, 25, 48, 71, 183 |
| abstract_inverted_index.on | 29, 52, 147 |
| abstract_inverted_index.to | 39, 126, 134, 193 |
| abstract_inverted_index.Our | 36 |
| abstract_inverted_index.and | 45, 59, 85, 110, 131, 158, 185, 199 |
| abstract_inverted_index.are | 17 |
| abstract_inverted_index.but | 9, 168 |
| abstract_inverted_index.can | 190 |
| abstract_inverted_index.did | 169 |
| abstract_inverted_index.due | 125 |
| abstract_inverted_index.for | 180, 196 |
| abstract_inverted_index.had | 143 |
| abstract_inverted_index.not | 170 |
| abstract_inverted_index.our | 135 |
| abstract_inverted_index.rat | 30, 53, 149 |
| abstract_inverted_index.the | 23, 41, 69, 148, 178 |
| abstract_inverted_index.was | 38 |
| abstract_inverted_index.10° | 92 |
| abstract_inverted_index.need | 179 |
| abstract_inverted_index.over | 68 |
| abstract_inverted_index.that | 96, 189 |
| abstract_inverted_index.vivo | 61 |
| abstract_inverted_index.well | 163 |
| abstract_inverted_index.were | 66 |
| abstract_inverted_index.with | 56, 121 |
| abstract_inverted_index.(cage | 75 |
| abstract_inverted_index.These | 175 |
| abstract_inverted_index.Three | 63 |
| abstract_inverted_index.cause | 117, 171 |
| abstract_inverted_index.ratio | 161 |
| abstract_inverted_index.these | 141 |
| abstract_inverted_index.would | 100, 116 |
| abstract_inverted_index.animal | 10 |
| abstract_inverted_index.aspect | 160 |
| abstract_inverted_index.assess | 40 |
| abstract_inverted_index.course | 70 |
| abstract_inverted_index.effect | 146 |
| abstract_inverted_index.health | 6 |
| abstract_inverted_index.impact | 102 |
| abstract_inverted_index.levels | 65 |
| abstract_inverted_index.m/min, | 82, 91 |
| abstract_inverted_index.models | 11, 182 |
| abstract_inverted_index.speeds | 142 |
| abstract_inverted_index.tendon | 5, 15, 32, 55, 103, 123, 166, 187 |
| abstract_inverted_index.weeks: | 73 |
| abstract_inverted_index.changes | 16, 188 |
| abstract_inverted_index.control | 74 |
| abstract_inverted_index.develop | 194 |
| abstract_inverted_index.effects | 24 |
| abstract_inverted_index.humans, | 8 |
| abstract_inverted_index.impacts | 47 |
| abstract_inverted_index.nominal | 145 |
| abstract_inverted_index.nuclear | 159 |
| abstract_inverted_index.running | 27, 50, 64, 79, 88, 99, 115, 138, 153 |
| abstract_inverted_index.tendon. | 151 |
| abstract_inverted_index.through | 105 |
| abstract_inverted_index.whereas | 112 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Achilles | 4, 14, 31, 54, 150 |
| abstract_inverted_index.Contrary | 133 |
| abstract_inverted_index.Exercise | 1 |
| abstract_inverted_index.assessed | 67 |
| abstract_inverted_index.clinical | 3 |
| abstract_inverted_index.exercise | 28, 51, 139 |
| abstract_inverted_index.findings | 176 |
| abstract_inverted_index.improved | 181 |
| abstract_inverted_index.lacking. | 18 |
| abstract_inverted_index.modestly | 154 |
| abstract_inverted_index.previous | 20 |
| abstract_inverted_index.tenocyte | 107, 128, 156 |
| abstract_inverted_index.variable | 34 |
| abstract_inverted_index.Moreover, | 19 |
| abstract_inverted_index.Treadmill | 152 |
| abstract_inverted_index.anabolism | 111 |
| abstract_inverted_index.cellular, | 44 |
| abstract_inverted_index.highlight | 177 |
| abstract_inverted_index.incline), | 84 |
| abstract_inverted_index.incline). | 93 |
| abstract_inverted_index.increased | 106 |
| abstract_inverted_index.leveraged | 192 |
| abstract_inverted_index.objective | 37 |
| abstract_inverted_index.outcomes. | 35 |
| abstract_inverted_index.phenotype | 120 |
| abstract_inverted_index.sensitive | 57 |
| abstract_inverted_index.treadmill | 26, 49, 98, 114, 137 |
| abstract_inverted_index.(treadmill | 78, 87 |
| abstract_inverted_index.activity), | 76 |
| abstract_inverted_index.influenced | 155 |
| abstract_inverted_index.influences | 2 |
| abstract_inverted_index.metabolism | 157 |
| abstract_inverted_index.pathologic | 127 |
| abstract_inverted_index.phenotype. | 174 |
| abstract_inverted_index.prevention | 198 |
| abstract_inverted_index.properties | 167 |
| abstract_inverted_index.strategies | 195 |
| abstract_inverted_index.treatment. | 200 |
| abstract_inverted_index.approaches. | 62 |
| abstract_inverted_index.catabolism. | 132 |
| abstract_inverted_index.compromised | 122 |
| abstract_inverted_index.demonstrate | 33 |
| abstract_inverted_index.exercise‐ | 184 |
| abstract_inverted_index.functional, | 42 |
| abstract_inverted_index.hypothesis, | 136 |
| abstract_inverted_index.metabolism, | 109, 130 |
| abstract_inverted_index.structural, | 43 |
| abstract_inverted_index.beneficially | 101 |
| abstract_inverted_index.biomechanics | 104, 124 |
| abstract_inverted_index.cellularity, | 108 |
| abstract_inverted_index.high‐speed | 86, 113 |
| abstract_inverted_index.hypothesized | 95 |
| abstract_inverted_index.tendinopathy | 197 |
| abstract_inverted_index.viscoelastic | 165 |
| abstract_inverted_index.biomechanical | 46 |
| abstract_inverted_index.tendinopathic | 119, 173 |
| abstract_inverted_index.investigations | 21 |
| abstract_inverted_index.differentiation, | 129 |
| abstract_inverted_index.moderate‐speed | 77, 97 |
| abstract_inverted_index.loading‐related | 186 |
| abstract_inverted_index.exercise‐related | 13 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5014456616 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I79576946 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.80808623 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |