Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting Article Swipe
YOU?
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· 2023
· Open Access
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· DOI: https://doi.org/10.1080/19490976.2023.2267180
The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled "Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans." Our Veteran patient population experiences a high incidence of service-related chronic physical and mental health problems, such as infection, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), various forms of hematological and non-hematological malignancies, neurologic conditions, end-stage organ failure, requiring transplantation, and posttraumatic stress disorder (PTSD). We report the views of a group of scientists who focus on the current state of scientific knowledge elucidating the mechanisms underlying the aforementioned disorders, novel therapeutic targets, and development of new approaches for clinical intervention. In conclusion, we dovetailed on four research areas of interest: 1) microbiome interaction with immune cells after hematopoietic cell and/or solid organ transplantation, graft-versus-host disease (GVHD) and graft rejection, 2) intestinal inflammation and its modification in IBD and cancer, 3) microbiome-neuron-immunity interplay in mental and physical health, and 4) microbiome-micronutrient-immune interactions during homeostasis and infectious diseases. At this VA field-based meeting, we proposed to explore a multi-disciplinary, multi-institutional, collaborative strategy to initiate a roadmap, specifically focusing on host microbiome-immune interactions among those with service-related chronic diseases to potentially identify novel and translatable therapeutic targets.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/19490976.2023.2267180
- OA Status
- gold
- Cited By
- 4
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387661003
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387661003Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/19490976.2023.2267180Digital Object Identifier
- Title
-
Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meetingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-16Full publication date if available
- Authors
-
Jun Sun, M. Nedim Ince, Clara Abraham, Terrence A. Barrett, Lisa A. Brenner, Yingzi Cong, Reza Dashti, Pradeep K. Dudeja, David E. Elliott, Thomas S. Griffith, Peter S. Heeger, Andrew J. Hoisington, Kaikobad Irani, Tae Kon Kim, Neeraj Kapur, Joseph R. Leventhal, Mansour Mohamadzadeh, Ece Mutlu, Rodney D. Newberry, Jonathan U. Peled, Israel Rubinstein, Salyka Sengsayadeth, Chen Sabrina Tan, Xiao‐Di Tan, Eric R. Tkaczyk, Jason A. Wertheim, Zheng Jenny ZhangList of authors in order
- Landing page
-
https://doi.org/10.1080/19490976.2023.2267180Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1080/19490976.2023.2267180Direct OA link when available
- Concepts
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Microbiome, Immunology, Immune system, Disease, Transplantation, Irritable bowel syndrome, Medicine, Inflammatory bowel disease, Immunosuppression, Population, Intensive care medicine, Bioinformatics, Biology, Psychiatry, Internal medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 4Per-year citation counts (last 5 years)
- References (count)
-
57Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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