Modulation of IKK/NF-κB Signaling: A Therapeutic Mechanism of Shilajit in Breast Cancer Cells Article Swipe
Zeinab Kordestani
,
Elham Melki
,
Reza Vahidi
,
Reza Shideh
,
N R Ghorbani
,
Seyede Elmeira Yazdi Rouholamini
,
Arezoo Saberi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.34172/jkmu.2024.12
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.34172/jkmu.2024.12
Background: Shilajit is a natural pale-brown to blackish-brown phytocomplex that exudes from mountain rocks in various parts of the world. In recent years, numerous pharmacological effects of shilajit have been explored through extensive experiments. Shilajit is known as an antioxidant and anti-inflammatory agent. Activation of the nuclear factor kappa B (NF-κB) signaling pathway could be an important player in inflammation-driven tumor progression. Therefore, the current study evaluated the anti-inflammatory effect of shilajit on a breast cancer cell line (MCF7). Methods: In this experimental study, the MCF7 cell line was treated with shilajit, and an MTT assay was applied to analyze the half-maximal inhibitory concentration (IC50) after 72 hours of treatment. Following this, the apoptotic rate was assessed using flow cytometry, and p50, RelB, and IKKα/β gene expression were evaluated using real-time PCR assay. Results: Shilajit had potent cytotoxic activity in a dose- and time-dependent manner with an IC50 of 280 μg/mL. Based on the Annexin-PI analysis, the IC50 concentration of this compound induced significant apoptosis in the cells, possibly through suppression of NF-κB (p50, RelB, and IKKα/β)-regulated genes. The real-time PCR results indicated that treating MCF7 cells at the IC50 dose of shilajit for 72 hours could reduce the mRNA expression levels of p50, RelB, and IKKα/β in the cells. Conclusion: The findings of the present experiment showed that shilajit may have promising anti-breast-tumor and anti-inflammatory activity through inhibition of the NF-κB signaling pathway. Therefore, shilajit can help treat breast cancer in combination with other standard treatments.
Related Topics
Concepts
RELB
Chemistry
Apoptosis
IκB kinase
NF-κB
MTT assay
Annexin
Pharmacology
IκBα
IC50
NFKB1
Cancer research
Biochemistry
Biology
In vitro
Transcription factor
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.34172/jkmu.2024.12
- https://jkmu.kmu.ac.ir/article_92278_2673bbd7f557c2861777b1522ff521f9.pdf
- OA Status
- diamond
- Cited By
- 1
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399541109
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399541109Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.34172/jkmu.2024.12Digital Object Identifier
- Title
-
Modulation of IKK/NF-κB Signaling: A Therapeutic Mechanism of Shilajit in Breast Cancer CellsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-29Full publication date if available
- Authors
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Zeinab Kordestani, Elham Melki, Reza Vahidi, Reza Shideh, N R Ghorbani, Seyede Elmeira Yazdi Rouholamini, Arezoo SaberiList of authors in order
- Landing page
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https://doi.org/10.34172/jkmu.2024.12Publisher landing page
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https://jkmu.kmu.ac.ir/article_92278_2673bbd7f557c2861777b1522ff521f9.pdfDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://jkmu.kmu.ac.ir/article_92278_2673bbd7f557c2861777b1522ff521f9.pdfDirect OA link when available
- Concepts
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RELB, Chemistry, Apoptosis, IκB kinase, NF-κB, MTT assay, Annexin, Pharmacology, IκBα, IC50, NFKB1, Cancer research, Biochemistry, Biology, In vitro, Transcription factor, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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