Modulation of OPC Mitochondrial Function by Inhibiting USP30 Promotes Their Differentiation
Article Swipe
Allison Soung
,
Roxanne V. Kyauk
,
Shristi Pandey
,
Yun‐An Shen
,
Mike Reichelt
,
Han Lin
,
Zhiyu Jiang
,
Praveen Kirshnamoorthy
,
Oded Foreman
,
Benjamin Lauffer
,
Tracy J. Yuen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/glia.24648
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/glia.24648
Multiple lines of evidence indicate that mitochondrial dysfunction occurs in demyelinating diseases, such as multiple sclerosis (MS). Failure of remyelination is thought to be caused in part by a block of oligodendrocyte progenitor cell (OPC) differentiation into oligodendrocytes, which generate myelin sheaths around axons. The process of OPC differentiation requires a substantial amount of energy and high demand for ATP which is supplied through the mitochondria. In this study, we highlight mitochondrial gene expression changes during OPC differentiation in two murine models of remyelination and in human postmortem MS brains. Given these transcriptional alterations, we then investigate whether genetic alteration of USP30, a mitochondrial deubiquitinase, enhances OPC differentiation and myelination. By genetic knockout of USP30, we observe increased OPC differentiation and myelination without affecting OPC proliferation and survival in in vitro and ex vivo assays. We also find that OPC differentiation is accelerated in vivo following focal demyelination in USP30 knockout mice. The promotion of OPC differentiation and myelination observed is associated with increased oxygen consumption rates in USP30 knockout OPCs. Together, these data indicate a role for mitochondrial function and USP30 in OPC differentiation and myelination.
Related Topics
Concepts
Remyelination
Biology
Cellular differentiation
Cell biology
Mitochondrion
Knockout mouse
Myelin
Oligodendrocyte
Progenitor cell
In vivo
Myelin basic protein
Stem cell
Neuroscience
Genetics
Gene
Central nervous system
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/glia.24648
- OA Status
- green
- Cited By
- 2
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404766434
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4404766434Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/glia.24648Digital Object Identifier
- Title
-
Modulation of
OPC Mitochondrial Function by InhibitingUSP30 Promotes Their DifferentiationWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-11-27Full publication date if available
- Authors
-
Allison Soung, Roxanne V. Kyauk, Shristi Pandey, Yun‐An Shen, Mike Reichelt, Han Lin, Zhiyu Jiang, Praveen Kirshnamoorthy, Oded Foreman, Benjamin Lauffer, Tracy J. YuenList of authors in order
- Landing page
-
https://doi.org/10.1002/glia.24648Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11845845Direct OA link when available
- Concepts
-
Remyelination, Biology, Cellular differentiation, Cell biology, Mitochondrion, Knockout mouse, Myelin, Oligodendrocyte, Progenitor cell, In vivo, Myelin basic protein, Stem cell, Neuroscience, Genetics, Gene, Central nervous systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
83Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4404766434 |
|---|---|
| doi | https://doi.org/10.1002/glia.24648 |
| ids.doi | https://doi.org/10.1002/glia.24648 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39601128 |
| ids.openalex | https://openalex.org/W4404766434 |
| fwci | 0.96049445 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D008928 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Mitochondria |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D018345 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Mice, Knockout |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D006801 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Humans |
| mesh[4].qualifier_ui | Q000502 |
| mesh[4].descriptor_ui | D002454 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | physiology |
| mesh[4].descriptor_name | Cell Differentiation |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D051379 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Mice |
| mesh[6].qualifier_ui | Q000473 |
| mesh[6].descriptor_ui | D009103 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | pathology |
| mesh[6].descriptor_name | Multiple Sclerosis |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D009103 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Multiple Sclerosis |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D008810 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Mice, Inbred C57BL |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D009836 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Oligodendroglia |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D013869 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Thiolester Hydrolases |
| mesh[11].qualifier_ui | Q000378 |
| mesh[11].descriptor_ui | D013869 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | metabolism |
| mesh[11].descriptor_name | Thiolester Hydrolases |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D009186 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Myelin Sheath |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D002478 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Cells, Cultured |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D024101 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Mitochondrial Proteins |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D024101 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Mitochondrial Proteins |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D000073637 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Oligodendrocyte Precursor Cells |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D008297 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Male |
| mesh[18].qualifier_ui | Q000473 |
| mesh[18].descriptor_ui | D003711 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | pathology |
| mesh[18].descriptor_name | Demyelinating Diseases |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D003711 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Demyelinating Diseases |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D005260 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Female |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000818 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Animals |
| mesh[22].qualifier_ui | Q000502 |
| mesh[22].descriptor_ui | D002454 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | physiology |
| mesh[22].descriptor_name | Cell Differentiation |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D008928 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Mitochondria |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D006801 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Humans |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D018345 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Mice, Knockout |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D000073637 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Oligodendrocyte Precursor Cells |
| mesh[27].qualifier_ui | Q000187 |
| mesh[27].descriptor_ui | D000073637 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | drug effects |
| mesh[27].descriptor_name | Oligodendrocyte Precursor Cells |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D051379 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Mice |
| mesh[29].qualifier_ui | Q000473 |
| mesh[29].descriptor_ui | D009103 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | pathology |
| mesh[29].descriptor_name | Multiple Sclerosis |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D009103 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Multiple Sclerosis |
| mesh[31].qualifier_ui | Q000235 |
| mesh[31].descriptor_ui | D009103 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | genetics |
| mesh[31].descriptor_name | Multiple Sclerosis |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D008810 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Mice, Inbred C57BL |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D009836 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Oligodendroglia |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D009186 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Myelin Sheath |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D002478 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Cells, Cultured |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D008297 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Male |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D005260 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Female |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D013869 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Thiolester Hydrolases |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D024101 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Mitochondrial Proteins |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D000818 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Animals |
| mesh[41].qualifier_ui | Q000502 |
| mesh[41].descriptor_ui | D002454 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | physiology |
| mesh[41].descriptor_name | Cell Differentiation |
| mesh[42].qualifier_ui | Q000378 |
| mesh[42].descriptor_ui | D008928 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | metabolism |
| mesh[42].descriptor_name | Mitochondria |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D006801 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Humans |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D018345 |
| mesh[44].is_major_topic | True |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Mice, Knockout |
| mesh[45].qualifier_ui | Q000378 |
| mesh[45].descriptor_ui | D000073637 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | metabolism |
| mesh[45].descriptor_name | Oligodendrocyte Precursor Cells |
| mesh[46].qualifier_ui | Q000187 |
| mesh[46].descriptor_ui | D000073637 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | drug effects |
| mesh[46].descriptor_name | Oligodendrocyte Precursor Cells |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D051379 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Mice |
| mesh[48].qualifier_ui | Q000473 |
| mesh[48].descriptor_ui | D009103 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | pathology |
| mesh[48].descriptor_name | Multiple Sclerosis |
| mesh[49].qualifier_ui | Q000378 |
| mesh[49].descriptor_ui | D009103 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | metabolism |
| mesh[49].descriptor_name | Multiple Sclerosis |
| type | article |
| title | Modulation of |
| biblio.issue | 4 |
| biblio.volume | 73 |
| biblio.last_page | 787 |
| biblio.first_page | 773 |
| topics[0].id | https://openalex.org/T10301 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9994999766349792 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Mitochondrial Function and Pathology |
| topics[1].id | https://openalex.org/T11266 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9990000128746033 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2808 |
| topics[1].subfield.display_name | Neurology |
| topics[1].display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| topics[2].id | https://openalex.org/T10608 |
| topics[2].field.id | https://openalex.org/fields/28 |
| topics[2].field.display_name | Neuroscience |
| topics[2].score | 0.9987000226974487 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2806 |
| topics[2].subfield.display_name | Developmental Neuroscience |
| topics[2].display_name | Neurogenesis and neuroplasticity mechanisms |
| funders[0].id | https://openalex.org/F4320332193 |
| funders[0].ror | https://ror.org/04gndp242 |
| funders[0].display_name | Genentech |
| is_xpac | False |
| apc_list.value | 4940 |
| apc_list.currency | USD |
| apc_list.value_usd | 4940 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2777619251 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8686586618423462 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q7312279 |
| concepts[0].display_name | Remyelination |
| concepts[1].id | https://openalex.org/C86803240 |
| concepts[1].level | 0 |
| concepts[1].score | 0.7037990093231201 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[1].display_name | Biology |
| concepts[2].id | https://openalex.org/C148738053 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6017811894416809 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q210861 |
| concepts[2].display_name | Cellular differentiation |
| concepts[3].id | https://openalex.org/C95444343 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5794234275817871 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[3].display_name | Cell biology |
| concepts[4].id | https://openalex.org/C28859421 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5704318284988403 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q39572 |
| concepts[4].display_name | Mitochondrion |
| concepts[5].id | https://openalex.org/C182704531 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5667775869369507 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q1364740 |
| concepts[5].display_name | Knockout mouse |
| concepts[6].id | https://openalex.org/C2778609137 |
| concepts[6].level | 3 |
| concepts[6].score | 0.532826840877533 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q105790271 |
| concepts[6].display_name | Myelin |
| concepts[7].id | https://openalex.org/C2776985911 |
| concepts[7].level | 4 |
| concepts[7].score | 0.5011181831359863 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q916698 |
| concepts[7].display_name | Oligodendrocyte |
| concepts[8].id | https://openalex.org/C201750760 |
| concepts[8].level | 3 |
| concepts[8].score | 0.4464277923107147 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1896218 |
| concepts[8].display_name | Progenitor cell |
| concepts[9].id | https://openalex.org/C207001950 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4364128112792969 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q141124 |
| concepts[9].display_name | In vivo |
| concepts[10].id | https://openalex.org/C2780876595 |
| concepts[10].level | 4 |
| concepts[10].score | 0.4346710443496704 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q410974 |
| concepts[10].display_name | Myelin basic protein |
| concepts[11].id | https://openalex.org/C28328180 |
| concepts[11].level | 2 |
| concepts[11].score | 0.33308112621307373 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q48196 |
| concepts[11].display_name | Stem cell |
| concepts[12].id | https://openalex.org/C169760540 |
| concepts[12].level | 1 |
| concepts[12].score | 0.2841339111328125 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[12].display_name | Neuroscience |
| concepts[13].id | https://openalex.org/C54355233 |
| concepts[13].level | 1 |
| concepts[13].score | 0.1620211899280548 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[13].display_name | Genetics |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.15052592754364014 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| concepts[15].id | https://openalex.org/C529278444 |
| concepts[15].level | 2 |
| concepts[15].score | 0.14715808629989624 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q47273 |
| concepts[15].display_name | Central nervous system |
| keywords[0].id | https://openalex.org/keywords/remyelination |
| keywords[0].score | 0.8686586618423462 |
| keywords[0].display_name | Remyelination |
| keywords[1].id | https://openalex.org/keywords/biology |
| keywords[1].score | 0.7037990093231201 |
| keywords[1].display_name | Biology |
| keywords[2].id | https://openalex.org/keywords/cellular-differentiation |
| keywords[2].score | 0.6017811894416809 |
| keywords[2].display_name | Cellular differentiation |
| keywords[3].id | https://openalex.org/keywords/cell-biology |
| keywords[3].score | 0.5794234275817871 |
| keywords[3].display_name | Cell biology |
| keywords[4].id | https://openalex.org/keywords/mitochondrion |
| keywords[4].score | 0.5704318284988403 |
| keywords[4].display_name | Mitochondrion |
| keywords[5].id | https://openalex.org/keywords/knockout-mouse |
| keywords[5].score | 0.5667775869369507 |
| keywords[5].display_name | Knockout mouse |
| keywords[6].id | https://openalex.org/keywords/myelin |
| keywords[6].score | 0.532826840877533 |
| keywords[6].display_name | Myelin |
| keywords[7].id | https://openalex.org/keywords/oligodendrocyte |
| keywords[7].score | 0.5011181831359863 |
| keywords[7].display_name | Oligodendrocyte |
| keywords[8].id | https://openalex.org/keywords/progenitor-cell |
| keywords[8].score | 0.4464277923107147 |
| keywords[8].display_name | Progenitor cell |
| keywords[9].id | https://openalex.org/keywords/in-vivo |
| keywords[9].score | 0.4364128112792969 |
| keywords[9].display_name | In vivo |
| keywords[10].id | https://openalex.org/keywords/myelin-basic-protein |
| keywords[10].score | 0.4346710443496704 |
| keywords[10].display_name | Myelin basic protein |
| keywords[11].id | https://openalex.org/keywords/stem-cell |
| keywords[11].score | 0.33308112621307373 |
| keywords[11].display_name | Stem cell |
| keywords[12].id | https://openalex.org/keywords/neuroscience |
| keywords[12].score | 0.2841339111328125 |
| keywords[12].display_name | Neuroscience |
| keywords[13].id | https://openalex.org/keywords/genetics |
| keywords[13].score | 0.1620211899280548 |
| keywords[13].display_name | Genetics |
| keywords[14].id | https://openalex.org/keywords/gene |
| keywords[14].score | 0.15052592754364014 |
| keywords[14].display_name | Gene |
| keywords[15].id | https://openalex.org/keywords/central-nervous-system |
| keywords[15].score | 0.14715808629989624 |
| keywords[15].display_name | Central nervous system |
| language | en |
| locations[0].id | doi:10.1002/glia.24648 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S147407642 |
| locations[0].source.issn | 0894-1491, 1098-1136 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0894-1491 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Glia |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Glia |
| locations[0].landing_page_url | https://doi.org/10.1002/glia.24648 |
| locations[1].id | pmid:39601128 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Glia |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39601128 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11845845 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Glia |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11845845 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5082790244 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1590-6038 |
| authorships[0].author.display_name | Allison Soung |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Allison L. Soung |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[1].author.id | https://openalex.org/A5049134262 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Roxanne V. Kyauk |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Roxanne V. Kyauk |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[2].author.id | https://openalex.org/A5011771406 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-0954-6734 |
| authorships[2].author.display_name | Shristi Pandey |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Bioinformatics and Computational Biology Genentech Inc South San Francisco California USA |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Shristi Pandey |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Bioinformatics and Computational Biology Genentech Inc South San Francisco California USA |
| authorships[3].author.id | https://openalex.org/A5113172682 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Yun‐An Shen |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Yun‐An A. Shen |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[4].author.id | https://openalex.org/A5050078182 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Mike Reichelt |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pathology Genentech Inc South San Francisco California USA |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Mike Reichelt |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Pathology Genentech Inc South San Francisco California USA |
| authorships[5].author.id | https://openalex.org/A5019096232 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-5641-2117 |
| authorships[5].author.display_name | Han Lin |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Han Lin |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[6].author.id | https://openalex.org/A5014401391 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-6360-8262 |
| authorships[6].author.display_name | Zhiyu Jiang |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Zhiyu Jiang |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[7].author.id | https://openalex.org/A5114824756 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Praveen Kirshnamoorthy |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Pathology Genentech Inc South San Francisco California USA |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Praveen Kirshnamoorthy |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Pathology Genentech Inc South San Francisco California USA |
| authorships[8].author.id | https://openalex.org/A5073095750 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-8197-3186 |
| authorships[8].author.display_name | Oded Foreman |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Pathology Genentech Inc South San Francisco California USA |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Oded Foreman |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Pathology Genentech Inc South San Francisco California USA |
| authorships[9].author.id | https://openalex.org/A5009109792 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Benjamin Lauffer |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Benjamin E. Lauffer |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[10].author.id | https://openalex.org/A5071965611 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-3451-9279 |
| authorships[10].author.display_name | Tracy J. Yuen |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Neuroscience Genentech Inc South San Francisco California USA |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Tracy J. Yuen |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Neuroscience Genentech Inc South San Francisco California USA |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11845845 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2024-11-28T00:00:00 |
| display_name | Modulation of |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10301 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9994999766349792 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Mitochondrial Function and Pathology |
| related_works | https://openalex.org/W4280544143, https://openalex.org/W2131781728, https://openalex.org/W2944147248, https://openalex.org/W1966630100, https://openalex.org/W4283582725, https://openalex.org/W2160412284, https://openalex.org/W1509596990, https://openalex.org/W1973028948, https://openalex.org/W4243460554, https://openalex.org/W2161775276 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:11845845 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | other-oa |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | https://openalex.org/licenses/other-oa |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Glia |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11845845 |
| primary_location.id | doi:10.1002/glia.24648 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S147407642 |
| primary_location.source.issn | 0894-1491, 1098-1136 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0894-1491 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Glia |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Glia |
| primary_location.landing_page_url | https://doi.org/10.1002/glia.24648 |
| publication_date | 2024-11-27 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2775627975, https://openalex.org/W2054239073, https://openalex.org/W2049016912, https://openalex.org/W2159729185, https://openalex.org/W2136251247, https://openalex.org/W2005950079, https://openalex.org/W2168122373, https://openalex.org/W2058065156, https://openalex.org/W2511725062, https://openalex.org/W2142922236, https://openalex.org/W2754278602, https://openalex.org/W2056928450, https://openalex.org/W2337852945, https://openalex.org/W2943993219, https://openalex.org/W2902902889, https://openalex.org/W2169256396, https://openalex.org/W3093239695, https://openalex.org/W1963577160, https://openalex.org/W2500427481, https://openalex.org/W1877873625, https://openalex.org/W2170487295, https://openalex.org/W2062326815, https://openalex.org/W2997716926, https://openalex.org/W2127546245, https://openalex.org/W3206731434, https://openalex.org/W2138747394, https://openalex.org/W2149715738, https://openalex.org/W2149515432, https://openalex.org/W2118855202, https://openalex.org/W2807910244, https://openalex.org/W2920688947, https://openalex.org/W1964416005, https://openalex.org/W1983832155, https://openalex.org/W2141459724, https://openalex.org/W2979042352, https://openalex.org/W2082307109, https://openalex.org/W4292755801, https://openalex.org/W2120683729, https://openalex.org/W2114080032, https://openalex.org/W3009651870, https://openalex.org/W2168013509, https://openalex.org/W3106539179, https://openalex.org/W2276987527, https://openalex.org/W2888671646, https://openalex.org/W3042070552, https://openalex.org/W1974365396, https://openalex.org/W3133943826, https://openalex.org/W3035591587, https://openalex.org/W2168546891, https://openalex.org/W3217207941, https://openalex.org/W2165349828, https://openalex.org/W2011124366, https://openalex.org/W4315435458, https://openalex.org/W2038976751, https://openalex.org/W2089851064, https://openalex.org/W2063659485, https://openalex.org/W2145794514, https://openalex.org/W2124940469, https://openalex.org/W2054275187, https://openalex.org/W4283712086, https://openalex.org/W2951560273, https://openalex.org/W4378909224, https://openalex.org/W3197136220, https://openalex.org/W2100904149, https://openalex.org/W4388638467, https://openalex.org/W3119486354, https://openalex.org/W3092603594, https://openalex.org/W3024605887, https://openalex.org/W3101192230, https://openalex.org/W2094044389, https://openalex.org/W3019747475, https://openalex.org/W2980489405, https://openalex.org/W3123872097, https://openalex.org/W2911725378, https://openalex.org/W2913848851, https://openalex.org/W1984891852, https://openalex.org/W2056561094, https://openalex.org/W2916840880, https://openalex.org/W2995766518, https://openalex.org/W2005578607, https://openalex.org/W2012841879, https://openalex.org/W2570411016, https://openalex.org/W2147062889 |
| referenced_works_count | 83 |
| abstract_inverted_index.a | 29, 51, 103, 176 |
| abstract_inverted_index.By | 111 |
| abstract_inverted_index.In | 67 |
| abstract_inverted_index.MS | 89 |
| abstract_inverted_index.We | 136 |
| abstract_inverted_index.as | 14 |
| abstract_inverted_index.be | 24 |
| abstract_inverted_index.by | 28 |
| abstract_inverted_index.ex | 133 |
| abstract_inverted_index.in | 10, 26, 79, 86, 129, 130, 144, 149, 168, 183 |
| abstract_inverted_index.is | 21, 62, 142, 161 |
| abstract_inverted_index.of | 3, 19, 31, 47, 54, 83, 101, 114, 155 |
| abstract_inverted_index.to | 23 |
| abstract_inverted_index.we | 70, 95, 116 |
| abstract_inverted_index.ATP | 60 |
| abstract_inverted_index.OPC | 48, 77, 107, 119, 125, 140, 156, 184 |
| abstract_inverted_index.The | 45, 153 |
| abstract_inverted_index.and | 56, 85, 109, 121, 127, 132, 158, 181, 186 |
| abstract_inverted_index.for | 59, 178 |
| abstract_inverted_index.the | 65 |
| abstract_inverted_index.two | 80 |
| abstract_inverted_index.also | 137 |
| abstract_inverted_index.cell | 34 |
| abstract_inverted_index.data | 174 |
| abstract_inverted_index.find | 138 |
| abstract_inverted_index.gene | 73 |
| abstract_inverted_index.high | 57 |
| abstract_inverted_index.into | 37 |
| abstract_inverted_index.part | 27 |
| abstract_inverted_index.role | 177 |
| abstract_inverted_index.such | 13 |
| abstract_inverted_index.that | 6, 139 |
| abstract_inverted_index.then | 96 |
| abstract_inverted_index.this | 68 |
| abstract_inverted_index.vivo | 134, 145 |
| abstract_inverted_index.with | 163 |
| abstract_inverted_index.(MS). | 17 |
| abstract_inverted_index.(OPC) | 35 |
| abstract_inverted_index.Given | 91 |
| abstract_inverted_index.OPCs. | 171 |
| abstract_inverted_index.USP30 | 150, 169, 182 |
| abstract_inverted_index.block | 30 |
| abstract_inverted_index.focal | 147 |
| abstract_inverted_index.human | 87 |
| abstract_inverted_index.lines | 2 |
| abstract_inverted_index.mice. | 152 |
| abstract_inverted_index.rates | 167 |
| abstract_inverted_index.these | 92, 173 |
| abstract_inverted_index.vitro | 131 |
| abstract_inverted_index.which | 39, 61 |
| abstract_inverted_index.USP30, | 102, 115 |
| abstract_inverted_index.amount | 53 |
| abstract_inverted_index.around | 43 |
| abstract_inverted_index.axons. | 44 |
| abstract_inverted_index.caused | 25 |
| abstract_inverted_index.demand | 58 |
| abstract_inverted_index.during | 76 |
| abstract_inverted_index.energy | 55 |
| abstract_inverted_index.models | 82 |
| abstract_inverted_index.murine | 81 |
| abstract_inverted_index.myelin | 41 |
| abstract_inverted_index.occurs | 9 |
| abstract_inverted_index.oxygen | 165 |
| abstract_inverted_index.study, | 69 |
| abstract_inverted_index.Failure | 18 |
| abstract_inverted_index.assays. | 135 |
| abstract_inverted_index.brains. | 90 |
| abstract_inverted_index.changes | 75 |
| abstract_inverted_index.genetic | 99, 112 |
| abstract_inverted_index.observe | 117 |
| abstract_inverted_index.process | 46 |
| abstract_inverted_index.sheaths | 42 |
| abstract_inverted_index.thought | 22 |
| abstract_inverted_index.through | 64 |
| abstract_inverted_index.whether | 98 |
| abstract_inverted_index.without | 123 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Multiple | 1 |
| abstract_inverted_index.enhances | 106 |
| abstract_inverted_index.evidence | 4 |
| abstract_inverted_index.function | 180 |
| abstract_inverted_index.generate | 40 |
| abstract_inverted_index.indicate | 5, 175 |
| abstract_inverted_index.knockout | 113, 151, 170 |
| abstract_inverted_index.multiple | 15 |
| abstract_inverted_index.observed | 160 |
| abstract_inverted_index.requires | 50 |
| abstract_inverted_index.supplied | 63 |
| abstract_inverted_index.survival | 128 |
| abstract_inverted_index.Together, | 172 |
| abstract_inverted_index.affecting | 124 |
| abstract_inverted_index.diseases, | 12 |
| abstract_inverted_index.following | 146 |
| abstract_inverted_index.highlight | 71 |
| abstract_inverted_index.increased | 118, 164 |
| abstract_inverted_index.promotion | 154 |
| abstract_inverted_index.sclerosis | 16 |
| abstract_inverted_index.alteration | 100 |
| abstract_inverted_index.associated | 162 |
| abstract_inverted_index.expression | 74 |
| abstract_inverted_index.postmortem | 88 |
| abstract_inverted_index.progenitor | 33 |
| abstract_inverted_index.accelerated | 143 |
| abstract_inverted_index.consumption | 166 |
| abstract_inverted_index.dysfunction | 8 |
| abstract_inverted_index.investigate | 97 |
| abstract_inverted_index.myelination | 122, 159 |
| abstract_inverted_index.substantial | 52 |
| abstract_inverted_index.alterations, | 94 |
| abstract_inverted_index.myelination. | 110, 187 |
| abstract_inverted_index.demyelinating | 11 |
| abstract_inverted_index.demyelination | 148 |
| abstract_inverted_index.mitochondria. | 66 |
| abstract_inverted_index.mitochondrial | 7, 72, 104, 179 |
| abstract_inverted_index.proliferation | 126 |
| abstract_inverted_index.remyelination | 20, 84 |
| abstract_inverted_index.deubiquitinase, | 105 |
| abstract_inverted_index.differentiation | 36, 49, 78, 108, 120, 141, 157, 185 |
| abstract_inverted_index.oligodendrocyte | 32 |
| abstract_inverted_index.transcriptional | 93 |
| abstract_inverted_index.oligodendrocytes, | 38 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 11 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/7 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Affordable and clean energy |
| citation_normalized_percentile.value | 0.7156677 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |