Molecular and organizational diversity intersect to generate functional synaptic heterogeneity within and between excitatory neuronal subtypes Article Swipe
Audrey T. Medeiros
,
Scott J. Gratz
,
A. Delgado
,
Jason T. Ritt
,
Kate M. O’Connor-Giles
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.88412.1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.88412.1
Synaptic heterogeneity is a hallmark of complex nervous systems that enables reliable and responsive communication in neural circuits. In this study, we investigated the contributions of voltage-gated calcium channels (VGCCs) to synaptic heterogeneity at two closely related Drosophila glutamatergic motor neurons, one low-and one high-Pr. We find that VGCC levels are highly predictive of heterogeneous release probability among individual active zones (AZs) of low-or high-Pr inputs, but not between neuronal subtypes. Underlying organizational differences in the AZ cytomatrix, VGCC composition, and a more compact arrangement of VGCCs alter the relationship between VGCC levels and Pr at AZs of low-vs. high-Pr inputs, explaining this apparent paradox. We further find that the CAST/ELKS AZ scaffolding protein Bruchpilot differentially regulates VGCC levels at low-and high-Pr AZs following acute glutamate receptor inhibition, indicating that synapse-specific organization also impacts adaptive plasticity. These findings reveal intersecting levels of molecular and spatial diversity with context-specific effects on heterogeneity in synaptic strength and plasticity.
Related Topics
Concepts
Neuroscience
Synaptic plasticity
Excitatory postsynaptic potential
Glutamate receptor
Context (archaeology)
Glutamatergic
Metaplasticity
Biology
Synapse
Nonsynaptic plasticity
Receptor
Genetics
Inhibitory postsynaptic potential
Paleontology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.88412.1
- OA Status
- gold
- Cited By
- 5
- References
- 92
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4384560875
All OpenAlex metadata
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https://openalex.org/W4384560875Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.88412.1Digital Object Identifier
- Title
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Molecular and organizational diversity intersect to generate functional synaptic heterogeneity within and between excitatory neuronal subtypesWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-07-17Full publication date if available
- Authors
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Audrey T. Medeiros, Scott J. Gratz, A. Delgado, Jason T. Ritt, Kate M. O’Connor-GilesList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.88412.1Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7554/elife.88412.1Direct OA link when available
- Concepts
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Neuroscience, Synaptic plasticity, Excitatory postsynaptic potential, Glutamate receptor, Context (archaeology), Glutamatergic, Metaplasticity, Biology, Synapse, Nonsynaptic plasticity, Receptor, Genetics, Inhibitory postsynaptic potential, PaleontologyTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 2, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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92Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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