Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs Article Swipe
Belgin Dogan
,
Shiying Zhang
,
Sara E. Kalla
,
Esra I. Dogan
,
Cindy Guo
,
Chelston Ang
,
Kenneth W. Simpson
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics9090540
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics9090540
Invasive Escherichia coli is causally associated with granulomatous colitis (GC) of Boxer dogs and French Bulldogs. The virulence determinants of GC E. coli are unclear. E. coli isolated from 16 GC (36 strains) and 17 healthy control (HC: 33 strains) dogs were diverse in phylogeny, genotype, and serotype and lacked diarrheagenic genes. Genes encoding type II (gsp), IV (traC), and VI (hcp) secretion systems, long polar fimbriae (lpfA154/141), and iron acquisition (fyuA, chuA) were frequent in GC and HC. E. coli from 14/15 GC and 10/11 HC invaded Caco-2 better than non-pathogenic E. coli strain DH5α, with invasion correlated with motility and presence of chuA and colV. E. coli from all GC and 10/11 HC survived better than DH5α in J774 macrophages, with adherent-invasive E. coli (AIEC) in 60% GC and 73% HC. AIEC replicated in monocyte derived macrophages from a GC Boxer with CD48/SLAM risk haplotype but not the HC. Fluroquinolone resistant E. coli were less motile and invasive than fluoroquinolone sensitive (p < 0.05), and only 1/8 resistant strains met criteria for AIEC. In conclusion GC E. coli are diverse, resemble extraintestinal pathogenic E. coli (ExPEC), including AIEC, and can replicate in GC-susceptible macrophages. They are likely resident pathosymbionts that can opportunistically persist within macrophages of a GC-susceptible dog.
Related Topics
Concepts
Escherichia coli
Biology
Microbiology
Virulence
Fimbria
Pathogenic Escherichia coli
Serotype
Bacteria
Phenotype
Genotype
Ileum
Enterobacteriaceae
Colitis
Gene
Genetics
Immunology
Endocrinology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antibiotics9090540
- https://www.mdpi.com/2079-6382/9/9/540/pdf
- OA Status
- gold
- Cited By
- 23
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3080592705
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3080592705Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/antibiotics9090540Digital Object Identifier
- Title
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Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer DogsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-08-25Full publication date if available
- Authors
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Belgin Dogan, Shiying Zhang, Sara E. Kalla, Esra I. Dogan, Cindy Guo, Chelston Ang, Kenneth W. SimpsonList of authors in order
- Landing page
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https://doi.org/10.3390/antibiotics9090540Publisher landing page
- PDF URL
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https://www.mdpi.com/2079-6382/9/9/540/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2079-6382/9/9/540/pdfDirect OA link when available
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Escherichia coli, Biology, Microbiology, Virulence, Fimbria, Pathogenic Escherichia coli, Serotype, Bacteria, Phenotype, Genotype, Ileum, Enterobacteriaceae, Colitis, Gene, Genetics, Immunology, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
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23Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 2, 2023: 7, 2022: 2, 2021: 6Per-year citation counts (last 5 years)
- References (count)
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67Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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