Molecular Characterization of HOXA2 and HOXA3 Binding Properties Article Swipe
Joshua Mallen
,
Manisha Kalsan
,
Peyman Zarrineh
,
Laure Bridoux
,
Shandar Ahmad
,
Nicoletta Bobola
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jdb9040055
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/jdb9040055
The highly conserved HOX homeodomain (HD) transcription factors (TFs) establish the identity of different body parts along the antero–posterior axis of bilaterian animals. Segment diversification and the morphogenesis of different structures is achieved by generating precise patterns of HOX expression along the antero–posterior axis and by the ability of different HOX TFs to instruct unique and specific transcriptional programs. However, HOX binding properties in vitro, characterised by the recognition of similar AT-rich binding sequences, do not account for the ability of different HOX to instruct segment-specific transcriptional programs. To address this problem, we previously compared HOXA2 and HOXA3 binding in vivo. Here, we explore if sequence motif enrichments observed in vivo are explained by binding affinities in vitro. Unexpectedly, we found that the highest enriched motif in HOXA2 peaks was not recognised by HOXA2 in vitro, highlighting the importance of investigating HOX binding in its physiological context. We also report the ability of HOXA2 and HOXA3 to heterodimerise, which may have functional consequences for the HOX patterning function in vivo.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jdb9040055
- https://www.mdpi.com/2221-3759/9/4/55/pdf?version=1638531221
- OA Status
- gold
- Cited By
- 3
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200257091
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Raw OpenAlex JSON
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https://openalex.org/W4200257091Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jdb9040055Digital Object Identifier
- Title
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Molecular Characterization of HOXA2 and HOXA3 Binding PropertiesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-12-03Full publication date if available
- Authors
-
Joshua Mallen, Manisha Kalsan, Peyman Zarrineh, Laure Bridoux, Shandar Ahmad, Nicoletta BobolaList of authors in order
- Landing page
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https://doi.org/10.3390/jdb9040055Publisher landing page
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https://www.mdpi.com/2221-3759/9/4/55/pdf?version=1638531221Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2221-3759/9/4/55/pdf?version=1638531221Direct OA link when available
- Concepts
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Hox gene, Homeobox, Transcription factor, Biology, Genetics, Binding site, Cell biology, Motif (music), Gene, Computational biology, Physics, AcousticsTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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