Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer Article Swipe
Peter Dietrich
,
Laura Wormser
,
Valerie Fritz
,
Tatjana Seitz
,
Monica De Maria
,
Alexandra Schambony
,
Andreas E. Kremer
,
Claudia Günther
,
Timo Itzel
,
Wolfgang E. Thasler
,
Andreas Teufel
,
Jonel Trebicka
,
Arndt Hartmann
,
Markus F. Neurath
,
Stephan von Hörsten
,
Anja‐Katrin Bosserhoff
,
Claus Hellerbrand
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1172/jci131919
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1172/jci131919
Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest cancer types worldwide. As a result of globally increasing risk factors including metabolic disorders, the incidence rates of HCC are still rising. However, the molecular hallmarks of HCC remain poorly understood. Neuropeptide Y (NPY) and NPY receptors represent a highly conserved, stress-activated system involved in diverse cancer-related hallmarks including aging and metabolic alterations, but its impact on liver cancer had been unclear. Here, we observed increased expression of NPY5 receptor (Y5R) in HCC, which correlated with tumor growth and survival. Furthermore, we found that its ligand NPY was secreted by peritumorous hepatocytes. Hepatocyte-derived NPY promoted HCC progression by Y5R activation. TGF-β1 was identified as a regulator of NPY in hepatocytes and induced Y5R in invasive cancer cells. Moreover, NPY conversion by dipeptidylpeptidase 4 (DPP4) augmented Y5R activation and function in liver cancer. The TGF-β/NPY/Y5R axis and DPP4 represent attractive therapeutic targets for controlling liver cancer progression.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1172/jci131919
- http://www.jci.org/articles/view/131919/files/pdf
- OA Status
- bronze
- Cited By
- 42
- References
- 97
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3003235320
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3003235320Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1172/jci131919Digital Object Identifier
- Title
-
Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancerWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-30Full publication date if available
- Authors
-
Peter Dietrich, Laura Wormser, Valerie Fritz, Tatjana Seitz, Monica De Maria, Alexandra Schambony, Andreas E. Kremer, Claudia Günther, Timo Itzel, Wolfgang E. Thasler, Andreas Teufel, Jonel Trebicka, Arndt Hartmann, Markus F. Neurath, Stephan von Hörsten, Anja‐Katrin Bosserhoff, Claus HellerbrandList of authors in order
- Landing page
-
https://doi.org/10.1172/jci131919Publisher landing page
- PDF URL
-
https://www.jci.org/articles/view/131919/files/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.jci.org/articles/view/131919/files/pdfDirect OA link when available
- Concepts
-
Neuropeptide Y receptor, Biology, Liver cancer, Cancer research, Hepatocellular carcinoma, Cancer, Receptor, Tumor microenvironment, Crosstalk, Internal medicine, Endocrinology, Medicine, Neuropeptide, Genetics, Optics, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
42Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 3, 2023: 7, 2022: 11, 2021: 9Per-year citation counts (last 5 years)
- References (count)
-
97Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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