Molecular Dynamic Analysis of Carbapenem-Resistant Klebsiella pneumonia’s Porin Proteins with Beta Lactam Antibiotics and Zinc Oxide Nanoparticles Article Swipe
Rasha Elsayim
,
Abeer S. Aloufi
,
Yosra Modafer
,
Wafa Ali Eltayb
,
Alaa Alnoor Alameen
,
Samah Awad Abdurahim
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/molecules28062510
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/molecules28062510
To prevent the rapidly increasing prevalence of bacterial resistance, it is crucial to discover new antibacterial agents. The emergence of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae has been associated with a higher mortality rate in gulf union countries and worldwide. Compared to physical and chemical approaches, green zinc oxide nanoparticle (ZnO-NP) synthesis is thought to be significantly safer and more ecofriendly. The present study used molecular dynamics (MD) to examine how ZnO-NPs interact with porin protein (GLO21), a target of β-lactam antibiotics, and then tested this interaction in vitro by determining the zone of inhibition (IZ), minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC), as well as the alteration of KPC’s cell surface. The nanoparticles produced were characterized by UV-Vis spectroscopy, zetasizer, Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). In silico investigation was conducted using a variety of computational techniques, including Autodock Vina for protein and ligand docking and Desmond for MD simulation. The candidate ligands that interact with the GLO21 protein were biosynthesized ZnO-NPs, meropenem, imipenem, and cefepime. Analysis of MD revealed that the ZnO-NPs had the highest log P value (−9.1 kcal/mol), which indicates higher permeability through the bacterial surface, followed by cefepime (−7.9 kcal/mol), meropenem (−7.5 kcal/mol), and imipenem (−6.4 kcal/mol). All tested compounds and ZnO-NPs possess similar binding sites of porin proteins. An MD simulation study showed a stable system for ZnO-NPs and cefepime, as confirmed by RMSD and RMSF values during 100 ns trajectories. The test compounds were further inspected for their intersection with porin in terms of hydrophobic, hydrogen, and ionic levels. In addition, the stability of these bonds were measured by observing the protein–ligand contact within 100 ns trajectories. ZnO-NPs showed promising results for fighting KPC, represented in MIC (0.2 mg/mL), MBC (0.5 mg/mL), and ZI (24 mm diameter). To draw the conclusion that ZnO-NP is a potent antibacterial agent and in order to identify potent antibacterial drugs that do not harm human cells, further in vivo studies are required.
Related Topics
Concepts
Cefepime
Meropenem
Imipenem
Porin
Chemistry
Broth microdilution
Klebsiella pneumoniae
Zinc
Klebsiella pneumonia
Nuclear chemistry
Docking (animal)
Minimum inhibitory concentration
Microbiology
Biochemistry
Biology
Antibiotic resistance
Antibiotics
Organic chemistry
Bacterial outer membrane
Escherichia coli
Medicine
Nursing
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules28062510
- https://www.mdpi.com/1420-3049/28/6/2510/pdf?version=1678438819
- OA Status
- gold
- Cited By
- 4
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4323854054
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4323854054Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/molecules28062510Digital Object Identifier
- Title
-
Molecular Dynamic Analysis of Carbapenem-Resistant Klebsiella pneumonia’s Porin Proteins with Beta Lactam Antibiotics and Zinc Oxide NanoparticlesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-09Full publication date if available
- Authors
-
Rasha Elsayim, Abeer S. Aloufi, Yosra Modafer, Wafa Ali Eltayb, Alaa Alnoor Alameen, Samah Awad AbdurahimList of authors in order
- Landing page
-
https://doi.org/10.3390/molecules28062510Publisher landing page
- PDF URL
-
https://www.mdpi.com/1420-3049/28/6/2510/pdf?version=1678438819Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1420-3049/28/6/2510/pdf?version=1678438819Direct OA link when available
- Concepts
-
Cefepime, Meropenem, Imipenem, Porin, Chemistry, Broth microdilution, Klebsiella pneumoniae, Zinc, Klebsiella pneumonia, Nuclear chemistry, Docking (animal), Minimum inhibitory concentration, Microbiology, Biochemistry, Biology, Antibiotic resistance, Antibiotics, Organic chemistry, Bacterial outer membrane, Escherichia coli, Medicine, Nursing, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
39Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4323854054 |
|---|---|
| doi | https://doi.org/10.3390/molecules28062510 |
| ids.doi | https://doi.org/10.3390/molecules28062510 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36985482 |
| ids.openalex | https://openalex.org/W4323854054 |
| fwci | 0.64268886 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000737 |
| mesh[1].descriptor_ui | D015034 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | chemistry |
| mesh[1].descriptor_name | Zinc Oxide |
| mesh[2].qualifier_ui | Q000494 |
| mesh[2].descriptor_ui | D015780 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | pharmacology |
| mesh[2].descriptor_name | Carbapenems |
| mesh[3].qualifier_ui | Q000494 |
| mesh[3].descriptor_ui | D000077731 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | pharmacology |
| mesh[3].descriptor_name | Meropenem |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D007709 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Klebsiella |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D000077723 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Cefepime |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D018272 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Porins |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D056004 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Molecular Dynamics Simulation |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D008024 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Ligands |
| mesh[9].qualifier_ui | Q000494 |
| mesh[9].descriptor_ui | D000900 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | pharmacology |
| mesh[9].descriptor_name | Anti-Bacterial Agents |
| mesh[10].qualifier_ui | Q000737 |
| mesh[10].descriptor_ui | D000900 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | chemistry |
| mesh[10].descriptor_name | Anti-Bacterial Agents |
| mesh[11].qualifier_ui | Q000737 |
| mesh[11].descriptor_ui | D053758 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | chemistry |
| mesh[11].descriptor_name | Nanoparticles |
| mesh[12].qualifier_ui | Q000494 |
| mesh[12].descriptor_ui | D015378 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | pharmacology |
| mesh[12].descriptor_name | Imipenem |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D008997 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Monobactams |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D008826 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Microbial Sensitivity Tests |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D007711 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Klebsiella pneumoniae |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D011014 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Pneumonia |
| mesh[17].qualifier_ui | Q000737 |
| mesh[17].descriptor_ui | D053768 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | chemistry |
| mesh[17].descriptor_name | Metal Nanoparticles |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D017550 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Spectroscopy, Fourier Transform Infrared |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D006801 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Humans |
| mesh[20].qualifier_ui | Q000737 |
| mesh[20].descriptor_ui | D015034 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | chemistry |
| mesh[20].descriptor_name | Zinc Oxide |
| mesh[21].qualifier_ui | Q000494 |
| mesh[21].descriptor_ui | D015780 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | pharmacology |
| mesh[21].descriptor_name | Carbapenems |
| mesh[22].qualifier_ui | Q000494 |
| mesh[22].descriptor_ui | D000077731 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | pharmacology |
| mesh[22].descriptor_name | Meropenem |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D007709 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Klebsiella |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D000077723 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Cefepime |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D018272 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Porins |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D056004 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Molecular Dynamics Simulation |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D008024 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Ligands |
| mesh[28].qualifier_ui | Q000494 |
| mesh[28].descriptor_ui | D000900 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | pharmacology |
| mesh[28].descriptor_name | Anti-Bacterial Agents |
| mesh[29].qualifier_ui | Q000737 |
| mesh[29].descriptor_ui | D000900 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | chemistry |
| mesh[29].descriptor_name | Anti-Bacterial Agents |
| mesh[30].qualifier_ui | Q000737 |
| mesh[30].descriptor_ui | D053758 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | chemistry |
| mesh[30].descriptor_name | Nanoparticles |
| mesh[31].qualifier_ui | Q000494 |
| mesh[31].descriptor_ui | D015378 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | pharmacology |
| mesh[31].descriptor_name | Imipenem |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D008997 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Monobactams |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D008826 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Microbial Sensitivity Tests |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D007711 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Klebsiella pneumoniae |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D011014 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Pneumonia |
| mesh[36].qualifier_ui | Q000737 |
| mesh[36].descriptor_ui | D053768 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | chemistry |
| mesh[36].descriptor_name | Metal Nanoparticles |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D017550 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Spectroscopy, Fourier Transform Infrared |
| type | article |
| title | Molecular Dynamic Analysis of Carbapenem-Resistant Klebsiella pneumonia’s Porin Proteins with Beta Lactam Antibiotics and Zinc Oxide Nanoparticles |
| biblio.issue | 6 |
| biblio.volume | 28 |
| biblio.last_page | 2510 |
| biblio.first_page | 2510 |
| topics[0].id | https://openalex.org/T10147 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1313 |
| topics[0].subfield.display_name | Molecular Medicine |
| topics[0].display_name | Antibiotic Resistance in Bacteria |
| topics[1].id | https://openalex.org/T12167 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9934999942779541 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1308 |
| topics[1].subfield.display_name | Clinical Biochemistry |
| topics[1].display_name | Bacterial Identification and Susceptibility Testing |
| topics[2].id | https://openalex.org/T12824 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9894999861717224 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1310 |
| topics[2].subfield.display_name | Endocrinology |
| topics[2].display_name | Infections and bacterial resistance |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2300 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C2777050379 |
| concepts[0].level | 5 |
| concepts[0].score | 0.7839202880859375 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2552927 |
| concepts[0].display_name | Cefepime |
| concepts[1].id | https://openalex.org/C2779375183 |
| concepts[1].level | 4 |
| concepts[1].score | 0.7523149251937866 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q421670 |
| concepts[1].display_name | Meropenem |
| concepts[2].id | https://openalex.org/C2779631663 |
| concepts[2].level | 4 |
| concepts[2].score | 0.7009601593017578 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q425152 |
| concepts[2].display_name | Imipenem |
| concepts[3].id | https://openalex.org/C2777317804 |
| concepts[3].level | 5 |
| concepts[3].score | 0.5699272155761719 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q67101192 |
| concepts[3].display_name | Porin |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.5592270493507385 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C2780950330 |
| concepts[5].level | 4 |
| concepts[5].score | 0.5582475066184998 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q19903614 |
| concepts[5].display_name | Broth microdilution |
| concepts[6].id | https://openalex.org/C2777058267 |
| concepts[6].level | 4 |
| concepts[6].score | 0.5528103709220886 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q132592 |
| concepts[6].display_name | Klebsiella pneumoniae |
| concepts[7].id | https://openalex.org/C535196362 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4883255660533905 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q758 |
| concepts[7].display_name | Zinc |
| concepts[8].id | https://openalex.org/C2776933286 |
| concepts[8].level | 4 |
| concepts[8].score | 0.444613516330719 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q132592 |
| concepts[8].display_name | Klebsiella pneumonia |
| concepts[9].id | https://openalex.org/C13965031 |
| concepts[9].level | 1 |
| concepts[9].score | 0.42490527033805847 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q243545 |
| concepts[9].display_name | Nuclear chemistry |
| concepts[10].id | https://openalex.org/C41685203 |
| concepts[10].level | 2 |
| concepts[10].score | 0.4175500273704529 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q1974042 |
| concepts[10].display_name | Docking (animal) |
| concepts[11].id | https://openalex.org/C176947019 |
| concepts[11].level | 3 |
| concepts[11].score | 0.38972049951553345 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q597889 |
| concepts[11].display_name | Minimum inhibitory concentration |
| concepts[12].id | https://openalex.org/C89423630 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3878757655620575 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7193 |
| concepts[12].display_name | Microbiology |
| concepts[13].id | https://openalex.org/C55493867 |
| concepts[13].level | 1 |
| concepts[13].score | 0.2450844645500183 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[13].display_name | Biochemistry |
| concepts[14].id | https://openalex.org/C86803240 |
| concepts[14].level | 0 |
| concepts[14].score | 0.23584404587745667 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[14].display_name | Biology |
| concepts[15].id | https://openalex.org/C94665300 |
| concepts[15].level | 3 |
| concepts[15].score | 0.19415926933288574 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q63391344 |
| concepts[15].display_name | Antibiotic resistance |
| concepts[16].id | https://openalex.org/C501593827 |
| concepts[16].level | 2 |
| concepts[16].score | 0.1817426085472107 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q12187 |
| concepts[16].display_name | Antibiotics |
| concepts[17].id | https://openalex.org/C178790620 |
| concepts[17].level | 1 |
| concepts[17].score | 0.17170515656471252 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[17].display_name | Organic chemistry |
| concepts[18].id | https://openalex.org/C146587185 |
| concepts[18].level | 4 |
| concepts[18].score | 0.1624279022216797 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q258248 |
| concepts[18].display_name | Bacterial outer membrane |
| concepts[19].id | https://openalex.org/C547475151 |
| concepts[19].level | 3 |
| concepts[19].score | 0.13833165168762207 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q25419 |
| concepts[19].display_name | Escherichia coli |
| concepts[20].id | https://openalex.org/C71924100 |
| concepts[20].level | 0 |
| concepts[20].score | 0.06817060708999634 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[20].display_name | Medicine |
| concepts[21].id | https://openalex.org/C159110408 |
| concepts[21].level | 1 |
| concepts[21].score | 0.0 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q121176 |
| concepts[21].display_name | Nursing |
| concepts[22].id | https://openalex.org/C104317684 |
| concepts[22].level | 2 |
| concepts[22].score | 0.0 |
| concepts[22].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[22].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/cefepime |
| keywords[0].score | 0.7839202880859375 |
| keywords[0].display_name | Cefepime |
| keywords[1].id | https://openalex.org/keywords/meropenem |
| keywords[1].score | 0.7523149251937866 |
| keywords[1].display_name | Meropenem |
| keywords[2].id | https://openalex.org/keywords/imipenem |
| keywords[2].score | 0.7009601593017578 |
| keywords[2].display_name | Imipenem |
| keywords[3].id | https://openalex.org/keywords/porin |
| keywords[3].score | 0.5699272155761719 |
| keywords[3].display_name | Porin |
| keywords[4].id | https://openalex.org/keywords/chemistry |
| keywords[4].score | 0.5592270493507385 |
| keywords[4].display_name | Chemistry |
| keywords[5].id | https://openalex.org/keywords/broth-microdilution |
| keywords[5].score | 0.5582475066184998 |
| keywords[5].display_name | Broth microdilution |
| keywords[6].id | https://openalex.org/keywords/klebsiella-pneumoniae |
| keywords[6].score | 0.5528103709220886 |
| keywords[6].display_name | Klebsiella pneumoniae |
| keywords[7].id | https://openalex.org/keywords/zinc |
| keywords[7].score | 0.4883255660533905 |
| keywords[7].display_name | Zinc |
| keywords[8].id | https://openalex.org/keywords/klebsiella-pneumonia |
| keywords[8].score | 0.444613516330719 |
| keywords[8].display_name | Klebsiella pneumonia |
| keywords[9].id | https://openalex.org/keywords/nuclear-chemistry |
| keywords[9].score | 0.42490527033805847 |
| keywords[9].display_name | Nuclear chemistry |
| keywords[10].id | https://openalex.org/keywords/docking |
| keywords[10].score | 0.4175500273704529 |
| keywords[10].display_name | Docking (animal) |
| keywords[11].id | https://openalex.org/keywords/minimum-inhibitory-concentration |
| keywords[11].score | 0.38972049951553345 |
| keywords[11].display_name | Minimum inhibitory concentration |
| keywords[12].id | https://openalex.org/keywords/microbiology |
| keywords[12].score | 0.3878757655620575 |
| keywords[12].display_name | Microbiology |
| keywords[13].id | https://openalex.org/keywords/biochemistry |
| keywords[13].score | 0.2450844645500183 |
| keywords[13].display_name | Biochemistry |
| keywords[14].id | https://openalex.org/keywords/biology |
| keywords[14].score | 0.23584404587745667 |
| keywords[14].display_name | Biology |
| keywords[15].id | https://openalex.org/keywords/antibiotic-resistance |
| keywords[15].score | 0.19415926933288574 |
| keywords[15].display_name | Antibiotic resistance |
| keywords[16].id | https://openalex.org/keywords/antibiotics |
| keywords[16].score | 0.1817426085472107 |
| keywords[16].display_name | Antibiotics |
| keywords[17].id | https://openalex.org/keywords/organic-chemistry |
| keywords[17].score | 0.17170515656471252 |
| keywords[17].display_name | Organic chemistry |
| keywords[18].id | https://openalex.org/keywords/bacterial-outer-membrane |
| keywords[18].score | 0.1624279022216797 |
| keywords[18].display_name | Bacterial outer membrane |
| keywords[19].id | https://openalex.org/keywords/escherichia-coli |
| keywords[19].score | 0.13833165168762207 |
| keywords[19].display_name | Escherichia coli |
| keywords[20].id | https://openalex.org/keywords/medicine |
| keywords[20].score | 0.06817060708999634 |
| keywords[20].display_name | Medicine |
| language | en |
| locations[0].id | doi:10.3390/molecules28062510 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S108911230 |
| locations[0].source.issn | 1420-3049, 1433-1373 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1420-3049 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Molecules |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1420-3049/28/6/2510/pdf?version=1678438819 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Molecules |
| locations[0].landing_page_url | https://doi.org/10.3390/molecules28062510 |
| locations[1].id | pmid:36985482 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Molecules (Basel, Switzerland) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36985482 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10055515 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10055515/pdf/molecules-28-02510.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Molecules |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10055515 |
| locations[3].id | pmh:oai:mdpi.com:/1420-3049/28/6/2510/ |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400947 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | True |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | MDPI (MDPI AG) |
| locations[3].source.host_organization | https://openalex.org/I4210097602 |
| locations[3].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Molecules; Volume 28; Issue 6; Pages: 2510 |
| locations[3].landing_page_url | https://dx.doi.org/10.3390/molecules28062510 |
| locations[4].id | pmh:oai:doaj.org/article:772e358a25ae4f109586df2d6241692d |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].source.host_organization_lineage | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Molecules, Vol 28, Iss 6, p 2510 (2023) |
| locations[4].landing_page_url | https://doaj.org/article/772e358a25ae4f109586df2d6241692d |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5022008788 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-6937-2588 |
| authorships[0].author.display_name | Rasha Elsayim |
| authorships[0].countries | SA |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I28022161 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia |
| authorships[0].institutions[0].id | https://openalex.org/I28022161 |
| authorships[0].institutions[0].ror | https://ror.org/02f81g417 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I28022161 |
| authorships[0].institutions[0].country_code | SA |
| authorships[0].institutions[0].display_name | King Saud University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Rasha Elsayim |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia |
| authorships[1].author.id | https://openalex.org/A5073081521 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-7712-0313 |
| authorships[1].author.display_name | Abeer S. Aloufi |
| authorships[1].countries | SA |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I106778892 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia |
| authorships[1].institutions[0].id | https://openalex.org/I106778892 |
| authorships[1].institutions[0].ror | https://ror.org/05b0cyh02 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I106778892 |
| authorships[1].institutions[0].country_code | SA |
| authorships[1].institutions[0].display_name | Princess Nourah bint Abdulrahman University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Abeer S. Aloufi |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia |
| authorships[2].author.id | https://openalex.org/A5007681653 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-4726-5631 |
| authorships[2].author.display_name | Yosra Modafer |
| authorships[2].countries | SA |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I91450128 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biology, College of Science, Jazan University, Jazan 45142, Saudi Arabia |
| authorships[2].institutions[0].id | https://openalex.org/I91450128 |
| authorships[2].institutions[0].ror | https://ror.org/02bjnq803 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I91450128 |
| authorships[2].institutions[0].country_code | SA |
| authorships[2].institutions[0].display_name | Jazan University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yosra Modafer |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biology, College of Science, Jazan University, Jazan 45142, Saudi Arabia |
| authorships[3].author.id | https://openalex.org/A5065566789 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-3981-201X |
| authorships[3].author.display_name | Wafa Ali Eltayb |
| authorships[3].countries | SD |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210126656 |
| authorships[3].affiliations[0].raw_affiliation_string | Biotechnology Department, Faculty of Science and Technology, Shendi University, Shendi 11111, Nher Anile, Sudan |
| authorships[3].institutions[0].id | https://openalex.org/I4210126656 |
| authorships[3].institutions[0].ror | https://ror.org/03ghc4a37 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210126656 |
| authorships[3].institutions[0].country_code | SD |
| authorships[3].institutions[0].display_name | Shendi University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Wafa Ali Eltayb |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Biotechnology Department, Faculty of Science and Technology, Shendi University, Shendi 11111, Nher Anile, Sudan |
| authorships[4].author.id | https://openalex.org/A5090182768 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-4073-2375 |
| authorships[4].author.display_name | Alaa Alnoor Alameen |
| authorships[4].countries | SA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I28022161 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia |
| authorships[4].institutions[0].id | https://openalex.org/I28022161 |
| authorships[4].institutions[0].ror | https://ror.org/02f81g417 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I28022161 |
| authorships[4].institutions[0].country_code | SA |
| authorships[4].institutions[0].display_name | King Saud University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Alaa Alnoor Alameen |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia |
| authorships[5].author.id | https://openalex.org/A5074221319 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-0626-8115 |
| authorships[5].author.display_name | Samah Awad Abdurahim |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Microbiology, College of Medicine, Al-Rayan Colleges, AL Madinah Al Monawara 41411, Saudi Arabia |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Samah Awad Abdurahim |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Microbiology, College of Medicine, Al-Rayan Colleges, AL Madinah Al Monawara 41411, Saudi Arabia |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1420-3049/28/6/2510/pdf?version=1678438819 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Molecular Dynamic Analysis of Carbapenem-Resistant Klebsiella pneumonia’s Porin Proteins with Beta Lactam Antibiotics and Zinc Oxide Nanoparticles |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10147 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1313 |
| primary_topic.subfield.display_name | Molecular Medicine |
| primary_topic.display_name | Antibiotic Resistance in Bacteria |
| related_works | https://openalex.org/W2790937404, https://openalex.org/W3212096935, https://openalex.org/W2107627260, https://openalex.org/W2115999525, https://openalex.org/W2744085349, https://openalex.org/W2945165328, https://openalex.org/W2141720283, https://openalex.org/W2347283549, https://openalex.org/W2171233401, https://openalex.org/W4323854054 |
| cited_by_count | 4 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/molecules28062510 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S108911230 |
| best_oa_location.source.issn | 1420-3049, 1433-1373 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1420-3049 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Molecules |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1420-3049/28/6/2510/pdf?version=1678438819 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Molecules |
| best_oa_location.landing_page_url | https://doi.org/10.3390/molecules28062510 |
| primary_location.id | doi:10.3390/molecules28062510 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S108911230 |
| primary_location.source.issn | 1420-3049, 1433-1373 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1420-3049 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Molecules |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1420-3049/28/6/2510/pdf?version=1678438819 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Molecules |
| primary_location.landing_page_url | https://doi.org/10.3390/molecules28062510 |
| publication_date | 2023-03-09 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2314586806, https://openalex.org/W2124110539, https://openalex.org/W2145111808, https://openalex.org/W2394651873, https://openalex.org/W2783804817, https://openalex.org/W3150902206, https://openalex.org/W2020923346, https://openalex.org/W2943757911, https://openalex.org/W6693040890, https://openalex.org/W2123677996, https://openalex.org/W3211846295, https://openalex.org/W1969289905, https://openalex.org/W2416783271, https://openalex.org/W3206620779, https://openalex.org/W2918226176, https://openalex.org/W2046743805, https://openalex.org/W6635868165, https://openalex.org/W118179289, https://openalex.org/W1967700164, https://openalex.org/W2530605349, https://openalex.org/W2804977066, https://openalex.org/W4296381285, https://openalex.org/W4283809268, https://openalex.org/W3085212187, https://openalex.org/W6803916410, https://openalex.org/W4280500119, https://openalex.org/W4212779438, https://openalex.org/W2990679896, https://openalex.org/W3194008544, https://openalex.org/W2130541969, https://openalex.org/W1965878806, https://openalex.org/W2887865837, https://openalex.org/W3089880084, https://openalex.org/W2019799507, https://openalex.org/W3129095230, https://openalex.org/W2263818957, https://openalex.org/W1598844438, https://openalex.org/W3215785552, https://openalex.org/W4293155640 |
| referenced_works_count | 39 |
| abstract_inverted_index.P | 182 |
| abstract_inverted_index.a | 29, 76, 137, 223, 305 |
| abstract_inverted_index.An | 218 |
| abstract_inverted_index.In | 131, 260 |
| abstract_inverted_index.MD | 153, 173, 219 |
| abstract_inverted_index.To | 0, 298 |
| abstract_inverted_index.ZI | 294 |
| abstract_inverted_index.as | 104, 106, 230 |
| abstract_inverted_index.be | 54 |
| abstract_inverted_index.by | 88, 118, 195, 232, 269 |
| abstract_inverted_index.do | 318 |
| abstract_inverted_index.in | 33, 86, 252, 286, 310, 324 |
| abstract_inverted_index.is | 10, 51, 304 |
| abstract_inverted_index.it | 9 |
| abstract_inverted_index.mm | 296 |
| abstract_inverted_index.ns | 239, 276 |
| abstract_inverted_index.of | 6, 19, 78, 92, 109, 139, 172, 215, 254, 264 |
| abstract_inverted_index.to | 12, 40, 53, 67, 312 |
| abstract_inverted_index.(24 | 295 |
| abstract_inverted_index.100 | 238, 275 |
| abstract_inverted_index.All | 206 |
| abstract_inverted_index.MBC | 290 |
| abstract_inverted_index.MIC | 287 |
| abstract_inverted_index.The | 17, 60, 113, 155, 241 |
| abstract_inverted_index.and | 37, 42, 57, 81, 99, 126, 147, 150, 169, 202, 209, 228, 234, 257, 293, 309 |
| abstract_inverted_index.are | 327 |
| abstract_inverted_index.for | 145, 152, 226, 247, 282 |
| abstract_inverted_index.had | 178 |
| abstract_inverted_index.has | 25 |
| abstract_inverted_index.how | 69 |
| abstract_inverted_index.log | 181 |
| abstract_inverted_index.new | 14 |
| abstract_inverted_index.not | 319 |
| abstract_inverted_index.the | 2, 90, 107, 161, 176, 179, 191, 262, 271, 300 |
| abstract_inverted_index.was | 134 |
| abstract_inverted_index.(0.2 | 288 |
| abstract_inverted_index.(0.5 | 291 |
| abstract_inverted_index.(MD) | 66 |
| abstract_inverted_index.KPC, | 284 |
| abstract_inverted_index.RMSD | 233 |
| abstract_inverted_index.RMSF | 235 |
| abstract_inverted_index.Vina | 144 |
| abstract_inverted_index.been | 26 |
| abstract_inverted_index.cell | 111 |
| abstract_inverted_index.draw | 299 |
| abstract_inverted_index.gulf | 34 |
| abstract_inverted_index.harm | 320 |
| abstract_inverted_index.more | 58 |
| abstract_inverted_index.rate | 32 |
| abstract_inverted_index.test | 242 |
| abstract_inverted_index.that | 158, 175, 302, 317 |
| abstract_inverted_index.then | 82 |
| abstract_inverted_index.this | 84 |
| abstract_inverted_index.used | 63 |
| abstract_inverted_index.vivo | 325 |
| abstract_inverted_index.well | 105 |
| abstract_inverted_index.were | 116, 164, 244, 267 |
| abstract_inverted_index.with | 28, 72, 160, 250 |
| abstract_inverted_index.zinc | 46 |
| abstract_inverted_index.zone | 91 |
| abstract_inverted_index.(IZ), | 94 |
| abstract_inverted_index.GLO21 | 162 |
| abstract_inverted_index.agent | 308 |
| abstract_inverted_index.bonds | 266 |
| abstract_inverted_index.drugs | 316 |
| abstract_inverted_index.green | 45 |
| abstract_inverted_index.human | 321 |
| abstract_inverted_index.ionic | 258 |
| abstract_inverted_index.order | 311 |
| abstract_inverted_index.oxide | 47 |
| abstract_inverted_index.porin | 73, 216, 251 |
| abstract_inverted_index.safer | 56 |
| abstract_inverted_index.sites | 214 |
| abstract_inverted_index.study | 62, 221 |
| abstract_inverted_index.terms | 253 |
| abstract_inverted_index.their | 248 |
| abstract_inverted_index.these | 265 |
| abstract_inverted_index.union | 35 |
| abstract_inverted_index.using | 136 |
| abstract_inverted_index.value | 183 |
| abstract_inverted_index.vitro | 87 |
| abstract_inverted_index.which | 186 |
| abstract_inverted_index.(MBC), | 103 |
| abstract_inverted_index.(MIC), | 98 |
| abstract_inverted_index.(SEM). | 130 |
| abstract_inverted_index.UV-Vis | 119 |
| abstract_inverted_index.ZnO-NP | 303 |
| abstract_inverted_index.cells, | 322 |
| abstract_inverted_index.during | 237 |
| abstract_inverted_index.higher | 30, 188 |
| abstract_inverted_index.ligand | 148 |
| abstract_inverted_index.potent | 306, 314 |
| abstract_inverted_index.showed | 222, 279 |
| abstract_inverted_index.silico | 132 |
| abstract_inverted_index.stable | 224 |
| abstract_inverted_index.system | 225 |
| abstract_inverted_index.target | 77 |
| abstract_inverted_index.tested | 83, 207 |
| abstract_inverted_index.values | 236 |
| abstract_inverted_index.within | 274 |
| abstract_inverted_index.(FTIR), | 125 |
| abstract_inverted_index.(−6.4 | 204 |
| abstract_inverted_index.(−7.5 | 200 |
| abstract_inverted_index.(−7.9 | 197 |
| abstract_inverted_index.(−9.1 | 184 |
| abstract_inverted_index.Desmond | 151 |
| abstract_inverted_index.KPC’s | 110 |
| abstract_inverted_index.ZnO-NPs | 70, 177, 210, 227, 278 |
| abstract_inverted_index.agents. | 16 |
| abstract_inverted_index.binding | 213 |
| abstract_inverted_index.contact | 273 |
| abstract_inverted_index.crucial | 11 |
| abstract_inverted_index.docking | 149 |
| abstract_inverted_index.examine | 68 |
| abstract_inverted_index.further | 245, 323 |
| abstract_inverted_index.highest | 180 |
| abstract_inverted_index.levels. | 259 |
| abstract_inverted_index.ligands | 157 |
| abstract_inverted_index.mg/mL), | 289, 292 |
| abstract_inverted_index.minimum | 95, 100 |
| abstract_inverted_index.possess | 211 |
| abstract_inverted_index.present | 61 |
| abstract_inverted_index.prevent | 1 |
| abstract_inverted_index.protein | 74, 146, 163 |
| abstract_inverted_index.rapidly | 3 |
| abstract_inverted_index.results | 281 |
| abstract_inverted_index.similar | 212 |
| abstract_inverted_index.studies | 326 |
| abstract_inverted_index.thought | 52 |
| abstract_inverted_index.through | 190 |
| abstract_inverted_index.variety | 138 |
| abstract_inverted_index.(GLO21), | 75 |
| abstract_inverted_index.(ZnO-NP) | 49 |
| abstract_inverted_index.Analysis | 171 |
| abstract_inverted_index.Autodock | 143 |
| abstract_inverted_index.Compared | 39 |
| abstract_inverted_index.ZnO-NPs, | 166 |
| abstract_inverted_index.cefepime | 196 |
| abstract_inverted_index.chemical | 43 |
| abstract_inverted_index.discover | 13 |
| abstract_inverted_index.dynamics | 65 |
| abstract_inverted_index.electron | 128 |
| abstract_inverted_index.fighting | 283 |
| abstract_inverted_index.followed | 194 |
| abstract_inverted_index.identify | 313 |
| abstract_inverted_index.imipenem | 203 |
| abstract_inverted_index.infrared | 123 |
| abstract_inverted_index.interact | 71, 159 |
| abstract_inverted_index.measured | 268 |
| abstract_inverted_index.physical | 41 |
| abstract_inverted_index.produced | 115 |
| abstract_inverted_index.revealed | 174 |
| abstract_inverted_index.scanning | 127 |
| abstract_inverted_index.surface, | 193 |
| abstract_inverted_index.surface. | 112 |
| abstract_inverted_index.addition, | 261 |
| abstract_inverted_index.bacterial | 7, 192 |
| abstract_inverted_index.candidate | 156 |
| abstract_inverted_index.cefepime, | 229 |
| abstract_inverted_index.cefepime. | 170 |
| abstract_inverted_index.compounds | 208, 243 |
| abstract_inverted_index.conducted | 135 |
| abstract_inverted_index.confirmed | 231 |
| abstract_inverted_index.countries | 36 |
| abstract_inverted_index.emergence | 18 |
| abstract_inverted_index.hydrogen, | 256 |
| abstract_inverted_index.imipenem, | 168 |
| abstract_inverted_index.including | 142 |
| abstract_inverted_index.indicates | 187 |
| abstract_inverted_index.inspected | 246 |
| abstract_inverted_index.meropenem | 199 |
| abstract_inverted_index.molecular | 64 |
| abstract_inverted_index.mortality | 31 |
| abstract_inverted_index.observing | 270 |
| abstract_inverted_index.promising | 280 |
| abstract_inverted_index.proteins. | 217 |
| abstract_inverted_index.required. | 328 |
| abstract_inverted_index.stability | 263 |
| abstract_inverted_index.synthesis | 50 |
| abstract_inverted_index.β-lactam | 79 |
| abstract_inverted_index.Klebsiella | 20 |
| abstract_inverted_index.alteration | 108 |
| abstract_inverted_index.associated | 27 |
| abstract_inverted_index.conclusion | 301 |
| abstract_inverted_index.diameter). | 297 |
| abstract_inverted_index.increasing | 4 |
| abstract_inverted_index.inhibition | 93 |
| abstract_inverted_index.inhibitory | 96 |
| abstract_inverted_index.kcal/mol), | 185, 198, 201 |
| abstract_inverted_index.kcal/mol). | 205 |
| abstract_inverted_index.meropenem, | 167 |
| abstract_inverted_index.microscopy | 129 |
| abstract_inverted_index.pneumoniae | 21 |
| abstract_inverted_index.prevalence | 5 |
| abstract_inverted_index.simulation | 220 |
| abstract_inverted_index.worldwide. | 38 |
| abstract_inverted_index.zetasizer, | 121 |
| abstract_inverted_index.approaches, | 44 |
| abstract_inverted_index.determining | 89 |
| abstract_inverted_index.interaction | 85 |
| abstract_inverted_index.represented | 285 |
| abstract_inverted_index.resistance, | 8 |
| abstract_inverted_index.simulation. | 154 |
| abstract_inverted_index.techniques, | 141 |
| abstract_inverted_index.antibiotics, | 80 |
| abstract_inverted_index.bactericidal | 101 |
| abstract_inverted_index.ecofriendly. | 59 |
| abstract_inverted_index.hydrophobic, | 255 |
| abstract_inverted_index.intersection | 249 |
| abstract_inverted_index.nanoparticle | 48 |
| abstract_inverted_index.permeability | 189 |
| abstract_inverted_index.spectroscopy | 124 |
| abstract_inverted_index.antibacterial | 15, 307, 315 |
| abstract_inverted_index.carbapenemase | 22 |
| abstract_inverted_index.characterized | 117 |
| abstract_inverted_index.computational | 140 |
| abstract_inverted_index.concentration | 97, 102 |
| abstract_inverted_index.investigation | 133 |
| abstract_inverted_index.nanoparticles | 114 |
| abstract_inverted_index.significantly | 55 |
| abstract_inverted_index.spectroscopy, | 120 |
| abstract_inverted_index.trajectories. | 240, 277 |
| abstract_inverted_index.biosynthesized | 165 |
| abstract_inverted_index.(KPC)-producing | 23 |
| abstract_inverted_index.protein–ligand | 272 |
| abstract_inverted_index.Fourier-transform | 122 |
| abstract_inverted_index.Enterobacteriaceae | 24 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5073081521 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I106778892 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/14 |
| sustainable_development_goals[0].score | 0.7699999809265137 |
| sustainable_development_goals[0].display_name | Life below water |
| citation_normalized_percentile.value | 0.54661773 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |