Molecular Insights on Shigellosis: How the Interaction Between Invasin IpaA and Vinculin Hijacks Cellular Mechanotransduction Article Swipe
Cristina Bertocchi
,
Nicole Morales
,
Andrea Ravasio
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.33594/000000631
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.33594/000000631
With 270 million infections annually and nearly half a million death a year, shigellosis is a severe intestinal infection caused by bacteria of the Shigella family. Appearance and spread of drug-resistant strains renewed global concerns for public health and finding novel targets for treatment is fast becoming a priority. To this end, invasins are a potentially good candidate. Also called Ipa(s), which is the short for Invasion Plasmid Antigen, invasins play a key role in mediating bacterial invasion and infection of the host cell. Importantly, they have been reported to hijack inbuilt mechanical capability of the host cells such as cell adhesion and active processes mediated by the actin cytoskeleton to enable bacterial ingress into the host cells. IpaA is an invasin of particular interest as it presents three motifs that mimic vinculin binding sites and thus it allows IpaA to interact with vinculin, which is one of the most critical regulators of cellular and tissue mechanics. Using a mechanobiology point-of-view, we aim to provide an overview of Shigella´s infection mechanism, to highlight recently discovered molecular mechanisms of IpaA/vinculin interaction and to finally discuss their consequences for epithelial cell and tissue mechanical homeostasis that may result in the symptomatic outcomes seen in severe shigellosis.
Related Topics
Concepts
Shigellosis
Vinculin
Shigella
Shigella flexneri
Biology
Cell biology
Microbiology
Actin
Actin cytoskeleton
Cytoskeleton
Cell
Focal adhesion
Bacteria
Genetics
Signal transduction
Escherichia coli
Gene
Salmonella
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.33594/000000631
- https://www.ppexmed.com/documents/000631.pdf
- OA Status
- bronze
- References
- 51
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4379014104Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.33594/000000631Digital Object Identifier
- Title
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Molecular Insights on Shigellosis: How the Interaction Between Invasin IpaA and Vinculin Hijacks Cellular MechanotransductionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-26Full publication date if available
- Authors
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Cristina Bertocchi, Nicole Morales, Andrea RavasioList of authors in order
- Landing page
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https://doi.org/10.33594/000000631Publisher landing page
- PDF URL
-
https://www.ppexmed.com/documents/000631.pdfDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://www.ppexmed.com/documents/000631.pdfDirect OA link when available
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Shigellosis, Vinculin, Shigella, Shigella flexneri, Biology, Cell biology, Microbiology, Actin, Actin cytoskeleton, Cytoskeleton, Cell, Focal adhesion, Bacteria, Genetics, Signal transduction, Escherichia coli, Gene, SalmonellaTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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