Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design Article Swipe
Durga Dharmadana
,
Nicholas P. Reynolds
,
Charlotte E. Conn
,
Céline Valéry
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1098/rsfs.2016.0160
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1098/rsfs.2016.0160
Amyloid nanofibrils are ubiquitous biological protein fibrous aggregates, with a wide range of either toxic or beneficial activities that are relevant to human disease and normal biology. Protein amyloid fibrillization occurs via nucleated polymerization, through non-covalent interactions. As such, protein nanofibril formation is based on a complex interplay between kinetic and thermodynamic factors. The process entails metastable oligomeric species and a highly thermodynamically favoured end state. The kinetics, and the reaction pathway itself, can be influenced by third party moieties, either molecules or surfaces. Specifically, in the biological context, different classes of biomolecules are known to act as catalysts, inhibitors or modifiers of the generic protein fibrillization process. The biological aggregation modifiers reviewed here include lipid membranes of varying composition, glycosaminoglycans and metal ions, with a final word on xenobiotic compounds. The corresponding molecular interactions are critically analysed and placed in the context of the mechanisms of cytotoxicity of the amyloids involved in diverse pathologies and the non-toxicity of functional amyloids (at least towards their biological host). Finally, the utilization of this knowledge towards the design of bio-inspired and biocompatible nanomaterials is explored.
Related Topics
Concepts
Context (archaeology)
Chemistry
Biomolecule
Amyloid (mycology)
Amyloid disease
Biocompatible material
Cytotoxicity
Biomaterial
Biophysics
Nanotechnology
Amyloid fibril
Biochemistry
Materials science
In vitro
Biology
Amyloid β
Organic chemistry
Paleontology
Medicine
Disease
Pathology
Biomedical engineering
Inorganic chemistry
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1098/rsfs.2016.0160
- OA Status
- green
- Cited By
- 30
- References
- 177
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2624790550
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2624790550Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1098/rsfs.2016.0160Digital Object Identifier
- Title
-
Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial designWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-06-16Full publication date if available
- Authors
-
Durga Dharmadana, Nicholas P. Reynolds, Charlotte E. Conn, Céline ValéryList of authors in order
- Landing page
-
https://doi.org/10.1098/rsfs.2016.0160Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/5474041Direct OA link when available
- Concepts
-
Context (archaeology), Chemistry, Biomolecule, Amyloid (mycology), Amyloid disease, Biocompatible material, Cytotoxicity, Biomaterial, Biophysics, Nanotechnology, Amyloid fibril, Biochemistry, Materials science, In vitro, Biology, Amyloid β, Organic chemistry, Paleontology, Medicine, Disease, Pathology, Biomedical engineering, Inorganic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 3, 2023: 2, 2022: 4, 2021: 5, 2020: 7Per-year citation counts (last 5 years)
- References (count)
-
177Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2624790550 |
|---|---|
| doi | https://doi.org/10.1098/rsfs.2016.0160 |
| ids.doi | https://doi.org/10.1098/rsfs.2016.0160 |
| ids.mag | 2624790550 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/28630679 |
| ids.openalex | https://openalex.org/W2624790550 |
| fwci | 3.09333678 |
| type | review |
| title | Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design |
| awards[0].id | https://openalex.org/G4810741513 |
| awards[0].funder_id | https://openalex.org/F4320320972 |
| awards[0].display_name | |
| awards[0].funder_award_id | RMIT PhD scholarship awarded to DD |
| awards[0].funder_display_name | RMIT University |
| awards[1].id | https://openalex.org/G1573337432 |
| awards[1].funder_id | https://openalex.org/F4320334704 |
| awards[1].display_name | |
| awards[1].funder_award_id | ARC DECRA Fellowship DE160101281 awarded to CEC |
| awards[1].funder_display_name | Australian Research Council |
| awards[2].id | https://openalex.org/G6516049150 |
| awards[2].funder_id | https://openalex.org/F4320334704 |
| awards[2].display_name | |
| awards[2].funder_award_id | ARC Training Centre for Biodevices at Swinburne Un |
| awards[2].funder_display_name | Australian Research Council |
| biblio.issue | 4 |
| biblio.volume | 7 |
| biblio.last_page | 20160160 |
| biblio.first_page | 20160160 |
| topics[0].id | https://openalex.org/T10086 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2737 |
| topics[0].subfield.display_name | Physiology |
| topics[0].display_name | Alzheimer's disease research and treatments |
| topics[1].id | https://openalex.org/T10044 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9969000220298767 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Protein Structure and Dynamics |
| topics[2].id | https://openalex.org/T11617 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9927999973297119 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1305 |
| topics[2].subfield.display_name | Biotechnology |
| topics[2].display_name | Enzyme Production and Characterization |
| funders[0].id | https://openalex.org/F4320320972 |
| funders[0].ror | https://ror.org/04ttjf776 |
| funders[0].display_name | RMIT University |
| funders[1].id | https://openalex.org/F4320334704 |
| funders[1].ror | https://ror.org/05mmh0f86 |
| funders[1].display_name | Australian Research Council |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2779343474 |
| concepts[0].level | 2 |
| concepts[0].score | 0.6576243042945862 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q3109175 |
| concepts[0].display_name | Context (archaeology) |
| concepts[1].id | https://openalex.org/C185592680 |
| concepts[1].level | 0 |
| concepts[1].score | 0.6117181777954102 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[1].display_name | Chemistry |
| concepts[2].id | https://openalex.org/C49853544 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5414999723434448 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q206229 |
| concepts[2].display_name | Biomolecule |
| concepts[3].id | https://openalex.org/C2777633098 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5297449827194214 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2736051 |
| concepts[3].display_name | Amyloid (mycology) |
| concepts[4].id | https://openalex.org/C2909607560 |
| concepts[4].level | 5 |
| concepts[4].score | 0.475207656621933 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q6740853 |
| concepts[4].display_name | Amyloid disease |
| concepts[5].id | https://openalex.org/C1318750 |
| concepts[5].level | 2 |
| concepts[5].score | 0.469072550535202 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q865663 |
| concepts[5].display_name | Biocompatible material |
| concepts[6].id | https://openalex.org/C109316439 |
| concepts[6].level | 3 |
| concepts[6].score | 0.44863057136535645 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q246181 |
| concepts[6].display_name | Cytotoxicity |
| concepts[7].id | https://openalex.org/C2778414984 |
| concepts[7].level | 2 |
| concepts[7].score | 0.44563060998916626 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q865663 |
| concepts[7].display_name | Biomaterial |
| concepts[8].id | https://openalex.org/C12554922 |
| concepts[8].level | 1 |
| concepts[8].score | 0.4229303002357483 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7100 |
| concepts[8].display_name | Biophysics |
| concepts[9].id | https://openalex.org/C171250308 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3646918535232544 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11468 |
| concepts[9].display_name | Nanotechnology |
| concepts[10].id | https://openalex.org/C2994168385 |
| concepts[10].level | 4 |
| concepts[10].score | 0.34742188453674316 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q6740853 |
| concepts[10].display_name | Amyloid fibril |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.30718815326690674 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| concepts[12].id | https://openalex.org/C192562407 |
| concepts[12].level | 0 |
| concepts[12].score | 0.19293224811553955 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[12].display_name | Materials science |
| concepts[13].id | https://openalex.org/C202751555 |
| concepts[13].level | 2 |
| concepts[13].score | 0.16819453239440918 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[13].display_name | In vitro |
| concepts[14].id | https://openalex.org/C86803240 |
| concepts[14].level | 0 |
| concepts[14].score | 0.16312947869300842 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[14].display_name | Biology |
| concepts[15].id | https://openalex.org/C3019447875 |
| concepts[15].level | 3 |
| concepts[15].score | 0.14166271686553955 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q417667 |
| concepts[15].display_name | Amyloid β |
| concepts[16].id | https://openalex.org/C178790620 |
| concepts[16].level | 1 |
| concepts[16].score | 0.09554848074913025 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[16].display_name | Organic chemistry |
| concepts[17].id | https://openalex.org/C151730666 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7205 |
| concepts[17].display_name | Paleontology |
| concepts[18].id | https://openalex.org/C71924100 |
| concepts[18].level | 0 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[18].display_name | Medicine |
| concepts[19].id | https://openalex.org/C2779134260 |
| concepts[19].level | 2 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[19].display_name | Disease |
| concepts[20].id | https://openalex.org/C142724271 |
| concepts[20].level | 1 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[20].display_name | Pathology |
| concepts[21].id | https://openalex.org/C136229726 |
| concepts[21].level | 1 |
| concepts[21].score | 0.0 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q327092 |
| concepts[21].display_name | Biomedical engineering |
| concepts[22].id | https://openalex.org/C179104552 |
| concepts[22].level | 1 |
| concepts[22].score | 0.0 |
| concepts[22].wikidata | https://www.wikidata.org/wiki/Q11165 |
| concepts[22].display_name | Inorganic chemistry |
| keywords[0].id | https://openalex.org/keywords/context |
| keywords[0].score | 0.6576243042945862 |
| keywords[0].display_name | Context (archaeology) |
| keywords[1].id | https://openalex.org/keywords/chemistry |
| keywords[1].score | 0.6117181777954102 |
| keywords[1].display_name | Chemistry |
| keywords[2].id | https://openalex.org/keywords/biomolecule |
| keywords[2].score | 0.5414999723434448 |
| keywords[2].display_name | Biomolecule |
| keywords[3].id | https://openalex.org/keywords/amyloid |
| keywords[3].score | 0.5297449827194214 |
| keywords[3].display_name | Amyloid (mycology) |
| keywords[4].id | https://openalex.org/keywords/amyloid-disease |
| keywords[4].score | 0.475207656621933 |
| keywords[4].display_name | Amyloid disease |
| keywords[5].id | https://openalex.org/keywords/biocompatible-material |
| keywords[5].score | 0.469072550535202 |
| keywords[5].display_name | Biocompatible material |
| keywords[6].id | https://openalex.org/keywords/cytotoxicity |
| keywords[6].score | 0.44863057136535645 |
| keywords[6].display_name | Cytotoxicity |
| keywords[7].id | https://openalex.org/keywords/biomaterial |
| keywords[7].score | 0.44563060998916626 |
| keywords[7].display_name | Biomaterial |
| keywords[8].id | https://openalex.org/keywords/biophysics |
| keywords[8].score | 0.4229303002357483 |
| keywords[8].display_name | Biophysics |
| keywords[9].id | https://openalex.org/keywords/nanotechnology |
| keywords[9].score | 0.3646918535232544 |
| keywords[9].display_name | Nanotechnology |
| keywords[10].id | https://openalex.org/keywords/amyloid-fibril |
| keywords[10].score | 0.34742188453674316 |
| keywords[10].display_name | Amyloid fibril |
| keywords[11].id | https://openalex.org/keywords/biochemistry |
| keywords[11].score | 0.30718815326690674 |
| keywords[11].display_name | Biochemistry |
| keywords[12].id | https://openalex.org/keywords/materials-science |
| keywords[12].score | 0.19293224811553955 |
| keywords[12].display_name | Materials science |
| keywords[13].id | https://openalex.org/keywords/in-vitro |
| keywords[13].score | 0.16819453239440918 |
| keywords[13].display_name | In vitro |
| keywords[14].id | https://openalex.org/keywords/biology |
| keywords[14].score | 0.16312947869300842 |
| keywords[14].display_name | Biology |
| keywords[15].id | https://openalex.org/keywords/amyloid-β |
| keywords[15].score | 0.14166271686553955 |
| keywords[15].display_name | Amyloid β |
| keywords[16].id | https://openalex.org/keywords/organic-chemistry |
| keywords[16].score | 0.09554848074913025 |
| keywords[16].display_name | Organic chemistry |
| language | en |
| locations[0].id | doi:10.1098/rsfs.2016.0160 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S2485448675 |
| locations[0].source.issn | 2042-8898, 2042-8901 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 2042-8898 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Interface Focus |
| locations[0].source.host_organization | https://openalex.org/P4310319787 |
| locations[0].source.host_organization_name | Royal Society |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319787 |
| locations[0].source.host_organization_lineage_names | Royal Society |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Interface Focus |
| locations[0].landing_page_url | https://doi.org/10.1098/rsfs.2016.0160 |
| locations[1].id | pmid:28630679 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Interface focus |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/28630679 |
| locations[2].id | pmh:oai:alma.61RMIT_INST:11247230430001341 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306402074 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | RMIT Research Repository (RMIT University Library) |
| locations[2].source.host_organization | https://openalex.org/I82951845 |
| locations[2].source.host_organization_name | RMIT University |
| locations[2].source.host_organization_lineage | https://openalex.org/I82951845 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | http://purl.org/au-research/grants/arc/IC140100023 |
| locations[3].id | pmh:oai:europepmc.org:5024969 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://europepmc.org/pmc/articles/PMC5474041 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:5474041 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Interface Focus |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5474041 |
| locations[5].id | pmh:oai:researchbank.swinburne.edu.au:04af9b1f-00d3-4c4b-a6b1-fe784b75f4c9/1 |
| locations[5].is_oa | False |
| locations[5].source.id | https://openalex.org/S4306401157 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | Swinburne Research Bank (Swinburne University of Technology) |
| locations[5].source.host_organization | https://openalex.org/I57093077 |
| locations[5].source.host_organization_name | Swinburne University of Technology |
| locations[5].source.host_organization_lineage | https://openalex.org/I57093077 |
| locations[5].license | |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | |
| locations[5].license_id | |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Interface Focus, Vol. 7, no. 4 (2017) |
| locations[5].landing_page_url | http://hdl.handle.net/1959.3/437630 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5014545492 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-4547-4712 |
| authorships[0].author.display_name | Durga Dharmadana |
| authorships[0].countries | AU |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I82951845 |
| authorships[0].affiliations[0].raw_affiliation_string | School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria 3001, Australia |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I82951845 |
| authorships[0].affiliations[1].raw_affiliation_string | School of Health and Biomedical Sciences, Discipline of Pharmaceutical Sciences, RMIT University, Bundoora, Melbourne, Victoria 3083, Australia |
| authorships[0].institutions[0].id | https://openalex.org/I82951845 |
| authorships[0].institutions[0].ror | https://ror.org/04ttjf776 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I82951845 |
| authorships[0].institutions[0].country_code | AU |
| authorships[0].institutions[0].display_name | RMIT University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Durga Dharmadana |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | School of Health and Biomedical Sciences, Discipline of Pharmaceutical Sciences, RMIT University, Bundoora, Melbourne, Victoria 3083, Australia, School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria 3001, Australia |
| authorships[1].author.id | https://openalex.org/A5047502336 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-4360-1335 |
| authorships[1].author.display_name | Nicholas P. Reynolds |
| authorships[1].countries | AU |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I57093077 |
| authorships[1].affiliations[0].raw_affiliation_string | ARC Training Centre for Biodevices, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, Victoria 3122, Australia |
| authorships[1].institutions[0].id | https://openalex.org/I57093077 |
| authorships[1].institutions[0].ror | https://ror.org/031rekg67 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I57093077 |
| authorships[1].institutions[0].country_code | AU |
| authorships[1].institutions[0].display_name | Swinburne University of Technology |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Nicholas P. Reynolds |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | ARC Training Centre for Biodevices, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, Victoria 3122, Australia |
| authorships[2].author.id | https://openalex.org/A5067713493 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-3362-3453 |
| authorships[2].author.display_name | Charlotte E. Conn |
| authorships[2].countries | AU |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I82951845 |
| authorships[2].affiliations[0].raw_affiliation_string | School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria 3001, Australia |
| authorships[2].institutions[0].id | https://openalex.org/I82951845 |
| authorships[2].institutions[0].ror | https://ror.org/04ttjf776 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I82951845 |
| authorships[2].institutions[0].country_code | AU |
| authorships[2].institutions[0].display_name | RMIT University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Charlotte E. Conn |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria 3001, Australia |
| authorships[3].author.id | https://openalex.org/A5060559462 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-4724-3651 |
| authorships[3].author.display_name | Céline Valéry |
| authorships[3].countries | AU |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I82951845 |
| authorships[3].affiliations[0].raw_affiliation_string | School of Health and Biomedical Sciences, Discipline of Pharmaceutical Sciences, RMIT University, Bundoora, Melbourne, Victoria 3083, Australia |
| authorships[3].institutions[0].id | https://openalex.org/I82951845 |
| authorships[3].institutions[0].ror | https://ror.org/04ttjf776 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I82951845 |
| authorships[3].institutions[0].country_code | AU |
| authorships[3].institutions[0].display_name | RMIT University |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Céline Valéry |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | School of Health and Biomedical Sciences, Discipline of Pharmaceutical Sciences, RMIT University, Bundoora, Melbourne, Victoria 3083, Australia |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5474041 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10086 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2737 |
| primary_topic.subfield.display_name | Physiology |
| primary_topic.display_name | Alzheimer's disease research and treatments |
| related_works | https://openalex.org/W4387060860, https://openalex.org/W2062218714, https://openalex.org/W2082165927, https://openalex.org/W2128145834, https://openalex.org/W4392509751, https://openalex.org/W1553579345, https://openalex.org/W2398732346, https://openalex.org/W2105598295, https://openalex.org/W2132571966, https://openalex.org/W4323848845 |
| cited_by_count | 30 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 4 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 5 |
| counts_by_year[4].year | 2020 |
| counts_by_year[4].cited_by_count | 7 |
| counts_by_year[5].year | 2019 |
| counts_by_year[5].cited_by_count | 2 |
| counts_by_year[6].year | 2018 |
| counts_by_year[6].cited_by_count | 5 |
| counts_by_year[7].year | 2017 |
| counts_by_year[7].cited_by_count | 2 |
| locations_count | 6 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:5474041 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Interface Focus |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/5474041 |
| primary_location.id | doi:10.1098/rsfs.2016.0160 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S2485448675 |
| primary_location.source.issn | 2042-8898, 2042-8901 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 2042-8898 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Interface Focus |
| primary_location.source.host_organization | https://openalex.org/P4310319787 |
| primary_location.source.host_organization_name | Royal Society |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319787 |
| primary_location.source.host_organization_lineage_names | Royal Society |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Interface Focus |
| primary_location.landing_page_url | https://doi.org/10.1098/rsfs.2016.0160 |
| publication_date | 2017-06-16 |
| publication_year | 2017 |
| referenced_works | https://openalex.org/W2024895112, https://openalex.org/W2076834744, https://openalex.org/W2516762926, https://openalex.org/W2085899859, https://openalex.org/W2154721456, https://openalex.org/W1856532105, https://openalex.org/W2057709942, https://openalex.org/W2143295806, https://openalex.org/W2046093999, https://openalex.org/W2555151293, https://openalex.org/W2146656482, https://openalex.org/W2021785060, https://openalex.org/W2031007679, https://openalex.org/W2129115026, https://openalex.org/W2038673804, https://openalex.org/W2087654804, https://openalex.org/W2143986369, https://openalex.org/W2144068388, https://openalex.org/W1870920051, https://openalex.org/W1984569087, https://openalex.org/W6633228889, https://openalex.org/W2164995600, https://openalex.org/W1974059817, https://openalex.org/W2082314807, https://openalex.org/W2317714996, https://openalex.org/W2340097512, https://openalex.org/W2058469726, https://openalex.org/W2067586932, https://openalex.org/W1982675913, https://openalex.org/W2121977115, https://openalex.org/W2085687763, https://openalex.org/W2025607001, https://openalex.org/W896868469, https://openalex.org/W2068334126, https://openalex.org/W2097965815, https://openalex.org/W2129320185, https://openalex.org/W1975445752, https://openalex.org/W2056324592, https://openalex.org/W2326329626, https://openalex.org/W1984876762, https://openalex.org/W2078010704, https://openalex.org/W2063827082, https://openalex.org/W2165021720, https://openalex.org/W2100610042, https://openalex.org/W2042036635, https://openalex.org/W1995272223, https://openalex.org/W2149081087, https://openalex.org/W2083920564, https://openalex.org/W2052794643, https://openalex.org/W2033451537, https://openalex.org/W2054043866, https://openalex.org/W2007003497, https://openalex.org/W2035512416, https://openalex.org/W2055462017, https://openalex.org/W2067008646, https://openalex.org/W1975311211, https://openalex.org/W2010531966, https://openalex.org/W2044448989, https://openalex.org/W2145124130, https://openalex.org/W2007922488, https://openalex.org/W1995191747, https://openalex.org/W2121963977, https://openalex.org/W2084280842, https://openalex.org/W2026497992, https://openalex.org/W1956133826, https://openalex.org/W1968077397, https://openalex.org/W2070004512, https://openalex.org/W2046188801, https://openalex.org/W2064581913, https://openalex.org/W1974677010, https://openalex.org/W2313071809, https://openalex.org/W2106343176, https://openalex.org/W2155653247, https://openalex.org/W2087861584, https://openalex.org/W2020796799, https://openalex.org/W2133272695, https://openalex.org/W2082038580, https://openalex.org/W2073810813, https://openalex.org/W1973504417, https://openalex.org/W2129412868, https://openalex.org/W2508462701, https://openalex.org/W2121342475, https://openalex.org/W1965888147, https://openalex.org/W1535963221, https://openalex.org/W2000075190, https://openalex.org/W1969091108, https://openalex.org/W1964741996, https://openalex.org/W1971116939, https://openalex.org/W1989176019, https://openalex.org/W2060594859, https://openalex.org/W2020550176, https://openalex.org/W2144617447, https://openalex.org/W2073298789, https://openalex.org/W1979147091, https://openalex.org/W2005622137, https://openalex.org/W2041137224, https://openalex.org/W1998038512, https://openalex.org/W1988437687, https://openalex.org/W2094199966, https://openalex.org/W2230622832, https://openalex.org/W2312528904, https://openalex.org/W1990542024, https://openalex.org/W1994355482, https://openalex.org/W2106638887, https://openalex.org/W2508097088, https://openalex.org/W2028711659, https://openalex.org/W2058213249, https://openalex.org/W2109099861, https://openalex.org/W2164833764, https://openalex.org/W2019428611, https://openalex.org/W2150561062, https://openalex.org/W2053400919, https://openalex.org/W2014485936, https://openalex.org/W2104546775, https://openalex.org/W2032018161, https://openalex.org/W2145258357, https://openalex.org/W2290712951, https://openalex.org/W2090716049, https://openalex.org/W2103997070, https://openalex.org/W2040396361, https://openalex.org/W2142436715, https://openalex.org/W2272362840, https://openalex.org/W1994282166, https://openalex.org/W2009827441, https://openalex.org/W2154990910, https://openalex.org/W2015684005, https://openalex.org/W2033818437, https://openalex.org/W1852473213, https://openalex.org/W2014290130, https://openalex.org/W2083542002, https://openalex.org/W1976017046, https://openalex.org/W1966721430, https://openalex.org/W2120671345, https://openalex.org/W1985073653, https://openalex.org/W2033083169, https://openalex.org/W2040178046, https://openalex.org/W2018891401, https://openalex.org/W157666778, https://openalex.org/W2115891976, https://openalex.org/W1970159001, https://openalex.org/W2017268270, https://openalex.org/W1989810100, https://openalex.org/W2148225540, https://openalex.org/W2405653883, https://openalex.org/W1985891852, https://openalex.org/W2090718260, https://openalex.org/W1980357013, https://openalex.org/W2012108930, https://openalex.org/W2002330213, https://openalex.org/W1982360614, https://openalex.org/W2302067748, https://openalex.org/W2148202722, https://openalex.org/W1981471614, https://openalex.org/W2319987871, https://openalex.org/W2325973372, https://openalex.org/W2173381099, https://openalex.org/W2154807901, https://openalex.org/W2409849469, https://openalex.org/W2313136838, https://openalex.org/W2059004813, https://openalex.org/W2008698790, https://openalex.org/W1970736092, https://openalex.org/W2382261180, https://openalex.org/W2023614424, https://openalex.org/W2304963923, https://openalex.org/W2094563951, https://openalex.org/W759837351, https://openalex.org/W2158907165, https://openalex.org/W1996927016, https://openalex.org/W1756354197, https://openalex.org/W2062440115, https://openalex.org/W2160145354, https://openalex.org/W2160647863, https://openalex.org/W2063975915, https://openalex.org/W4210262992, https://openalex.org/W1553877445, https://openalex.org/W2786731180 |
| referenced_works_count | 177 |
| abstract_inverted_index.a | 9, 45, 60, 125 |
| abstract_inverted_index.As | 37 |
| abstract_inverted_index.as | 97 |
| abstract_inverted_index.be | 74 |
| abstract_inverted_index.by | 76 |
| abstract_inverted_index.in | 85, 140, 152 |
| abstract_inverted_index.is | 42, 181 |
| abstract_inverted_index.of | 12, 91, 102, 117, 143, 146, 148, 158, 170, 176 |
| abstract_inverted_index.on | 44, 128 |
| abstract_inverted_index.or | 15, 82, 100 |
| abstract_inverted_index.to | 21, 95 |
| abstract_inverted_index.(at | 161 |
| abstract_inverted_index.The | 53, 66, 108, 131 |
| abstract_inverted_index.act | 96 |
| abstract_inverted_index.and | 24, 50, 59, 68, 121, 138, 155, 178 |
| abstract_inverted_index.are | 2, 19, 93, 135 |
| abstract_inverted_index.can | 73 |
| abstract_inverted_index.end | 64 |
| abstract_inverted_index.the | 69, 86, 103, 141, 144, 149, 156, 168, 174 |
| abstract_inverted_index.via | 31 |
| abstract_inverted_index.here | 113 |
| abstract_inverted_index.that | 18 |
| abstract_inverted_index.this | 171 |
| abstract_inverted_index.wide | 10 |
| abstract_inverted_index.with | 8, 124 |
| abstract_inverted_index.word | 127 |
| abstract_inverted_index.based | 43 |
| abstract_inverted_index.final | 126 |
| abstract_inverted_index.human | 22 |
| abstract_inverted_index.ions, | 123 |
| abstract_inverted_index.known | 94 |
| abstract_inverted_index.least | 162 |
| abstract_inverted_index.lipid | 115 |
| abstract_inverted_index.metal | 122 |
| abstract_inverted_index.party | 78 |
| abstract_inverted_index.range | 11 |
| abstract_inverted_index.such, | 38 |
| abstract_inverted_index.their | 164 |
| abstract_inverted_index.third | 77 |
| abstract_inverted_index.toxic | 14 |
| abstract_inverted_index.design | 175 |
| abstract_inverted_index.either | 13, 80 |
| abstract_inverted_index.highly | 61 |
| abstract_inverted_index.host). | 166 |
| abstract_inverted_index.normal | 25 |
| abstract_inverted_index.occurs | 30 |
| abstract_inverted_index.placed | 139 |
| abstract_inverted_index.state. | 65 |
| abstract_inverted_index.Amyloid | 0 |
| abstract_inverted_index.Protein | 27 |
| abstract_inverted_index.amyloid | 28 |
| abstract_inverted_index.between | 48 |
| abstract_inverted_index.classes | 90 |
| abstract_inverted_index.complex | 46 |
| abstract_inverted_index.context | 142 |
| abstract_inverted_index.disease | 23 |
| abstract_inverted_index.diverse | 153 |
| abstract_inverted_index.entails | 55 |
| abstract_inverted_index.fibrous | 6 |
| abstract_inverted_index.generic | 104 |
| abstract_inverted_index.include | 114 |
| abstract_inverted_index.itself, | 72 |
| abstract_inverted_index.kinetic | 49 |
| abstract_inverted_index.pathway | 71 |
| abstract_inverted_index.process | 54 |
| abstract_inverted_index.protein | 5, 39, 105 |
| abstract_inverted_index.species | 58 |
| abstract_inverted_index.through | 34 |
| abstract_inverted_index.towards | 163, 173 |
| abstract_inverted_index.varying | 118 |
| abstract_inverted_index.Finally, | 167 |
| abstract_inverted_index.amyloids | 150, 160 |
| abstract_inverted_index.analysed | 137 |
| abstract_inverted_index.biology. | 26 |
| abstract_inverted_index.context, | 88 |
| abstract_inverted_index.factors. | 52 |
| abstract_inverted_index.favoured | 63 |
| abstract_inverted_index.involved | 151 |
| abstract_inverted_index.process. | 107 |
| abstract_inverted_index.reaction | 70 |
| abstract_inverted_index.relevant | 20 |
| abstract_inverted_index.reviewed | 112 |
| abstract_inverted_index.different | 89 |
| abstract_inverted_index.explored. | 182 |
| abstract_inverted_index.formation | 41 |
| abstract_inverted_index.interplay | 47 |
| abstract_inverted_index.kinetics, | 67 |
| abstract_inverted_index.knowledge | 172 |
| abstract_inverted_index.membranes | 116 |
| abstract_inverted_index.modifiers | 101, 111 |
| abstract_inverted_index.moieties, | 79 |
| abstract_inverted_index.molecular | 133 |
| abstract_inverted_index.molecules | 81 |
| abstract_inverted_index.nucleated | 32 |
| abstract_inverted_index.surfaces. | 83 |
| abstract_inverted_index.activities | 17 |
| abstract_inverted_index.beneficial | 16 |
| abstract_inverted_index.biological | 4, 87, 109, 165 |
| abstract_inverted_index.catalysts, | 98 |
| abstract_inverted_index.compounds. | 130 |
| abstract_inverted_index.critically | 136 |
| abstract_inverted_index.functional | 159 |
| abstract_inverted_index.influenced | 75 |
| abstract_inverted_index.inhibitors | 99 |
| abstract_inverted_index.mechanisms | 145 |
| abstract_inverted_index.metastable | 56 |
| abstract_inverted_index.nanofibril | 40 |
| abstract_inverted_index.oligomeric | 57 |
| abstract_inverted_index.ubiquitous | 3 |
| abstract_inverted_index.xenobiotic | 129 |
| abstract_inverted_index.aggregates, | 7 |
| abstract_inverted_index.aggregation | 110 |
| abstract_inverted_index.nanofibrils | 1 |
| abstract_inverted_index.pathologies | 154 |
| abstract_inverted_index.utilization | 169 |
| abstract_inverted_index.bio-inspired | 177 |
| abstract_inverted_index.biomolecules | 92 |
| abstract_inverted_index.composition, | 119 |
| abstract_inverted_index.cytotoxicity | 147 |
| abstract_inverted_index.interactions | 134 |
| abstract_inverted_index.non-covalent | 35 |
| abstract_inverted_index.non-toxicity | 157 |
| abstract_inverted_index.Specifically, | 84 |
| abstract_inverted_index.biocompatible | 179 |
| abstract_inverted_index.corresponding | 132 |
| abstract_inverted_index.interactions. | 36 |
| abstract_inverted_index.nanomaterials | 180 |
| abstract_inverted_index.thermodynamic | 51 |
| abstract_inverted_index.fibrillization | 29, 106 |
| abstract_inverted_index.polymerization, | 33 |
| abstract_inverted_index.thermodynamically | 62 |
| abstract_inverted_index.glycosaminoglycans | 120 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5060559462 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I82951845 |
| citation_normalized_percentile.value | 0.88700394 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |