Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by Epiprofin Article Swipe
Takashi Nakamura
,
H Nakamura
,
Y. Iwasaki
,
Motomi Enomoto‐Iwamoto
,
Noriaki Nakashima
,
Satoshi Fukumoto
,
Maurizio Pacifici
,
Masahiro Iwamoto
,
Minoru Wakamori
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/febs.70085
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/febs.70085
Epiprofin (Epfn), an Sp/KLF family transcription factor that regulates cell proliferation and determines cell fates, is essential for normal skin, hair follicle, and tooth development. We found that Epfn was expressed in parathyroid glands, and Epfn‐ knockout mice displayed elevated serum parathyroid hormone (PTH) concentrations, decreased bone volume, and intracranial ectopic calcification. To investigate the role of Epfn in the regulation of PTH expression, parathyroid gland explant and parathyroid cell line culture methods were used. Epfn expression was found to be upregulated in response to an increase in extracellular calcium concentration, whereas PTH expression was downregulated, thus demonstrating an inverse correlation. Forced expression of Epfn inhibited PTH gene expression and PTH promoter reporter activity in parathyroid cells. In addition, with a high extracellular calcium concentration, Epfn silencing in cultured parathyroid glands failed to block PTH gene expression. ChIP‐qPCR analysis also revealed Epfn binding in the proximal region of the PTH promoter, which was accelerated in the presence of a high concentration of calcium ions. The results from our in vitro and ex vivo analyses suggest that Epfn is a newly identified negative regulator of PTH transcription by regulating the proximal PTH promoter. Furthermore, the expression of Epfn was significantly reduced in parathyroid adenomas of primary hyperparathyroidism patients. The identification of Epfn as a potential therapeutic target for the control of PTH production in hyperparathyroidism patients opens new avenues for targeted treatment approaches.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/febs.70085
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70085
- OA Status
- hybrid
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- 1
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- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409052313
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409052313Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/febs.70085Digital Object Identifier
- Title
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Molecular mechanism for transcriptional regulation of the parathyroid hormone gene by EpiprofinWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-31Full publication date if available
- Authors
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Takashi Nakamura, H Nakamura, Y. Iwasaki, Motomi Enomoto‐Iwamoto, Noriaki Nakashima, Satoshi Fukumoto, Maurizio Pacifici, Masahiro Iwamoto, Minoru WakamoriList of authors in order
- Landing page
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https://doi.org/10.1111/febs.70085Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70085Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70085Direct OA link when available
- Concepts
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Parathyroid hormone, Internal medicine, Endocrinology, Hyperparathyroidism, Parathyroid chief cell, Gene expression, Biology, Primary hyperparathyroidism, Calcium metabolism, Gene silencing, Calcium, Chemistry, Gene, Medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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