Molecular Mechanism of the β-Lactamase Mediated β-Lactam Antibiotic Resistance of Pseudomonas aeruginosa Isolated From a Chinese Teaching Hospital Article Swipe
Hailong Lin
,
Chunlin Feng
,
Tingting Zhu
,
Anqi Li
,
Shuang Liu
,
Lei Zhang
,
Qiaoling Li
,
Xueya Zhang
,
Li Lin
,
Junwan Lu
,
Xi Lin
,
Kewei Li
,
Hailin Zhang
,
Teng Xu
,
Changchong Li
,
Qiyu Bao
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2022.855961
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2022.855961
Pseudomonas aeruginosa can cause infections in the blood, lungs (pneumonia), or other parts of the body after surgery. To investigate the molecular characteristics of β-lactam antibiotic resistance of P. aeruginosa isolated from a hospital population between 2015 and 2017, in this study, the antimicrobial susceptibility and the resistance gene profile of the bacteria were determined. The Pulsed-field gel electrophoresis (PFGE) was used to characterize the clonal relatedness and sequencing and comparative genomic analysis were performed to analyze the structure of the resistance gene-related sequences. As a result, of the 260 P . aeruginosa strains analyzed, the resistance rates for 6 β-lactam antibiotics ranged from 4.6 to 9.6%. A total of 7 genotypes of 44 β-lactamase genes were identified in 23 isolates (8.9%, 23/260). Four transconjugants from different donors carrying bla CARB-3 exhibited a phenotype of reduced susceptibility to piperacillin–tazobactam, ceftazidime, and cefepime, and 2 transconjugants harboring bla IMP-45 exhibited a phenotype of reduced susceptibility to carbapenems. bla CARB positive isolates ( n = 12) presented six PFGE patterns, designated groups A to F. Two bla genes ( bla IMP-45 and bla OXA-1 ) in PA1609 related to a class 1 integron ( intI1 - bla IMP-45- bla OXA-1 - aac(6′)-Ib7 - catB3 - qacE∆1 - sul1 ) were encoded on a plasmid (pPA1609-475), while the bla CARB-3 gene of PA1616 also related to a class 1 integron was located on the chromosome. The results suggest that β-lactam antibiotic resistance and clonal dissemination exist in this hospital population. It indicates the necessity for molecular surveillance in tracking β-lactamase-producing strains and emphasizes the need for epidemiological monitoring.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2022.855961
- https://www.frontiersin.org/articles/10.3389/fmicb.2022.855961/pdf
- OA Status
- gold
- Cited By
- 9
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4224983272
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4224983272Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fmicb.2022.855961Digital Object Identifier
- Title
-
Molecular Mechanism of the β-Lactamase Mediated β-Lactam Antibiotic Resistance of Pseudomonas aeruginosa Isolated From a Chinese Teaching HospitalWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-04-28Full publication date if available
- Authors
-
Hailong Lin, Chunlin Feng, Tingting Zhu, Anqi Li, Shuang Liu, Lei Zhang, Qiaoling Li, Xueya Zhang, Li Lin, Junwan Lu, Xi Lin, Kewei Li, Hailin Zhang, Teng Xu, Changchong Li, Qiyu BaoList of authors in order
- Landing page
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https://doi.org/10.3389/fmicb.2022.855961Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fmicb.2022.855961/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fmicb.2022.855961/pdfDirect OA link when available
- Concepts
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Pseudomonas aeruginosa, Microbiology, Antibiotics, Antibiotic resistance, Mechanism (biology), Biology, Lactam, Pseudomonas, Chemistry, Bacteria, Genetics, Stereochemistry, Philosophy, EpistemologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 3, 2023: 4, 2022: 1Per-year citation counts (last 5 years)
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35Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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