Molecular Signatures of Obesity-Associated Infertility in Polycystic Ovary Syndrome: The Emerging Role of Exosomal microRNAs and Non-Coding RNAs Article Swipe
Charalampos Voros
,
George K. Papadimas
,
Despoina Mavrogianni
,
Aristotelis-Marios Koulakmanidis
,
Diamantis Athanasiou
,
Kyriakos Bananis
,
Antonia Athanasiou
,
Aikaterini Athanasiou
,
Ioannis Papapanagiotou
,
Dimitrios Vaitsis
,
Charalampos Τsimpoukelis
,
Maria Anastasia Daskalaki
,
Vasileios Topalis
,
Marianna Theodora
,
Nikolaos Thomakos
,
Fotios Chatzinikolaou
,
Panagiotis Antsaklis
,
D. Loutradis
,
Evangelos Menenakos
,
G. Daskalakis
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/genes16091101
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/genes16091101
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine and metabolic conditions affecting women of reproductive age. This condition affects around 20% of this demographic and is characterized by polycystic ovarian morphology, hyperandrogenism, and chronic anovulation. Obesity, impacting 40–85% of women with PCOS, exacerbates insulin resistance, increases insulin levels, and intensifies low-grade inflammation. This exacerbates the reproductive and metabolic complications associated with the condition. Recent advancements in molecular biology have underscored the significance of non-coding RNAs, including as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), as crucial regulators of gene expression and prospective biomarkers for PCOS. Exosome-derived microRNAs (ex-miRNAs) have emerged as compelling candidates due to their stability in body fluids and their capacity to promote intercellular communication among adipose tissue, the ovary, and the endometrium. Research, encompassing both experimental and clinical studies, has shown that ex-miRNAs display differing expression levels in women with obesity-related PCOS. Several of these ex-miRNAs are associated with networks that govern inflammation, glucose metabolism, steroidogenesis, and folliculogenesis. Moreover, the encapsulation of these chemicals within exosomes safeguards them from enzymatic breakdown, hence augmenting their potential as non-invasive biomarkers for diagnosis, prognosis, and treatment monitoring. Despite the initial results being encouraging, challenges remain in standardising exosome separation, quantifying miRNA, and analyzing functional data within the complex pathophysiology of PCOS. This narrative review consolidates existing evidence regarding the molecular signatures of obesity-related infertility in PCOS, emphasising the growing significance of exosomal miRNAs and other non-coding RNAs, while examining their translational potential for early diagnosis and personalised therapeutic approaches.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/genes16091101
- https://www.mdpi.com/2073-4425/16/9/1101/pdf?version=1758167214
- OA Status
- gold
- Cited By
- 1
- References
- 241
- OpenAlex ID
- https://openalex.org/W4414284242
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4414284242Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/genes16091101Digital Object Identifier
- Title
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Molecular Signatures of Obesity-Associated Infertility in Polycystic Ovary Syndrome: The Emerging Role of Exosomal microRNAs and Non-Coding RNAsWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-17Full publication date if available
- Authors
-
Charalampos Voros, George K. Papadimas, Despoina Mavrogianni, Aristotelis-Marios Koulakmanidis, Diamantis Athanasiou, Kyriakos Bananis, Antonia Athanasiou, Aikaterini Athanasiou, Ioannis Papapanagiotou, Dimitrios Vaitsis, Charalampos Τsimpoukelis, Maria Anastasia Daskalaki, Vasileios Topalis, Marianna Theodora, Nikolaos Thomakos, Fotios Chatzinikolaou, Panagiotis Antsaklis, D. Loutradis, Evangelos Menenakos, G. DaskalakisList of authors in order
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-
https://doi.org/10.3390/genes16091101Publisher landing page
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-
https://www.mdpi.com/2073-4425/16/9/1101/pdf?version=1758167214Direct link to full text PDF
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-
YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2073-4425/16/9/1101/pdf?version=1758167214Direct OA link when available
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
- References (count)
-
241Number of works referenced by this work
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