Molecule engineering of coumarin to reverse aggregation-caused quenching: Facile access to BioAIEgens Article Swipe
Shouji Li
,
Xiaobin Li
,
Junyu Liu
,
Yuting Lin
,
Xuedan Zhang
,
Weiren Zhong
,
Juan Li
,
Caifa You
,
Dong Wang
,
Jianghong ZHANG
,
Xu Xu
,
Xu‐Min Cai
,
Can Yang Zhang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.isci.2025.112520
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.isci.2025.112520
Aggregation-induced emission luminogens (AIEgens) have been extensively investigated and widely used in biomedical fields. However, AIEgens are mostly derived from petrochemicals, leading to challenges of renewability, sustainability, and biocompatibility. Therefore, it is of striking prospect to construct bioproduct-based AIEgens (BioAIEgens) based on the natural profits. Herein, we proposed a straightforward method named "rotor-alicyclic" strategy to prepare BioAIEgens with high fluorescence and produce reactive oxygen species (ROS) activities as well as high biosafety. We prepared four BioAIEgens by introducing two rotors and a naturally rigid alicyclic moiety into coumarin molecule. The aggregation-induced emission (AIE) performances were evaluated, especially the fluorescence and production of ROS activities. Mechanistic study proved that the introduction of two rotors can destroy the planar structure, and the rigid alicyclic moiety can limit the molecular motion. Furthermore, the biosafety was carefully investigated in vitro and in vivo, demonstrating the high biocompatibility. Summarily, we developed a facile engineering method to prepare BioAIEgens.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.isci.2025.112520
- OA Status
- gold
- Cited By
- 1
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409816246
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409816246Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.isci.2025.112520Digital Object Identifier
- Title
-
Molecule engineering of coumarin to reverse aggregation-caused quenching: Facile access to BioAIEgensWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-04-24Full publication date if available
- Authors
-
Shouji Li, Xiaobin Li, Junyu Liu, Yuting Lin, Xuedan Zhang, Weiren Zhong, Juan Li, Caifa You, Dong Wang, Jianghong ZHANG, Xu Xu, Xu‐Min Cai, Can Yang ZhangList of authors in order
- Landing page
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https://doi.org/10.1016/j.isci.2025.112520Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.isci.2025.112520Direct OA link when available
- Concepts
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Coumarin, Quenching (fluorescence), Chemistry, Combinatorial chemistry, Nanotechnology, Fluorescence, Organic chemistry, Materials science, Physics, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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