Monitoring ZEO apoptotic potential in 2D and 3D cell cultures and associated spectroscopic evidence on mode of interaction with DNA Article Swipe
Fahimeh Salehi
,
Hossein Behboudi
,
Gholamreza Kavoosi
,
Sussan K. Ardestani
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-017-02633-z
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-017-02633-z
Recognizing new anticancer compounds to improve Breast cancer treatment seems crucial. Essential oil of Zataria Multiflora (ZEO) is a secondary metabolite with some biological properties, yet underlying cellular and molecular anticancer properties of ZEO is unclear. GC/MS analysis revealed that carvacrol is the major ingredient of the essential oil. ZEO increasingly suppressed viability in MDA-MB-231, MCF-7 and T47D Breast cancer cells while nontoxic to L929 normal cells in monolayer cell cultures (2D), whereas MDA-MB-231 multicellular spheroids (3D) were more resistant to inhibition. ZEO significantly induced cell apoptosis confirmed by fluorescent staining, flow cytometry analysis and DNA fragmentation in MDA-MB-231 2D and 3D cell cultures. ZEO increased ROS generation and subsequent loss of ΔΨm, caspase 3 activation and DNA damage which consequently caused G1 and G2/M cell cycle arrest in a dose- and time-dependent manner in 2D. S phase arrest occurred in cell spheroids therefore ZEO possible DNA interaction with gDNA was investigated and revealed ZEO binds DNA via intercalation. Altogether, these data corroborate anticancer properties of ZEO and suggest that cell culture format (2D monolayer vs. 3D spheroid) plays a critical role in drug response and provides new insights into the mechanisms underlying ZEO cytotoxicity effect on Breast cancer cells.
Related Topics
Concepts
Apoptosis
Chemistry
Cell cycle
Cytotoxicity
Flow cytometry
DNA fragmentation
Cell
DNA
Cell cycle checkpoint
Cell culture
Viability assay
Molecular biology
Cell biology
Programmed cell death
Biochemistry
Biology
In vitro
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-017-02633-z
- https://www.nature.com/articles/s41598-017-02633-z.pdf
- OA Status
- gold
- Cited By
- 42
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2617697375
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2617697375Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-017-02633-zDigital Object Identifier
- Title
-
Monitoring ZEO apoptotic potential in 2D and 3D cell cultures and associated spectroscopic evidence on mode of interaction with DNAWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-05-24Full publication date if available
- Authors
-
Fahimeh Salehi, Hossein Behboudi, Gholamreza Kavoosi, Sussan K. ArdestaniList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-017-02633-zPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-017-02633-z.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41598-017-02633-z.pdfDirect OA link when available
- Concepts
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Apoptosis, Chemistry, Cell cycle, Cytotoxicity, Flow cytometry, DNA fragmentation, Cell, DNA, Cell cycle checkpoint, Cell culture, Viability assay, Molecular biology, Cell biology, Programmed cell death, Biochemistry, Biology, In vitro, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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42Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 8, 2023: 4, 2022: 6, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.activation | 116 |
| abstract_inverted_index.anticancer | 3, 31, 164 |
| abstract_inverted_index.biological | 24 |
| abstract_inverted_index.generation | 108 |
| abstract_inverted_index.ingredient | 45 |
| abstract_inverted_index.mechanisms | 192 |
| abstract_inverted_index.metabolite | 21 |
| abstract_inverted_index.properties | 32, 165 |
| abstract_inverted_index.subsequent | 110 |
| abstract_inverted_index.suppressed | 52 |
| abstract_inverted_index.underlying | 27, 193 |
| abstract_inverted_index.Altogether, | 160 |
| abstract_inverted_index.MDA-MB-231, | 55 |
| abstract_inverted_index.Recognizing | 1 |
| abstract_inverted_index.corroborate | 163 |
| abstract_inverted_index.fluorescent | 90 |
| abstract_inverted_index.inhibition. | 82 |
| abstract_inverted_index.interaction | 148 |
| abstract_inverted_index.properties, | 25 |
| abstract_inverted_index.consequently | 121 |
| abstract_inverted_index.cytotoxicity | 195 |
| abstract_inverted_index.increasingly | 51 |
| abstract_inverted_index.investigated | 152 |
| abstract_inverted_index.fragmentation | 97 |
| abstract_inverted_index.multicellular | 75 |
| abstract_inverted_index.significantly | 84 |
| abstract_inverted_index.intercalation. | 159 |
| abstract_inverted_index.time-dependent | 133 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.94565369 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |