Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal rats Article Swipe
Richa Tiwary
,
John H. Richburg
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/toxsci/kfad116
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/toxsci/kfad116
The blood-testis barrier (BTB) is constituted by tight junctions between adjacent Sertoli cells (SCs) that create a specialized adluminal microenvironment to foster the development of spermatocytes and spermatids. The BTB is a well-studied target of numerous environmental toxicants, including di-(2-ethylhexyl) phthalate (DEHP), a compound widely used in various consumer products. Mono-(2-ethylhexyl) phthalate (MEHP) is the active toxic metabolite of DEHP that has long been recognized in postnatal rodents to disrupt SC function. This study evaluates the impact of MEHP on the integrity of the BTB in both pubertal and adult rats and the signal transduction pathways known to be involved in the disruption of the BTB. Treatment of prepubertal rats with 700 mg/kg MEHP for 24 h functionally disrupted the BTB integrity. A similar treatment of adult rats with MEHP did not disrupt the integrity of the BTB. The observed disruption of the BTB integrity in the MEHP-treated prepubertal rats occurred concomitantly with a decreased expression and mislocalization of both the ZO1 and occludin tight junction-associated proteins, as well as sloughing of spermatocytes and spermatids. At this same time, MEHP treatment induced a transient surge of p44/42 mitogen-activated protein kinase (MAPK) pathway. Interestingly, after a recovery period of 5 weeks, the BTB recovered and was functionally intact. This is the first report to indicate that acute MEHP exposure of prepubertal rats, but not adult rats, disrupts the functional integrity of the BTB and that this effect on the BTB is reversible.
Related Topics
Concepts
Phthalate
Blood–testis barrier
Chemistry
Endocrinology
Internal medicine
Andrology
Sertoli cell
Medicine
Spermatogenesis
Organic chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/toxsci/kfad116
- https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfad116/52952613/kfad116.pdf
- OA Status
- hybrid
- Cited By
- 13
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388532244
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388532244Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/toxsci/kfad116Digital Object Identifier
- Title
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Mono-(2-ethylhexyl) phthalate reversibly disrupts the blood-testis barrier in pubertal ratsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-11-06Full publication date if available
- Authors
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Richa Tiwary, John H. RichburgList of authors in order
- Landing page
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https://doi.org/10.1093/toxsci/kfad116Publisher landing page
- PDF URL
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https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfad116/52952613/kfad116.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfad116/52952613/kfad116.pdfDirect OA link when available
- Concepts
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Phthalate, Blood–testis barrier, Chemistry, Endocrinology, Internal medicine, Andrology, Sertoli cell, Medicine, Spermatogenesis, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
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13Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 6, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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24Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.to | 21, 69, 98, 213 |
| abstract_inverted_index.700 | 112 |
| abstract_inverted_index.BTB | 30, 85, 121, 144, 202, 232, 239 |
| abstract_inverted_index.The | 1, 29, 139 |
| abstract_inverted_index.ZO1 | 162 |
| abstract_inverted_index.and | 27, 89, 92, 157, 163, 174, 204, 233 |
| abstract_inverted_index.but | 222 |
| abstract_inverted_index.did | 131 |
| abstract_inverted_index.for | 115 |
| abstract_inverted_index.has | 62 |
| abstract_inverted_index.not | 132, 223 |
| abstract_inverted_index.the | 23, 55, 76, 81, 84, 93, 102, 105, 120, 134, 137, 143, 147, 161, 201, 210, 227, 231, 238 |
| abstract_inverted_index.was | 205 |
| abstract_inverted_index.BTB. | 106, 138 |
| abstract_inverted_index.DEHP | 60 |
| abstract_inverted_index.MEHP | 79, 114, 130, 180, 217 |
| abstract_inverted_index.This | 73, 208 |
| abstract_inverted_index.been | 64 |
| abstract_inverted_index.both | 87, 160 |
| abstract_inverted_index.long | 63 |
| abstract_inverted_index.rats | 91, 110, 128, 150 |
| abstract_inverted_index.same | 178 |
| abstract_inverted_index.that | 15, 61, 215, 234 |
| abstract_inverted_index.this | 177, 235 |
| abstract_inverted_index.used | 46 |
| abstract_inverted_index.well | 169 |
| abstract_inverted_index.with | 111, 129, 153 |
| abstract_inverted_index.(BTB) | 4 |
| abstract_inverted_index.(SCs) | 14 |
| abstract_inverted_index.acute | 216 |
| abstract_inverted_index.adult | 90, 127, 224 |
| abstract_inverted_index.after | 194 |
| abstract_inverted_index.cells | 13 |
| abstract_inverted_index.first | 211 |
| abstract_inverted_index.known | 97 |
| abstract_inverted_index.mg/kg | 113 |
| abstract_inverted_index.rats, | 221, 225 |
| abstract_inverted_index.study | 74 |
| abstract_inverted_index.surge | 185 |
| abstract_inverted_index.tight | 8, 165 |
| abstract_inverted_index.time, | 179 |
| abstract_inverted_index.toxic | 57 |
| abstract_inverted_index.(MAPK) | 191 |
| abstract_inverted_index.(MEHP) | 53 |
| abstract_inverted_index.active | 56 |
| abstract_inverted_index.create | 16 |
| abstract_inverted_index.effect | 236 |
| abstract_inverted_index.foster | 22 |
| abstract_inverted_index.impact | 77 |
| abstract_inverted_index.kinase | 190 |
| abstract_inverted_index.p44/42 | 187 |
| abstract_inverted_index.period | 197 |
| abstract_inverted_index.report | 212 |
| abstract_inverted_index.signal | 94 |
| abstract_inverted_index.target | 34 |
| abstract_inverted_index.weeks, | 200 |
| abstract_inverted_index.widely | 45 |
| abstract_inverted_index.(DEHP), | 42 |
| abstract_inverted_index.Sertoli | 12 |
| abstract_inverted_index.barrier | 3 |
| abstract_inverted_index.between | 10 |
| abstract_inverted_index.disrupt | 70, 133 |
| abstract_inverted_index.induced | 182 |
| abstract_inverted_index.intact. | 207 |
| abstract_inverted_index.protein | 189 |
| abstract_inverted_index.rodents | 68 |
| abstract_inverted_index.similar | 124 |
| abstract_inverted_index.various | 48 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.adjacent | 11 |
| abstract_inverted_index.compound | 44 |
| abstract_inverted_index.consumer | 49 |
| abstract_inverted_index.disrupts | 226 |
| abstract_inverted_index.exposure | 218 |
| abstract_inverted_index.indicate | 214 |
| abstract_inverted_index.involved | 100 |
| abstract_inverted_index.numerous | 36 |
| abstract_inverted_index.observed | 140 |
| abstract_inverted_index.occludin | 164 |
| abstract_inverted_index.occurred | 151 |
| abstract_inverted_index.pathway. | 192 |
| abstract_inverted_index.pathways | 96 |
| abstract_inverted_index.pubertal | 88 |
| abstract_inverted_index.recovery | 196 |
| abstract_inverted_index.Treatment | 107 |
| abstract_inverted_index.adluminal | 19 |
| abstract_inverted_index.decreased | 155 |
| abstract_inverted_index.disrupted | 119 |
| abstract_inverted_index.evaluates | 75 |
| abstract_inverted_index.function. | 72 |
| abstract_inverted_index.including | 39 |
| abstract_inverted_index.integrity | 82, 135, 145, 229 |
| abstract_inverted_index.junctions | 9 |
| abstract_inverted_index.phthalate | 41, 52 |
| abstract_inverted_index.postnatal | 67 |
| abstract_inverted_index.products. | 50 |
| abstract_inverted_index.proteins, | 167 |
| abstract_inverted_index.recovered | 203 |
| abstract_inverted_index.sloughing | 171 |
| abstract_inverted_index.transient | 184 |
| abstract_inverted_index.treatment | 125, 181 |
| abstract_inverted_index.disruption | 103, 141 |
| abstract_inverted_index.expression | 156 |
| abstract_inverted_index.functional | 228 |
| abstract_inverted_index.integrity. | 122 |
| abstract_inverted_index.metabolite | 58 |
| abstract_inverted_index.recognized | 65 |
| abstract_inverted_index.toxicants, | 38 |
| abstract_inverted_index.constituted | 6 |
| abstract_inverted_index.development | 24 |
| abstract_inverted_index.prepubertal | 109, 149, 220 |
| abstract_inverted_index.reversible. | 241 |
| abstract_inverted_index.specialized | 18 |
| abstract_inverted_index.spermatids. | 28, 175 |
| abstract_inverted_index.MEHP-treated | 148 |
| abstract_inverted_index.blood-testis | 2 |
| abstract_inverted_index.functionally | 118, 206 |
| abstract_inverted_index.transduction | 95 |
| abstract_inverted_index.well-studied | 33 |
| abstract_inverted_index.concomitantly | 152 |
| abstract_inverted_index.environmental | 37 |
| abstract_inverted_index.spermatocytes | 26, 173 |
| abstract_inverted_index.Interestingly, | 193 |
| abstract_inverted_index.mislocalization | 158 |
| abstract_inverted_index.microenvironment | 20 |
| abstract_inverted_index.di-(2-ethylhexyl) | 40 |
| abstract_inverted_index.mitogen-activated | 188 |
| abstract_inverted_index.Mono-(2-ethylhexyl) | 51 |
| abstract_inverted_index.junction-associated | 166 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 2 |
| citation_normalized_percentile.value | 0.88133801 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |