Monocyte Dynamics in Chikungunya Fever: Sustained Activation and Vascular-Coagulation Pathway Involvement Article Swipe
Caroline Fernandes-Santos
,
Priscila Conrado Guerra Nunes
,
Víctor Fiestas Solórzano
,
Mariana Gandini
,
Flávia Barreto dos Santos
,
Roberta Olmo Pinheiro
,
L. C. B. Souza
,
Paulo Vieira Damasco
,
Luzia Maria de Oliveira Pinto
,
Elzinandes Leal de Azeredo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/v17091224
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/v17091224
Chikungunya fever (CF), caused by the Chikungunya virus (CHIKV), is characterized by disabling symptoms such as joint pain that can last for months. Monocytes play a central role in immune modulation and viral replication during infection. This study evaluated the clinical and immunological profiles of patients with laboratory-confirmed CF. Fever and joint pain were the most frequently reported symptoms, whereas edema was more common in women. CHIKV-infect individuals exhibited increased TLR4 expression in non-classical monocytes (CD14+CD16++). Additionally, intermediate (CD14+CD16+) and non-classical (CD14+CD16++) monocytes expressing TLR7 were enriched during the acute phase and in some chronic patients, thereby suggest prolonged TLR7 pathway activation. Levels of soluble CD163 (sCD163)—a marker of monocyte/macrophage activation—were elevated as well, indicating sustained immune activation. Coagulation-related mediators—including Tissue factor (TF) and Tissue factor pathway inhibitor (TFPI)—also increased, despite the rarity of hemorrhagic events or thrombocytopenia. Patients with arthritis demonstrated higher frequencies of TLR7+ intermediate monocytes and elevated Epidermal growth factor (EGF) levels, whereas those with edema exhibit increased Vascular endothelial growth factor (VEGF) levels. Overall, these findings highlighted the differential activation of CD16+ monocytes and suggested that sCD163 is a marker of monocyte/macrophage activation during CHIKV infection.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v17091224
- https://www.mdpi.com/1999-4915/17/9/1224/pdf?version=1757300426
- OA Status
- gold
- References
- 87
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4414070322
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4414070322Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/v17091224Digital Object Identifier
- Title
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Monocyte Dynamics in Chikungunya Fever: Sustained Activation and Vascular-Coagulation Pathway InvolvementWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-09-07Full publication date if available
- Authors
-
Caroline Fernandes-Santos, Priscila Conrado Guerra Nunes, Víctor Fiestas Solórzano, Mariana Gandini, Flávia Barreto dos Santos, Roberta Olmo Pinheiro, L. C. B. Souza, Paulo Vieira Damasco, Luzia Maria de Oliveira Pinto, Elzinandes Leal de AzeredoList of authors in order
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https://doi.org/10.3390/v17091224Publisher landing page
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https://www.mdpi.com/1999-4915/17/9/1224/pdf?version=1757300426Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1999-4915/17/9/1224/pdf?version=1757300426Direct OA link when available
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0Total citation count in OpenAlex
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87Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.frequencies | 143 |
| abstract_inverted_index.hemorrhagic | 134 |
| abstract_inverted_index.highlighted | 170 |
| abstract_inverted_index.individuals | 67 |
| abstract_inverted_index.replication | 33 |
| abstract_inverted_index.(CD14+CD16+) | 78 |
| abstract_inverted_index.(sCD163)—a | 106 |
| abstract_inverted_index.CHIKV-infect | 66 |
| abstract_inverted_index.demonstrated | 141 |
| abstract_inverted_index.differential | 172 |
| abstract_inverted_index.intermediate | 77, 146 |
| abstract_inverted_index.(CD14+CD16++) | 81 |
| abstract_inverted_index.(TFPI)—also | 128 |
| abstract_inverted_index.Additionally, | 76 |
| abstract_inverted_index.characterized | 10 |
| abstract_inverted_index.immunological | 42 |
| abstract_inverted_index.non-classical | 73, 80 |
| abstract_inverted_index.(CD14+CD16++). | 75 |
| abstract_inverted_index.activation—were | 110 |
| abstract_inverted_index.thrombocytopenia. | 137 |
| abstract_inverted_index.Coagulation-related | 118 |
| abstract_inverted_index.monocyte/macrophage | 109, 185 |
| abstract_inverted_index.laboratory-confirmed | 47 |
| abstract_inverted_index.mediators—including | 119 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5108247789 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I52325 |
| citation_normalized_percentile.value | 0.50179065 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |