Monosynaptic Tracing Success Depends Critically on Helper Virus Concentrations Article Swipe
Thomas K. Lavin
,
Lei Jin
,
Nicholas E. Lea
,
Ian R. Wickersham
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fnsyn.2020.00006
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fnsyn.2020.00006
Monosynaptically-restricted transsynaptic tracing using deletion-mutant rabies virus (RV) has become a widely used technique in neuroscience, allowing identification, imaging, and manipulation of neurons directly presynaptic to a starting neuronal population. Its most common implementation is to use Cre mouse lines in combination with Cre-dependent "helper" adeno-associated viral vectors (AAVs) to supply the required genes to the targeted population before subsequent injection of a first-generation (ΔG) rabies viral vector. Here we show that the efficiency of transsynaptic spread and the degree of nonspecific labeling in wild-type control animals depend strongly on the concentrations of these helper AAVs. Our results suggest practical guidelines for achieving good results.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnsyn.2020.00006
- OA Status
- gold
- Cited By
- 71
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3006083829
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3006083829Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnsyn.2020.00006Digital Object Identifier
- Title
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Monosynaptic Tracing Success Depends Critically on Helper Virus ConcentrationsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-02-14Full publication date if available
- Authors
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Thomas K. Lavin, Lei Jin, Nicholas E. Lea, Ian R. WickershamList of authors in order
- Landing page
-
https://doi.org/10.3389/fnsyn.2020.00006Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fnsyn.2020.00006Direct OA link when available
- Concepts
-
Neuroscience, Rabies virus, Population, Rabies, Biology, Virus, Viral vector, Virology, Medicine, Gene, Genetics, Environmental health, Recombinant DNATop concepts (fields/topics) attached by OpenAlex
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71Total citation count in OpenAlex
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2025: 9, 2024: 12, 2023: 19, 2022: 12, 2021: 8Per-year citation counts (last 5 years)
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60Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| primary_location.raw_type | journal-article |
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| primary_location.is_accepted | True |
| primary_location.is_published | True |
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| publication_date | 2020-02-14 |
| publication_year | 2020 |
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| abstract_inverted_index.is | 34 |
| abstract_inverted_index.of | 21, 61, 74, 80, 92 |
| abstract_inverted_index.on | 89 |
| abstract_inverted_index.to | 25, 35, 49, 54 |
| abstract_inverted_index.we | 69 |
| abstract_inverted_index.Cre | 37 |
| abstract_inverted_index.Its | 30 |
| abstract_inverted_index.Our | 96 |
| abstract_inverted_index.and | 19, 77 |
| abstract_inverted_index.for | 101 |
| abstract_inverted_index.has | 8 |
| abstract_inverted_index.the | 51, 55, 72, 78, 90 |
| abstract_inverted_index.use | 36 |
| abstract_inverted_index.(RV) | 7 |
| abstract_inverted_index.Here | 68 |
| abstract_inverted_index.good | 103 |
| abstract_inverted_index.most | 31 |
| abstract_inverted_index.show | 70 |
| abstract_inverted_index.that | 71 |
| abstract_inverted_index.used | 12 |
| abstract_inverted_index.with | 42 |
| abstract_inverted_index.(ΔG) | 64 |
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| abstract_inverted_index.genes | 53 |
| abstract_inverted_index.lines | 39 |
| abstract_inverted_index.mouse | 38 |
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| abstract_inverted_index.viral | 46, 66 |
| abstract_inverted_index.virus | 6 |
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