Monoterpene indole alkaloids with anticancer activity from Tabernaemontana species Article Swipe
Bruno M. F. Gonçalves
,
Noélia Duarte
,
Cátia Ramalhete
,
Filipa Barbosa
,
AM Madureira
,
Maria‐José U. Ferreira
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s11101-024-09964-6
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s11101-024-09964-6
Indole alkaloids, predominantly found in plants, are a large group of natural product-derived compounds characterized by a remarkable chemical diversity associated with significant biological properties. Among these, terpenoid indole alkaloids are the largest group of secondary metabolites. Tabernaemontana species (Apocynaceae) are widely distributed in tropical and subtropical regions of the world and used in traditional medicine to treat a variety of illnesses, including tumours. These species biosynthesize large quantities of structurally complex monoterpene indole and bisindole alkaloids. Given the compelling biological properties of indole alkaloids, the phytochemical study of Tabernaemontana species has been widely addressed to identify potential anticancer compounds. Several indole alkaloids have shown antiproliferative effect due to different mechanisms, namely by inducing apoptosis or arresting cell cycle, in diverse cancer cell lines, including multidrug-resistant phenotypes. This review primarily aims to underscore the anticancer activity of indole and bisindole alkaloids isolated from several Tabernaemontana species. Moreover, our recent contributions to the field are also highlighted, focusing on the study of Tabernaemontana elegans . The anticancer evaluation, namely the reversion of P-glycoprotein-mediated multidrug resistance, of two sets of monoterpene indole alkaloid derivatives, obtained by modification of some functional groups of two major monoterpene indole alkaloids, is reviewed, as well as the results obtained for a derivative that targeted homologous recombination DNA repair defects.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s11101-024-09964-6
- https://link.springer.com/content/pdf/10.1007/s11101-024-09964-6.pdf
- OA Status
- hybrid
- Cited By
- 12
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4395694833Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s11101-024-09964-6Digital Object Identifier
- Title
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Monoterpene indole alkaloids with anticancer activity from Tabernaemontana speciesWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2024Year of publication
- Publication date
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2024-04-27Full publication date if available
- Authors
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Bruno M. F. Gonçalves, Noélia Duarte, Cátia Ramalhete, Filipa Barbosa, AM Madureira, Maria‐José U. FerreiraList of authors in order
- Landing page
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https://doi.org/10.1007/s11101-024-09964-6Publisher landing page
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https://link.springer.com/content/pdf/10.1007/s11101-024-09964-6.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s11101-024-09964-6.pdfDirect OA link when available
- Concepts
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Indole test, Monoterpene, Apocynaceae, Stereochemistry, Botany, Biology, Alkaloid, Traditional medicine, Indole alkaloid, Chemistry, MedicineTop concepts (fields/topics) attached by OpenAlex
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12Total citation count in OpenAlex
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2025: 6, 2024: 6Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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