Mood After Parathyroidectomy in Primary Hyperparathyroidism. A Systematic Review and Meta-Analysis Article Swipe
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/bjs/znaf096.009
· OA: W4410480004
Background Most patients with primary hyperparathyroidism (PHPT) are diagnosed incidentally through routine tests. Patients may present depressive symptoms and mood disturbances that may affect their quality of life. The objective of this study was to analyse the published articles that evaluate the analysis of the mood of patients with PHPT and the changes produced in the short, mid and long term after parathyroidectomy. Methods A systematic review of the literature on published articles that evaluated the role of parathyroidectomy on symptoms related to depression in PHPT was carried out. The selection of studies was guided by the PRISMA strategy. A meta-analysis was performed with studies that used the two most common mood-specific questionnaires. Results 20 studies conducted in 9 different countries were included. A total PHPT patient population of 1885 cases were assembled and 9 specific measuring instruments for mood were used. The meta-analysis revealed a significant short-term improvement in depression scores after surgery (effect estimate = 0.57; 95% CI: 0.33 to 0.81), though with notable heterogeneity among studies. Mid-term assessments did not show consistent evidence of improvement (effect estimate = 0.68; 95% CI: -0.32 to 1.69). However, long-term analysis demonstrated a significant and consistent reduction in depression scores (effect estimate = 0.46; 95% CI: 0.21 to 0.71) across studies. Conclusion Patients with PHPT often present with depressive symptoms at diagnosis. Following parathyroidectomy, a significant improvement in these symptoms is observed. The meta-analysis confirms marked reductions in depression scores shortly after surgery, with these benefits sustained over the long term.
