Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes Article Swipe
Alparslan Asan
,
Stephan Raiders
,
James R Priess
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pgen.1005950
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pgen.1005950
Genetic and molecular studies have provided considerable insight into how various tissue progenitors are specified in early embryogenesis, but much less is known about how those progenitors create three-dimensional tissues and organs. The C. elegans intestine provides a simple system for studying how a single progenitor, the E blastomere, builds an epithelial tube of 20 cells. As the E descendants divide, they form a primordium that transitions between different shapes over time. We used cell contours, traced from confocal optical z-stacks, to build a 3D graphic reconstruction of intestine development. The reconstruction revealed several new aspects of morphogenesis that extend and clarify previous observations. The first 8 E descendants form a plane of four right cells and four left cells; the plane arises through oriented cell divisions and VANG-1/Van Gogh-dependent repositioning of any non-planar cells. LIN-12/Notch signaling affects the left cells in the E8 primordium, and initiates later asymmetry in cell packing. The next few stages involve cell repositioning and intercalation events that shuttle cells to their final positions, like shifting blocks in a Rubik's cube. Repositioning involves breaking and replacing specific adhesive contacts, and some of these events involve EFN-4/Ephrin, MAB-20/semaphorin-2a, and SAX-3/Robo. Once cells in the primordium align along a common axis and in the correct order, cells at the anterior end rotate clockwise around the axis of the intestine. The anterior rotation appears to align segments of the developing lumen into a continuous structure, and requires the secreted ligand UNC-6/netrin, the receptor UNC-40/DCC, and an interacting protein called MADD-2. Previous studies showed that rotation requires a second round of LIN-12/Notch signaling in cells on the right side of the primordium, and we show that MADD-2-GFP appears to be downregulated in those cells.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pgen.1005950
- https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005950&type=printable
- OA Status
- gold
- Cited By
- 45
- References
- 91
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2334919903
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2334919903Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pgen.1005950Digital Object Identifier
- Title
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Morphogenesis of the C. elegans Intestine Involves Axon Guidance GenesWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-04-01Full publication date if available
- Authors
-
Alparslan Asan, Stephan Raiders, James R PriessList of authors in order
- Landing page
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https://doi.org/10.1371/journal.pgen.1005950Publisher landing page
- PDF URL
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005950&type=printableDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005950&type=printableDirect OA link when available
- Concepts
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Biology, Primordium, Morphogenesis, Cell biology, Progenitor cell, Anatomy, Stem cell, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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45Total citation count in OpenAlex
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2025: 1, 2024: 5, 2023: 10, 2022: 4, 2021: 5Per-year citation counts (last 5 years)
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91Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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