Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options Article Swipe
Robert Brown
,
Syed Naqvi
,
Mary F. McGuire
,
Jamie Buryanek
,
Ron J. Karni
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1186/s40463-017-0230-2
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1186/s40463-017-0230-2
Background Human papillomavirus (HPV) has been identified as an etiopathogenetic factor in oropharyngeal squamous cell carcinoma. The HPV E6 and E7 oncogenes are instrumental in promoting proliferation and blocking differentiation leading to tumorigenesis. Although surgical intervention can remove such tumors, the potential for an etiologic field effect with recurrent disease is real. A downstream effector of E7 oncoprotein, enhancer of zeste homolog 2 (EZH2), is known to promote proliferation and to pose a block in differentiation and in turn, could lead to HPV-induced malignant transformation. However, the EZH2 pathway is amenable to low toxicity therapies designed to promote differentiation to a more benign state and prevent recurrent disease by inhibiting the incorporation of HPV into the genome. This is the first study using clinical specimens to demonstrate EZH2 protein expression in oropharyngeal carcinoma (OPC). Methods The study included eight patients with oropharyngeal carcinoma, confirmed p16INK4a- positive by immunohistochemistry (IHC). The tissue expression of E6/E7 messenger RNA (mRNA) was measured by RNAscope® in-situ hybridization technology. Expression of EZH2, Ki-67, and mitotic indices were assessed by morphoproteomic analysis. Biomedical analytics expanded the results with data from Ingenuity Pathway Analysis (IPA) and KEGG databases to construct a molecular network pathway for further insights. Results Expression of E6 and E7 oncogenes in p16INK4a- positive oropharyngeal carcinoma was confirmed. EZH2 and its correlates, including elevated proliferation index (Ki-67) and mitotic progression were also present. Biomedical analytics validated the relationship between HPV- E6 and E7 and the expression of the EZH2 pathway. Conclusion There is morphoproteomic and mRNA evidence of the association of p16INK4a-HPV infection with the E6 and E7 oncogenes and the expression of EZH2, Ki-67 and mitotic progression in oropharyngeal carcinoma. The molecular network biology was confirmed by biomedical analytics as consistent with published literature. This is significant because the biology lends itself to targeted therapeutic options using metformin, curcumin, celecoxib and sulforaphane as therapeutic strategies to prevent progression or recurrence of disease.
Related Topics
Concepts
In situ
In situ hybridization
Medicine
Carcinoma in situ
Computational biology
Pathology
Biology
Carcinoma
Chemistry
Genetics
Gene
Gene expression
Organic chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s40463-017-0230-2
- https://journalotohns.biomedcentral.com/counter/pdf/10.1186/s40463-017-0230-2
- OA Status
- gold
- Cited By
- 3
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2749558575
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2749558575Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s40463-017-0230-2Digital Object Identifier
- Title
-
Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic optionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-01-01Full publication date if available
- Authors
-
Robert Brown, Syed Naqvi, Mary F. McGuire, Jamie Buryanek, Ron J. KarniList of authors in order
- Landing page
-
https://doi.org/10.1186/s40463-017-0230-2Publisher landing page
- PDF URL
-
https://journalotohns.biomedcentral.com/counter/pdf/10.1186/s40463-017-0230-2Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journalotohns.biomedcentral.com/counter/pdf/10.1186/s40463-017-0230-2Direct OA link when available
- Concepts
-
In situ, In situ hybridization, Medicine, Carcinoma in situ, Computational biology, Pathology, Biology, Carcinoma, Chemistry, Genetics, Gene, Gene expression, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1, 2020: 1, 2018: 1Per-year citation counts (last 5 years)
- References (count)
-
26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2749558575 |
|---|---|
| doi | https://doi.org/10.1186/s40463-017-0230-2 |
| ids.doi | https://doi.org/10.1186/s40463-017-0230-2 |
| ids.mag | 2749558575 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/28818106 |
| ids.openalex | https://openalex.org/W2749558575 |
| fwci | 0.4924957 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000368 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Aged |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D001707 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Biopsy, Needle |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D000071221 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Enhancer of Zeste Homolog 2 Protein |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D005260 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Female |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D015972 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Gene Expression Regulation, Neoplastic |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D006801 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Humans |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D007150 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Immunohistochemistry |
| mesh[7].qualifier_ui | Q000379 |
| mesh[7].descriptor_ui | D017403 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | methods |
| mesh[7].descriptor_name | In Situ Hybridization |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D008297 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Male |
| mesh[9].qualifier_ui | Q000379 |
| mesh[9].descriptor_ui | D058990 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | methods |
| mesh[9].descriptor_name | Molecular Targeted Therapy |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D009856 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Oncogene Proteins, Viral |
| mesh[11].qualifier_ui | Q000188 |
| mesh[11].descriptor_ui | D009959 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | drug therapy |
| mesh[11].descriptor_name | Oropharyngeal Neoplasms |
| mesh[12].qualifier_ui | Q000473 |
| mesh[12].descriptor_ui | D009959 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | pathology |
| mesh[12].descriptor_name | Oropharyngeal Neoplasms |
| mesh[13].qualifier_ui | Q000821 |
| mesh[13].descriptor_ui | D009959 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | virology |
| mesh[13].descriptor_name | Oropharyngeal Neoplasms |
| mesh[14].qualifier_ui | Q000235 |
| mesh[14].descriptor_ui | D027383 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | genetics |
| mesh[14].descriptor_name | Papillomaviridae |
| mesh[15].qualifier_ui | Q000472 |
| mesh[15].descriptor_ui | D027383 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pathogenicity |
| mesh[15].descriptor_name | Papillomaviridae |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D050725 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | Papillomavirus E7 Proteins |
| mesh[17].qualifier_ui | Q000188 |
| mesh[17].descriptor_ui | D030361 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | drug therapy |
| mesh[17].descriptor_name | Papillomavirus Infections |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D030361 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Papillomavirus Infections |
| mesh[19].qualifier_ui | Q000473 |
| mesh[19].descriptor_ui | D030361 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | pathology |
| mesh[19].descriptor_name | Papillomavirus Infections |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D011379 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Prognosis |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D040901 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Proteomics |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D012333 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | RNA, Messenger |
| mesh[23].qualifier_ui | Q000235 |
| mesh[23].descriptor_ui | D012097 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | genetics |
| mesh[23].descriptor_name | Repressor Proteins |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D012494 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Sampling Studies |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D016896 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Treatment Outcome |
| mesh[26].qualifier_ui | Q000188 |
| mesh[26].descriptor_ui | D014412 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | drug therapy |
| mesh[26].descriptor_name | Tumor Virus Infections |
| mesh[27].qualifier_ui | Q000235 |
| mesh[27].descriptor_ui | D014412 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | genetics |
| mesh[27].descriptor_name | Tumor Virus Infections |
| mesh[28].qualifier_ui | Q000473 |
| mesh[28].descriptor_ui | D014412 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | pathology |
| mesh[28].descriptor_name | Tumor Virus Infections |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D000368 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Aged |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D001707 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Biopsy, Needle |
| mesh[31].qualifier_ui | Q000235 |
| mesh[31].descriptor_ui | D000071221 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | genetics |
| mesh[31].descriptor_name | Enhancer of Zeste Homolog 2 Protein |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D005260 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Female |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D015972 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Gene Expression Regulation, Neoplastic |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D006801 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Humans |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D007150 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Immunohistochemistry |
| mesh[36].qualifier_ui | Q000379 |
| mesh[36].descriptor_ui | D017403 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | methods |
| mesh[36].descriptor_name | In Situ Hybridization |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D008297 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Male |
| mesh[38].qualifier_ui | Q000379 |
| mesh[38].descriptor_ui | D058990 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | methods |
| mesh[38].descriptor_name | Molecular Targeted Therapy |
| mesh[39].qualifier_ui | Q000235 |
| mesh[39].descriptor_ui | D009856 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | genetics |
| mesh[39].descriptor_name | Oncogene Proteins, Viral |
| mesh[40].qualifier_ui | Q000188 |
| mesh[40].descriptor_ui | D009959 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | drug therapy |
| mesh[40].descriptor_name | Oropharyngeal Neoplasms |
| mesh[41].qualifier_ui | Q000473 |
| mesh[41].descriptor_ui | D009959 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | pathology |
| mesh[41].descriptor_name | Oropharyngeal Neoplasms |
| mesh[42].qualifier_ui | Q000821 |
| mesh[42].descriptor_ui | D009959 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | virology |
| mesh[42].descriptor_name | Oropharyngeal Neoplasms |
| mesh[43].qualifier_ui | Q000235 |
| mesh[43].descriptor_ui | D027383 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | genetics |
| mesh[43].descriptor_name | Papillomaviridae |
| mesh[44].qualifier_ui | Q000472 |
| mesh[44].descriptor_ui | D027383 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | pathogenicity |
| mesh[44].descriptor_name | Papillomaviridae |
| mesh[45].qualifier_ui | Q000235 |
| mesh[45].descriptor_ui | D050725 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | genetics |
| mesh[45].descriptor_name | Papillomavirus E7 Proteins |
| mesh[46].qualifier_ui | Q000188 |
| mesh[46].descriptor_ui | D030361 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | drug therapy |
| mesh[46].descriptor_name | Papillomavirus Infections |
| mesh[47].qualifier_ui | Q000235 |
| mesh[47].descriptor_ui | D030361 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | genetics |
| mesh[47].descriptor_name | Papillomavirus Infections |
| mesh[48].qualifier_ui | Q000473 |
| mesh[48].descriptor_ui | D030361 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | pathology |
| mesh[48].descriptor_name | Papillomavirus Infections |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D011379 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Prognosis |
| type | article |
| title | Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options |
| biblio.issue | 1 |
| biblio.volume | 46 |
| biblio.last_page | 52 |
| biblio.first_page | 52 |
| topics[0].id | https://openalex.org/T10307 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9994000196456909 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2733 |
| topics[0].subfield.display_name | Otorhinolaryngology |
| topics[0].display_name | Head and Neck Cancer Studies |
| topics[1].id | https://openalex.org/T10146 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9912999868392944 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2713 |
| topics[1].subfield.display_name | Epidemiology |
| topics[1].display_name | Cervical Cancer and HPV Research |
| topics[2].id | https://openalex.org/T12422 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9879000186920166 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2741 |
| topics[2].subfield.display_name | Radiology, Nuclear Medicine and Imaging |
| topics[2].display_name | Radiomics and Machine Learning in Medical Imaging |
| is_xpac | False |
| apc_list.value | 1790 |
| apc_list.currency | GBP |
| apc_list.value_usd | 2195 |
| apc_paid.value | 1790 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 2195 |
| concepts[0].id | https://openalex.org/C2777822432 |
| concepts[0].level | 2 |
| concepts[0].score | 0.5884730219841003 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q216681 |
| concepts[0].display_name | In situ |
| concepts[1].id | https://openalex.org/C81439078 |
| concepts[1].level | 4 |
| concepts[1].score | 0.5630335807800293 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q2304142 |
| concepts[1].display_name | In situ hybridization |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.45801323652267456 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C2777661416 |
| concepts[3].level | 3 |
| concepts[3].score | 0.41980358958244324 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1035645 |
| concepts[3].display_name | Carcinoma in situ |
| concepts[4].id | https://openalex.org/C70721500 |
| concepts[4].level | 1 |
| concepts[4].score | 0.34092843532562256 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[4].display_name | Computational biology |
| concepts[5].id | https://openalex.org/C142724271 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3168868124485016 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[5].display_name | Pathology |
| concepts[6].id | https://openalex.org/C86803240 |
| concepts[6].level | 0 |
| concepts[6].score | 0.2725582420825958 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[6].display_name | Biology |
| concepts[7].id | https://openalex.org/C2777546739 |
| concepts[7].level | 2 |
| concepts[7].score | 0.22016015648841858 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q33525 |
| concepts[7].display_name | Carcinoma |
| concepts[8].id | https://openalex.org/C185592680 |
| concepts[8].level | 0 |
| concepts[8].score | 0.19788292050361633 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[8].display_name | Chemistry |
| concepts[9].id | https://openalex.org/C54355233 |
| concepts[9].level | 1 |
| concepts[9].score | 0.08289924263954163 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[9].display_name | Genetics |
| concepts[10].id | https://openalex.org/C104317684 |
| concepts[10].level | 2 |
| concepts[10].score | 0.06723380088806152 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[10].display_name | Gene |
| concepts[11].id | https://openalex.org/C150194340 |
| concepts[11].level | 3 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[11].display_name | Gene expression |
| concepts[12].id | https://openalex.org/C178790620 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[12].display_name | Organic chemistry |
| keywords[0].id | https://openalex.org/keywords/in-situ |
| keywords[0].score | 0.5884730219841003 |
| keywords[0].display_name | In situ |
| keywords[1].id | https://openalex.org/keywords/in-situ-hybridization |
| keywords[1].score | 0.5630335807800293 |
| keywords[1].display_name | In situ hybridization |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.45801323652267456 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/carcinoma-in-situ |
| keywords[3].score | 0.41980358958244324 |
| keywords[3].display_name | Carcinoma in situ |
| keywords[4].id | https://openalex.org/keywords/computational-biology |
| keywords[4].score | 0.34092843532562256 |
| keywords[4].display_name | Computational biology |
| keywords[5].id | https://openalex.org/keywords/pathology |
| keywords[5].score | 0.3168868124485016 |
| keywords[5].display_name | Pathology |
| keywords[6].id | https://openalex.org/keywords/biology |
| keywords[6].score | 0.2725582420825958 |
| keywords[6].display_name | Biology |
| keywords[7].id | https://openalex.org/keywords/carcinoma |
| keywords[7].score | 0.22016015648841858 |
| keywords[7].display_name | Carcinoma |
| keywords[8].id | https://openalex.org/keywords/chemistry |
| keywords[8].score | 0.19788292050361633 |
| keywords[8].display_name | Chemistry |
| keywords[9].id | https://openalex.org/keywords/genetics |
| keywords[9].score | 0.08289924263954163 |
| keywords[9].display_name | Genetics |
| keywords[10].id | https://openalex.org/keywords/gene |
| keywords[10].score | 0.06723380088806152 |
| keywords[10].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1186/s40463-017-0230-2 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210233012 |
| locations[0].source.issn | 1916-0208, 1916-0216 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1916-0208 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Journal of Otolaryngology - Head and Neck Surgery |
| locations[0].source.host_organization | https://openalex.org/P4310320256 |
| locations[0].source.host_organization_name | BioMed Central |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320256, https://openalex.org/P4310319965 |
| locations[0].source.host_organization_lineage_names | BioMed Central, Springer Nature |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://journalotohns.biomedcentral.com/counter/pdf/10.1186/s40463-017-0230-2 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Otolaryngology - Head & Neck Surgery |
| locations[0].landing_page_url | https://doi.org/10.1186/s40463-017-0230-2 |
| locations[1].id | pmid:28818106 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/28818106 |
| locations[2].id | pmh:oai:doaj.org/article:c40aa3488394433c87e8fb56484af030 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Journal of Otolaryngology - Head and Neck Surgery, Vol 46, Iss 1, Pp 1-8 (2017) |
| locations[2].landing_page_url | https://doaj.org/article/c40aa3488394433c87e8fb56484af030 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:5561614 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://doi.org/10.1186/s40463-017-0230-2 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5053758493 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7960-5755 |
| authorships[0].author.display_name | Robert Brown |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I919571938 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pathology and Laboratory Medicine, at UT Health McGovern Medical School, Houston, TX, USA |
| authorships[0].institutions[0].id | https://openalex.org/I919571938 |
| authorships[0].institutions[0].ror | https://ror.org/03gds6c39 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I919571938 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | The University of Texas Health Science Center at Houston |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Robert E. Brown |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Pathology and Laboratory Medicine, at UT Health McGovern Medical School, Houston, TX, USA |
| authorships[1].author.id | https://openalex.org/A5083765010 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6422-4789 |
| authorships[1].author.display_name | Syed Naqvi |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I919571938 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Otorhinolaryngology, Head and Neck Surgery at UT Health McGovern Medical School, Houston, TX, USA |
| authorships[1].institutions[0].id | https://openalex.org/I919571938 |
| authorships[1].institutions[0].ror | https://ror.org/03gds6c39 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I919571938 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | The University of Texas Health Science Center at Houston |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Syed Naqvi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Otorhinolaryngology, Head and Neck Surgery at UT Health McGovern Medical School, Houston, TX, USA |
| authorships[2].author.id | https://openalex.org/A5043431310 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-4028-8112 |
| authorships[2].author.display_name | Mary F. McGuire |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I919571938 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Pathology and Laboratory Medicine, at UT Health McGovern Medical School, Houston, TX, USA |
| authorships[2].institutions[0].id | https://openalex.org/I919571938 |
| authorships[2].institutions[0].ror | https://ror.org/03gds6c39 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I919571938 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | The University of Texas Health Science Center at Houston |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Mary F. McGuire |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Pathology and Laboratory Medicine, at UT Health McGovern Medical School, Houston, TX, USA |
| authorships[3].author.id | https://openalex.org/A5062416149 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Jamie Buryanek |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I919571938 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pathology and Laboratory Medicine, at UT Health McGovern Medical School, Houston, TX, USA |
| authorships[3].institutions[0].id | https://openalex.org/I919571938 |
| authorships[3].institutions[0].ror | https://ror.org/03gds6c39 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I919571938 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | The University of Texas Health Science Center at Houston |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jamie Buryanek |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pathology and Laboratory Medicine, at UT Health McGovern Medical School, Houston, TX, USA |
| authorships[4].author.id | https://openalex.org/A5090457766 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Ron J. Karni |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I919571938 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Otorhinolaryngology, Head and Neck Surgery at UT Health McGovern Medical School, Houston, TX, USA |
| authorships[4].institutions[0].id | https://openalex.org/I919571938 |
| authorships[4].institutions[0].ror | https://ror.org/03gds6c39 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I919571938 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | The University of Texas Health Science Center at Houston |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Ron J. Karni |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Otorhinolaryngology, Head and Neck Surgery at UT Health McGovern Medical School, Houston, TX, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://journalotohns.biomedcentral.com/counter/pdf/10.1186/s40463-017-0230-2 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Morphoproteomics, E6/E7 in-situ hybridization, and biomedical analytics define the etiopathogenesis of HPV-associated oropharyngeal carcinoma and provide targeted therapeutic options |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10307 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9994000196456909 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2733 |
| primary_topic.subfield.display_name | Otorhinolaryngology |
| primary_topic.display_name | Head and Neck Cancer Studies |
| related_works | https://openalex.org/W1431904956, https://openalex.org/W328764549, https://openalex.org/W590131598, https://openalex.org/W631212016, https://openalex.org/W205374887, https://openalex.org/W2084035151, https://openalex.org/W101045652, https://openalex.org/W1974583777, https://openalex.org/W3085510013, https://openalex.org/W2269144480 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2023 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2020 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2018 |
| counts_by_year[2].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1186/s40463-017-0230-2 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210233012 |
| best_oa_location.source.issn | 1916-0208, 1916-0216 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1916-0208 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Journal of Otolaryngology - Head and Neck Surgery |
| best_oa_location.source.host_organization | https://openalex.org/P4310320256 |
| best_oa_location.source.host_organization_name | BioMed Central |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320256, https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_lineage_names | BioMed Central, Springer Nature |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://journalotohns.biomedcentral.com/counter/pdf/10.1186/s40463-017-0230-2 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Otolaryngology - Head & Neck Surgery |
| best_oa_location.landing_page_url | https://doi.org/10.1186/s40463-017-0230-2 |
| primary_location.id | doi:10.1186/s40463-017-0230-2 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210233012 |
| primary_location.source.issn | 1916-0208, 1916-0216 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1916-0208 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Journal of Otolaryngology - Head and Neck Surgery |
| primary_location.source.host_organization | https://openalex.org/P4310320256 |
| primary_location.source.host_organization_name | BioMed Central |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320256, https://openalex.org/P4310319965 |
| primary_location.source.host_organization_lineage_names | BioMed Central, Springer Nature |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://journalotohns.biomedcentral.com/counter/pdf/10.1186/s40463-017-0230-2 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Otolaryngology - Head & Neck Surgery |
| primary_location.landing_page_url | https://doi.org/10.1186/s40463-017-0230-2 |
| publication_date | 2017-01-01 |
| publication_year | 2017 |
| referenced_works | https://openalex.org/W2494184365, https://openalex.org/W2110664940, https://openalex.org/W2176667622, https://openalex.org/W2018963502, https://openalex.org/W1488538842, https://openalex.org/W1988183415, https://openalex.org/W4247158112, https://openalex.org/W2039382131, https://openalex.org/W2024655023, https://openalex.org/W2055376801, https://openalex.org/W2059058989, https://openalex.org/W1974591990, https://openalex.org/W2080550392, https://openalex.org/W2115105515, https://openalex.org/W1917706778, https://openalex.org/W2050850788, https://openalex.org/W2544813117, https://openalex.org/W2152561870, https://openalex.org/W2168584828, https://openalex.org/W2283275285, https://openalex.org/W2157926595, https://openalex.org/W1967600468, https://openalex.org/W2109545571, https://openalex.org/W2101176115, https://openalex.org/W2585116742, https://openalex.org/W2170682398 |
| referenced_works_count | 26 |
| abstract_inverted_index.2 | 62 |
| abstract_inverted_index.A | 52 |
| abstract_inverted_index.a | 72, 100, 193 |
| abstract_inverted_index.E6 | 18, 203, 236, 261 |
| abstract_inverted_index.E7 | 20, 56, 205, 238, 263 |
| abstract_inverted_index.an | 8, 43 |
| abstract_inverted_index.as | 7, 286, 309 |
| abstract_inverted_index.by | 108, 146, 159, 173, 283 |
| abstract_inverted_index.in | 11, 24, 74, 77, 130, 207, 274 |
| abstract_inverted_index.is | 50, 64, 89, 118, 248, 292 |
| abstract_inverted_index.of | 55, 59, 112, 152, 165, 202, 242, 253, 256, 268, 317 |
| abstract_inverted_index.or | 315 |
| abstract_inverted_index.to | 31, 66, 70, 81, 91, 96, 99, 125, 191, 299, 312 |
| abstract_inverted_index.HPV | 17, 113 |
| abstract_inverted_index.RNA | 155 |
| abstract_inverted_index.The | 16, 135, 149, 277 |
| abstract_inverted_index.and | 19, 27, 69, 76, 104, 168, 188, 204, 215, 223, 237, 239, 250, 262, 265, 271, 307 |
| abstract_inverted_index.are | 22 |
| abstract_inverted_index.can | 36 |
| abstract_inverted_index.for | 42, 197 |
| abstract_inverted_index.has | 4 |
| abstract_inverted_index.its | 216 |
| abstract_inverted_index.low | 92 |
| abstract_inverted_index.the | 40, 86, 110, 115, 119, 179, 232, 240, 243, 254, 260, 266, 295 |
| abstract_inverted_index.was | 157, 212, 281 |
| abstract_inverted_index.EZH2 | 87, 127, 214, 244 |
| abstract_inverted_index.HPV- | 235 |
| abstract_inverted_index.KEGG | 189 |
| abstract_inverted_index.This | 117, 291 |
| abstract_inverted_index.also | 227 |
| abstract_inverted_index.been | 5 |
| abstract_inverted_index.cell | 14 |
| abstract_inverted_index.data | 182 |
| abstract_inverted_index.from | 183 |
| abstract_inverted_index.into | 114 |
| abstract_inverted_index.lead | 80 |
| abstract_inverted_index.mRNA | 251 |
| abstract_inverted_index.more | 101 |
| abstract_inverted_index.pose | 71 |
| abstract_inverted_index.such | 38 |
| abstract_inverted_index.were | 171, 226 |
| abstract_inverted_index.with | 47, 140, 181, 259, 288 |
| abstract_inverted_index.(HPV) | 3 |
| abstract_inverted_index.(IPA) | 187 |
| abstract_inverted_index.E6/E7 | 153 |
| abstract_inverted_index.EZH2, | 166, 269 |
| abstract_inverted_index.Human | 1 |
| abstract_inverted_index.Ki-67 | 270 |
| abstract_inverted_index.There | 247 |
| abstract_inverted_index.block | 73 |
| abstract_inverted_index.could | 79 |
| abstract_inverted_index.eight | 138 |
| abstract_inverted_index.field | 45 |
| abstract_inverted_index.first | 120 |
| abstract_inverted_index.index | 221 |
| abstract_inverted_index.known | 65 |
| abstract_inverted_index.lends | 297 |
| abstract_inverted_index.real. | 51 |
| abstract_inverted_index.state | 103 |
| abstract_inverted_index.study | 121, 136 |
| abstract_inverted_index.turn, | 78 |
| abstract_inverted_index.using | 122, 303 |
| abstract_inverted_index.zeste | 60 |
| abstract_inverted_index.(IHC). | 148 |
| abstract_inverted_index.(OPC). | 133 |
| abstract_inverted_index.(mRNA) | 156 |
| abstract_inverted_index.Ki-67, | 167 |
| abstract_inverted_index.benign | 102 |
| abstract_inverted_index.effect | 46 |
| abstract_inverted_index.factor | 10 |
| abstract_inverted_index.itself | 298 |
| abstract_inverted_index.remove | 37 |
| abstract_inverted_index.tissue | 150 |
| abstract_inverted_index.(EZH2), | 63 |
| abstract_inverted_index.(Ki-67) | 222 |
| abstract_inverted_index.Methods | 134 |
| abstract_inverted_index.Pathway | 185 |
| abstract_inverted_index.Results | 200 |
| abstract_inverted_index.because | 294 |
| abstract_inverted_index.between | 234 |
| abstract_inverted_index.biology | 280, 296 |
| abstract_inverted_index.disease | 49, 107 |
| abstract_inverted_index.further | 198 |
| abstract_inverted_index.genome. | 116 |
| abstract_inverted_index.homolog | 61 |
| abstract_inverted_index.in-situ | 161 |
| abstract_inverted_index.indices | 170 |
| abstract_inverted_index.leading | 30 |
| abstract_inverted_index.mitotic | 169, 224, 272 |
| abstract_inverted_index.network | 195, 279 |
| abstract_inverted_index.options | 302 |
| abstract_inverted_index.pathway | 88, 196 |
| abstract_inverted_index.prevent | 105, 313 |
| abstract_inverted_index.promote | 67, 97 |
| abstract_inverted_index.protein | 128 |
| abstract_inverted_index.results | 180 |
| abstract_inverted_index.tumors, | 39 |
| abstract_inverted_index.Although | 33 |
| abstract_inverted_index.Analysis | 186 |
| abstract_inverted_index.However, | 85 |
| abstract_inverted_index.amenable | 90 |
| abstract_inverted_index.assessed | 172 |
| abstract_inverted_index.blocking | 28 |
| abstract_inverted_index.clinical | 123 |
| abstract_inverted_index.designed | 95 |
| abstract_inverted_index.disease. | 318 |
| abstract_inverted_index.effector | 54 |
| abstract_inverted_index.elevated | 219 |
| abstract_inverted_index.enhancer | 58 |
| abstract_inverted_index.evidence | 252 |
| abstract_inverted_index.expanded | 178 |
| abstract_inverted_index.included | 137 |
| abstract_inverted_index.measured | 158 |
| abstract_inverted_index.pathway. | 245 |
| abstract_inverted_index.patients | 139 |
| abstract_inverted_index.positive | 145, 209 |
| abstract_inverted_index.present. | 228 |
| abstract_inverted_index.squamous | 13 |
| abstract_inverted_index.surgical | 34 |
| abstract_inverted_index.targeted | 300 |
| abstract_inverted_index.toxicity | 93 |
| abstract_inverted_index.Ingenuity | 184 |
| abstract_inverted_index.analysis. | 175 |
| abstract_inverted_index.analytics | 177, 230, 285 |
| abstract_inverted_index.carcinoma | 132, 211 |
| abstract_inverted_index.celecoxib | 306 |
| abstract_inverted_index.confirmed | 143, 282 |
| abstract_inverted_index.construct | 192 |
| abstract_inverted_index.curcumin, | 305 |
| abstract_inverted_index.databases | 190 |
| abstract_inverted_index.etiologic | 44 |
| abstract_inverted_index.including | 218 |
| abstract_inverted_index.infection | 258 |
| abstract_inverted_index.insights. | 199 |
| abstract_inverted_index.malignant | 83 |
| abstract_inverted_index.messenger | 154 |
| abstract_inverted_index.molecular | 194, 278 |
| abstract_inverted_index.oncogenes | 21, 206, 264 |
| abstract_inverted_index.p16INK4a- | 144, 208 |
| abstract_inverted_index.potential | 41 |
| abstract_inverted_index.promoting | 25 |
| abstract_inverted_index.published | 289 |
| abstract_inverted_index.recurrent | 48, 106 |
| abstract_inverted_index.specimens | 124 |
| abstract_inverted_index.therapies | 94 |
| abstract_inverted_index.validated | 231 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Biomedical | 176, 229 |
| abstract_inverted_index.Conclusion | 246 |
| abstract_inverted_index.Expression | 164, 201 |
| abstract_inverted_index.RNAscope® | 160 |
| abstract_inverted_index.biomedical | 284 |
| abstract_inverted_index.carcinoma, | 142 |
| abstract_inverted_index.carcinoma. | 15, 276 |
| abstract_inverted_index.confirmed. | 213 |
| abstract_inverted_index.consistent | 287 |
| abstract_inverted_index.downstream | 53 |
| abstract_inverted_index.expression | 129, 151, 241, 267 |
| abstract_inverted_index.identified | 6 |
| abstract_inverted_index.inhibiting | 109 |
| abstract_inverted_index.metformin, | 304 |
| abstract_inverted_index.recurrence | 316 |
| abstract_inverted_index.strategies | 311 |
| abstract_inverted_index.HPV-induced | 82 |
| abstract_inverted_index.association | 255 |
| abstract_inverted_index.correlates, | 217 |
| abstract_inverted_index.demonstrate | 126 |
| abstract_inverted_index.literature. | 290 |
| abstract_inverted_index.progression | 225, 273, 314 |
| abstract_inverted_index.significant | 293 |
| abstract_inverted_index.technology. | 163 |
| abstract_inverted_index.therapeutic | 301, 310 |
| abstract_inverted_index.instrumental | 23 |
| abstract_inverted_index.intervention | 35 |
| abstract_inverted_index.oncoprotein, | 57 |
| abstract_inverted_index.p16INK4a-HPV | 257 |
| abstract_inverted_index.relationship | 233 |
| abstract_inverted_index.sulforaphane | 308 |
| abstract_inverted_index.hybridization | 162 |
| abstract_inverted_index.incorporation | 111 |
| abstract_inverted_index.oropharyngeal | 12, 131, 141, 210, 275 |
| abstract_inverted_index.proliferation | 26, 68, 220 |
| abstract_inverted_index.papillomavirus | 2 |
| abstract_inverted_index.tumorigenesis. | 32 |
| abstract_inverted_index.differentiation | 29, 75, 98 |
| abstract_inverted_index.morphoproteomic | 174, 249 |
| abstract_inverted_index.transformation. | 84 |
| abstract_inverted_index.etiopathogenetic | 9 |
| abstract_inverted_index.immunohistochemistry | 147 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5053758493 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I919571938 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7799999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.62228261 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |