Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging Article Swipe
Woei‐Yuh Saw
,
Kangjin Kim
,
Yichen Huang
,
Jeong H. Yun
,
Xiaolong Ma
,
Jason Bacon
,
Yash Pershad
,
Daniel Levy
,
George O'connor
,
Eric Boerwinkle
,
R. Graham Barr
,
Stephen S. Rich
,
Jerome I. Rotter
,
April P. Carson
,
Laura M. Raffield
,
Sina A. Gharib
,
Traci M. Bartz
,
Bruce M. Psaty
,
Tamar Sofer
,
Kari E. North
,
Robert C. Kaplan
,
Elizabeth C. Oelsner
,
Ani Manichaikul
,
Alexander G. Bick
,
Paul Sheet
,
Alexander P. Reiner
,
Yasminka A. Jakubek
,
Paul L. Auer
,
Michael H. Cho
,
Dawn L. DeMeo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.07.30.25332379
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.07.30.25332379
Mosaic loss of Y chromosome (mLOY) in blood cells is an age-related somatic mutation, but its relationship with pulmonary health remains undercharacterized. Leveraging mLOY assessment in over 12,000 men, including 5,097 from the COPDGene Study and 7,235 from six additional cohorts in Trans-Omics for Precision Medicine program, we investigated its association with respiratory outcomes and epigenetic aging. Cross-sectionally, mLOY was associated with airflow obstruction with prevalence increasing with age, particularly in men with a former smoking history. Longitudinally, mLOY associated with lung function decline. Notably, mLOY was also associated with greater CT-quantified lung emphysema and faster pace epigenetic aging. Prospectively, in participants with normal lung function at baseline, mLOY was associated with lower future lung function and faster pace of epigenetic aging. These associations remained robust after adjusting for clonal hematopoiesis and telomere length. Collectively, these findings position mLOY as a potential biomarker of respiratory aging and obstructive lung disease. Graphical Abstract
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.07.30.25332379
- https://www.medrxiv.org/content/medrxiv/early/2025/07/30/2025.07.30.25332379.full.pdf
- OA Status
- green
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412773839
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412773839Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2025.07.30.25332379Digital Object Identifier
- Title
-
Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic agingWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-30Full publication date if available
- Authors
-
Woei‐Yuh Saw, Kangjin Kim, Yichen Huang, Jeong H. Yun, Xiaolong Ma, Jason Bacon, Yash Pershad, Daniel Levy, George O'connor, Eric Boerwinkle, R. Graham Barr, Stephen S. Rich, Jerome I. Rotter, April P. Carson, Laura M. Raffield, Sina A. Gharib, Traci M. Bartz, Bruce M. Psaty, Tamar Sofer, Kari E. North, Robert C. Kaplan, Elizabeth C. Oelsner, Ani Manichaikul, Alexander G. Bick, Paul Sheet, Alexander P. Reiner, Yasminka A. Jakubek, Paul L. Auer, Michael H. Cho, Dawn L. DeMeoList of authors in order
- Landing page
-
https://doi.org/10.1101/2025.07.30.25332379Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2025/07/30/2025.07.30.25332379.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2025/07/30/2025.07.30.25332379.full.pdfDirect OA link when available
- Concepts
-
Epigenetics, Biomarker, Lung, COPD, Telomere, Medicine, Senescence, Internal medicine, Oncology, Biology, Bioinformatics, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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