Mouse models of acute and chronic hepacivirus infection Article Swipe
Eva Billerbeck
,
Raphael Wolfisberg
,
Ulrik Fahnøe
,
Jing Xiao
,
Corrine Quirk
,
Joseph M. Luna
,
John M. Cullen
,
Alex S. Hartlage
,
Luis Chiriboga
,
Kalpana Ghoshal
,
W. Ian Lipkin
,
Jens Bukh
,
Troels K. H. Scheel
,
Amit Kapoor
,
Charles M. Rice
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1126/science.aal1962
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1126/science.aal1962
New York City rats provide a gift to virologists Despite the development of curative drugs for hepatitis C virus (HCV) infection, global eradication of HCV will likely require a prophylactic vaccine. Progress toward a vaccine has been impeded by the absence of mouse models suitable for studying the immune response to HCV. Billerbeck et al. found that a HCV-related virus isolated from New York City rats produces an infection in laboratory mice that shares several immunological features with human infections (see the Perspective by Klenerman and Barnes). Their initial analyses of the infected mice revealed that acute clearance of the virus was dependent on T cells but not on natural killer cells. Science , this issue p. 204 ; see also p. 129
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1126/science.aal1962
- OA Status
- green
- Cited By
- 131
- References
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W2735158345Canonical identifier for this work in OpenAlex
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https://doi.org/10.1126/science.aal1962Digital Object Identifier
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Mouse models of acute and chronic hepacivirus infectionWork title
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articleOpenAlex work type
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enPrimary language
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2017Year of publication
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2017-07-14Full publication date if available
- Authors
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Eva Billerbeck, Raphael Wolfisberg, Ulrik Fahnøe, Jing Xiao, Corrine Quirk, Joseph M. Luna, John M. Cullen, Alex S. Hartlage, Luis Chiriboga, Kalpana Ghoshal, W. Ian Lipkin, Jens Bukh, Troels K. H. Scheel, Amit Kapoor, Charles M. RiceList of authors in order
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https://doi.org/10.1126/science.aal1962Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.1126/science.aal1962Direct OA link when available
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Virology, Medicine, Immunology, BiologyTop concepts (fields/topics) attached by OpenAlex
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131Total citation count in OpenAlex
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2025: 16, 2024: 15, 2023: 10, 2022: 9, 2021: 14Per-year citation counts (last 5 years)
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23Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| publication_date | 2017-07-14 |
| publication_year | 2017 |
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