MP09-11 MARKED INCREASE IN MITOCHONDRIAL RESPIRATION, HYDROGEN PEROXIDE EMITTING POTENTIAL AND ATP PRODUCTION IN THE UROTHELIUM VERSUS DETRUSOR SMOOTH MUSCLE Article Swipe

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Trevor C. Hunt , Michael R. Odom , Elena S. Pak , Michael D. Tarpey , Chien‐Te Lin , Darrell Neufer , Espen E. Spangenburg , Johanna L. Hannan ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.1016/j.juro.2018.02.337

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology & Pharmacology I1 Apr 2018MP09-11 MARKED INCREASE IN MITOCHONDRIAL RESPIRATION, HYDROGEN PEROXIDE EMITTING POTENTIAL AND ATP PRODUCTION IN THE UROTHELIUM VERSUS DETRUSOR SMOOTH MUSCLE Trevor Hunt, Michael Odom, Elena Pak, Michael Tarpey, Chien-Te Lin, Darrell Neufer, Espen Spangenburg, and Johanna Hannan Trevor HuntTrevor Hunt More articles by this author , Michael OdomMichael Odom More articles by this author , Elena PakElena Pak More articles by this author , Michael TarpeyMichael Tarpey More articles by this author , Chien-Te LinChien-Te Lin More articles by this author , Darrell NeuferDarrell Neufer More articles by this author , Espen SpangenburgEspen Spangenburg More articles by this author , and Johanna HannanJohanna Hannan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.337AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The bladder urothelium and detrusor smooth muscle both play important distinct roles in voiding. Many studies have shown that the urothelium can release both luminal and apical ATP in response to stimulation and ATP release is enhanced under diseased states. ATP is primarily produced by the electron transport chain within the mitochondria. The mitochondria are also responsible for regulating cellular metabolism and homeostasis. This study aims to characterize mitochondrial function in the urothelium and detrusor smooth muscle under normal physiological conditions. METHODS Bladders were excised from adult male C57BL/6N mice (16wks, n=10), cut open longitudinally and the urothelium layer was carefully removed as a whole sheet. The urothelium and detrusor were subdivided into smaller pieces and places in the Oroboros Oxygraph-2K. High-resolution respirometry measured mitochondrial oxygen consumption at complexes I, II, and IV in isolated urothelium and detrusor samples. Mitochondrial derived hydrogen peroxide (H2O2) emission was also measured. Simultaneous measurement of mitochondrial respiration and ATP production was assessed in both tissues to determine the phosphate to oxygen (P:O) ratio, a measure of ATP production. Mitochondrial content was measured via citrate synthase assay and OXPHOS protein expression. RESULTS Mitochondrial oxygen consumption rates in the bladder was doubled in the urothelium at complex I, complex IV, and complexes I+II compared to the detrusor smooth muscle (p<0.05). Additionally, the urothelium was able to emit significantly greater amounts of H2O2 (p<0.05). The P:O ratio was also doubled int he urothelium indicating that it has a greater ability to generate ATP. Citrate synthase activity was unchanged between the detrusor and urothelium indicating that the amount of mitochondria is similar between groups. CONCLUSIONS This study is the first to examine mitochondrial respiration in intact urothelium and detrusor smooth muscle. The urothelium has greater rates of mitochondrial respiration, H2O2 emission potential and ATP production compared to the detrusor smooth muscle. Interestingly there was no change in citrate synthase activity indicating that there are distinct differences in mitochondrial function between these two tissue types within the bladder. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e110 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Trevor Hunt More articles by this author Michael Odom More articles by this author Elena Pak More articles by this author Michael Tarpey More articles by this author Chien-Te Lin More articles by this author Darrell Neufer More articles by this author Espen Spangenburg More articles by this author Johanna Hannan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

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Urothelium Mitochondrion Detrusor muscle Medicine Urinary bladder Cell biology Biology Internal medicine

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Landing Page: https://doi.org/10.1016/j.juro.2018.02.337
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Title: MP09-11 MARKED INCREASE IN MITOCHONDRIAL RESPIRATION, HYDROGEN PEROXIDE EMITTING POTENTIAL AND ATP PRODUCTION IN THE UROTHELIUM VERSUS DETRUSOR SMOOTH MUSCLE

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Publication year: 2018

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Authors: Trevor C. Hunt, Michael R. Odom, Elena S. Pak, Michael D. Tarpey, Chien‐Te Lin, Darrell Neufer, Espen E. Spangenburg, Johanna L. Hannan

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Landing page: https://doi.org/10.1016/j.juro.2018.02.337

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Concepts: Urothelium, Mitochondrion, Detrusor muscle, Medicine, Urinary bladder, Cell biology, Biology, Internal medicine

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abstract_inverted_index....	540
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abstract_inverted_index.ATP	24, 163, 169, 176, 290, 308, 431
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abstract_inverted_index.Apr	12
abstract_inverted_index.II,	266
abstract_inverted_index.IV,	339
abstract_inverted_index.Lin	88, 507
abstract_inverted_index.P:O	364
abstract_inverted_index.PDF	538
abstract_inverted_index.Pak	70, 493
abstract_inverted_index.THE	27
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abstract_inverted_index.two	459
abstract_inverted_index.via	314
abstract_inverted_index.was	235, 281, 292, 312, 330, 353, 366, 385, 441
abstract_inverted_index.ATP.	381
abstract_inverted_index.H2O2	361, 427
abstract_inverted_index.Hunt	52, 479
abstract_inverted_index.I+II	342
abstract_inverted_index.Lin,	42
abstract_inverted_index.Many	150
abstract_inverted_index.More	53, 62, 71, 80, 89, 98, 107, 117, 480, 487, 494, 501, 508, 515, 522, 529
abstract_inverted_index.Odom	61, 486
abstract_inverted_index.Pak,	38
abstract_inverted_index.This	199, 403
abstract_inverted_index.View	122
abstract_inverted_index.able	354
abstract_inverted_index.aims	201
abstract_inverted_index.also	191, 282, 367
abstract_inverted_index.both	143, 159, 295
abstract_inverted_index.e110	471
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abstract_inverted_index.that	154, 373, 393, 449
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abstract_inverted_index.(P:O)	303
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abstract_inverted_index.Hunt,	34
abstract_inverted_index.Odom,	36
abstract_inverted_index.adult	222
abstract_inverted_index.assay	317
abstract_inverted_index.chain	184
abstract_inverted_index.first	407
abstract_inverted_index.layer	234
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abstract_inverted_index.whole	240
abstract_inverted_index.(H2O2)	279
abstract_inverted_index.Author	124
abstract_inverted_index.Expand	534
abstract_inverted_index.Hannan	49, 116, 528
abstract_inverted_index.MARKED	14
abstract_inverted_index.MUSCLE	32
abstract_inverted_index.Neufer	97, 514
abstract_inverted_index.OXPHOS	319
abstract_inverted_index.SMOOTH	31
abstract_inverted_index.Tarpey	79, 500
abstract_inverted_index.Trevor	33, 50, 478
abstract_inverted_index.VERSUS	29
abstract_inverted_index.Volume	467
abstract_inverted_index.amount	395
abstract_inverted_index.apical	162
abstract_inverted_index.author	57, 66, 75, 84, 93, 102, 111, 121, 484, 491, 498, 505, 512, 519, 526, 533
abstract_inverted_index.change	443
abstract_inverted_index.intact	413
abstract_inverted_index.muscle	142, 212, 348
abstract_inverted_index.n=10),	227
abstract_inverted_index.normal	214
abstract_inverted_index.oxygen	261, 302, 324
abstract_inverted_index.pieces	250
abstract_inverted_index.places	252
abstract_inverted_index.ratio,	304
abstract_inverted_index.sheet.	241
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abstract_inverted_index.(16wks,	226
abstract_inverted_index.4SApril	469
abstract_inverted_index.Citrate	382
abstract_inverted_index.Darrell	43, 95, 513
abstract_inverted_index.InEmail	132
abstract_inverted_index.Johanna	48, 114, 527
abstract_inverted_index.METHODS	217
abstract_inverted_index.Michael	35, 39, 59, 77, 485, 499
abstract_inverted_index.Neufer,	44
abstract_inverted_index.RESULTS	322
abstract_inverted_index.Tarpey,	40
abstract_inverted_index.ability	378
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abstract_inverted_index.between	387, 400, 457
abstract_inverted_index.bladder	137, 329
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abstract_inverted_index.derived	276
abstract_inverted_index.doubled	331, 368
abstract_inverted_index.examine	409
abstract_inverted_index.excised	220
abstract_inverted_index.greater	358, 377, 422
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abstract_inverted_index.muscle.	418, 438
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abstract_inverted_index.release	158, 170
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abstract_inverted_index.smaller	249
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abstract_inverted_index.199Issue	468
abstract_inverted_index.Anatomy,	7
abstract_inverted_index.Bladders	218
abstract_inverted_index.C57BL/6N	224
abstract_inverted_index.Chien-Te	41, 86, 506
abstract_inverted_index.DETRUSOR	30
abstract_inverted_index.EMITTING	21
abstract_inverted_index.HYDROGEN	19
abstract_inverted_index.INCREASE	15
abstract_inverted_index.Oroboros	255
abstract_inverted_index.PEROXIDE	20
abstract_inverted_index.PakElena	69
abstract_inverted_index.ToolsAdd	126
abstract_inverted_index.Urethra:	6
abstract_inverted_index.activity	384, 447
abstract_inverted_index.articles	54, 63, 72, 81, 90, 99, 108, 118, 481, 488, 495, 502, 509, 516, 523, 530
abstract_inverted_index.assessed	293
abstract_inverted_index.bladder.	464
abstract_inverted_index.cellular	195
abstract_inverted_index.compared	343, 433
abstract_inverted_index.detrusor	140, 210, 245, 273, 346, 389, 416, 436
abstract_inverted_index.diseased	174
abstract_inverted_index.distinct	146, 452
abstract_inverted_index.electron	182
abstract_inverted_index.emission	280, 428
abstract_inverted_index.enhanced	172
abstract_inverted_index.function	205, 456
abstract_inverted_index.generate	380
abstract_inverted_index.hydrogen	277
abstract_inverted_index.isolated	270
abstract_inverted_index.measured	259, 313
abstract_inverted_index.peroxide	278
abstract_inverted_index.produced	179
abstract_inverted_index.response	165
abstract_inverted_index.samples.	274
abstract_inverted_index.synthase	316, 383, 446
abstract_inverted_index.voiding.	149
abstract_inverted_index.(p<0.05).	349, 362
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abstract_inverted_index.Copyright	473
abstract_inverted_index.POTENTIAL	22
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abstract_inverted_index.complexes	264, 341
abstract_inverted_index.determine	298
abstract_inverted_index.important	145
abstract_inverted_index.measured.	283
abstract_inverted_index.phosphate	300
abstract_inverted_index.potential	429
abstract_inverted_index.primarily	178
abstract_inverted_index.transport	183
abstract_inverted_index.unchanged	386
abstract_inverted_index.HuntTrevor	51
abstract_inverted_index.OBJECTIVES	135
abstract_inverted_index.PRODUCTION	25
abstract_inverted_index.Physiology	8
abstract_inverted_index.UROTHELIUM	28
abstract_inverted_index.indicating	372, 392, 448
abstract_inverted_index.metabolism	196
abstract_inverted_index.production	291, 432
abstract_inverted_index.regulating	194
abstract_inverted_index.subdivided	247
abstract_inverted_index.urothelium	138, 156, 208, 233, 243, 271, 334, 352, 371, 391, 414, 420
abstract_inverted_index.2018MP09-11	13
abstract_inverted_index.CONCLUSIONS	402
abstract_inverted_index.Information	477
abstract_inverted_index.LinChien-Te	87
abstract_inverted_index.OdomMichael	60
abstract_inverted_index.Spangenburg	106, 521
abstract_inverted_index.conditions.	216
abstract_inverted_index.consumption	262, 325
abstract_inverted_index.differences	453
abstract_inverted_index.expression.	321
abstract_inverted_index.measurement	285
abstract_inverted_index.production.	309
abstract_inverted_index.respiration	288, 411
abstract_inverted_index.responsible	192
abstract_inverted_index.stimulation	167
abstract_inverted_index.INTRODUCTION	133
abstract_inverted_index.Oxygraph-2K.	256
abstract_inverted_index.Pharmacology	10
abstract_inverted_index.RESPIRATION,	18
abstract_inverted_index.Simultaneous	284
abstract_inverted_index.Spangenburg,	46
abstract_inverted_index.characterize	203
abstract_inverted_index.homeostasis.	198
abstract_inverted_index.mitochondria	189, 397
abstract_inverted_index.respiration,	426
abstract_inverted_index.respirometry	258
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abstract_inverted_index.Advertisement	472, 536, 537
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abstract_inverted_index.NeuferDarrell	96
abstract_inverted_index.Permissions©	475
abstract_inverted_index.TarpeyMichael	78
abstract_inverted_index.accessJournal	2
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abstract_inverted_index.mitochondrial	204, 260, 287, 410, 425, 455
abstract_inverted_index.physiological	215
abstract_inverted_index.significantly	357
abstract_inverted_index.CitationsTrack	129
abstract_inverted_index.UrologyBladder	4
abstract_inverted_index.longitudinally	230
abstract_inverted_index.High-resolution	257
abstract_inverted_index.downloadLoading	539
abstract_inverted_index.SpangenburgEspen	105
abstract_inverted_index.2018MetricsAuthor	476
abstract_inverted_index.favoritesDownload	128
abstract_inverted_index.ShareFacebookTwitterLinked	131
abstract_inverted_index.CitationsPermissionsReprints	130
abstract_inverted_index.2018FiguresReferencesRelatedDetails	466
abstract_inverted_index.Informationhttps://doi.org/10.1016/j.juro.2018.02.337AboutPDF	125
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