MP53-16 EARLY SALVAGE RADIOTHERAPY FOR PATIENTS WITH ADVERSE PATHOLOGICAL FEATURES AFTER RADICAL PROSTATECTOMY: PRELIMINARY RESULTS FROM EASY-1 (EARLY SALVAGE RADIOTHERAPY-1) PROTOCOL Article Swipe

You have accessJournal of UrologyProstate Cancer: Localized: Radiation Therapy (MP53)1 Apr 2020MP53-16 EARLY SALVAGE RADIOTHERAPY FOR PATIENTS WITH ADVERSE PATHOLOGICAL FEATURES AFTER RADICAL PROSTATECTOMY: PRELIMINARY RESULTS FROM EASY-1 (EARLY SALVAGE RADIOTHERAPY-1) PROTOCOL Matteo Droghetti*, Lorenzo Bianchi, Riccardo Schiavina, Marco Borghesi, Paolo Sadini, Carlo Beretta, Valeria Dionisi, Maria Ntreta, Giambattista Siepe, Alessandra Arcelli, A Benini, S Cammelli, Alessio Giuseppe Morganti, and Eugenio Brunocilla Matteo Droghetti*Matteo Droghetti* More articles by this author , Lorenzo BianchiLorenzo Bianchi More articles by this author , Riccardo SchiavinaRiccardo Schiavina More articles by this author , Marco BorghesiMarco Borghesi More articles by this author , Paolo SadiniPaolo Sadini More articles by this author , Carlo BerettaCarlo Beretta More articles by this author , Valeria DionisiValeria Dionisi More articles by this author , Maria NtretaMaria Ntreta More articles by this author , Giambattista SiepeGiambattista Siepe More articles by this author , Alessandra ArcelliAlessandra Arcelli More articles by this author , A BeniniA Benini More articles by this author , S CammelliS Cammelli More articles by this author , Alessio Giuseppe MorgantiAlessio Giuseppe Morganti More articles by this author , and Eugenio BrunocillaEugenio Brunocilla More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000915.016AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The aim of this study is to evaluate the biochemical recurrence (BCR) free survival (BCR-FS) in man with intermediate-high risk of recurrence after radical prostatectomy (RP) for prostate cancer (PCa). METHODS: We prospectively enrolled 267 PCa patients submitted to RP between October 2016 and December 2018 at our Institution and included in a IRB-approved follow-up protocol (EASY-1: EArly Salvage RadiotherapY-1). Inclusion criteria were: PCa patients treated with RP; pathologic pT2 R1 N0 or pT3a R0 N0 or pT3a R1 N0 or pT3b R0 N0; PSA undetectable at 40 days after surgery. The surveillance protocol included PSA dosage every two months after surgery during the first year, then every three months during the second and third year, and every 4 months till the fifth year. Early sRT has been performed for patients with BCR (two consecutive values of PSA ≥0.2 ng/ml) and PSA value ≤ 0.5 ng/ml. RESULTS: From the initial cohort, 8 patients were excluded, due to PSA values at 40 days higher than 0,1 ng/mL and scheduled for aRT. Overall 70 (27%), 116 (44.8%), 52 (20.1%) and 21 (8.1%) patients revealed pT2R1, pT3aR0, pT3aR1 and pT3bR0 disease, respectively. Patients in the BCR group had higher Gleason Score at pathologic examination (p<0.01) and longer positive surgical margin extension (p=0.002 ). The median (IQR) follow-up of the entire population was 16 (9-25) months. The median (IQR) time to BCR was 12 (8-18) months, with a median PSA at BCR of 0.2 ng/mL (0.17 – 0.35). The overall BCR free survival (BCR-FS) rate was 92% at 1 year. After stratifying according to pathologic characteristics , the BCR-FS at 1 year rates were 94%, 96%, 88% and 84% in pT2 R1, pT3a R0, pT3a R1 and pT3b R0, respectively (p=0.17). CONCLUSIONS: Strict surveillance and early detection of BCR can spare immediate aRT and defer sRT within 1 year in a consistent proportion of PCa patients with intermediate-high risk of recurrence after RP. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e788-e789 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Matteo Droghetti* More articles by this author Lorenzo Bianchi More articles by this author Riccardo Schiavina More articles by this author Marco Borghesi More articles by this author Paolo Sadini More articles by this author Carlo Beretta More articles by this author Valeria Dionisi More articles by this author Maria Ntreta More articles by this author Giambattista Siepe More articles by this author Alessandra Arcelli More articles by this author A Benini More articles by this author S Cammelli More articles by this author Alessio Giuseppe Morganti More articles by this author Eugenio Brunocilla More articles by this author Expand All Advertisement PDF downloadLoading ...