mRNA structure determines specificity of a polyQ-driven phase separation Article Swipe
Erin M. Langdon
,
Yupeng Qiu
,
Amirhossein Ghanbari Niaki
,
Grace A. McLaughlin
,
Chase A. Weidmann
,
Therese M. Gerbich
,
Jean A. Smith
,
John Crutchley
,
Christina M. Termini
,
Kevin M. Weeks
,
Sua Myong
,
Amy S. Gladfelter
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1126/science.aar7432
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1126/science.aar7432
RNA and membraneless organelles Membraneless compartments can form in cells through liquidliquid phase separation (see the Perspective by Polymenidou). But what prevents these cellular condensates from randomly fusing together? Using the RNA-binding protein (RBP) Whi3, Langdon et al. demonstrated that the secondary structure of different RNA components determines the distinct biophysical and biological properties of the two types of condensates that Whi3 forms. Several RBPs, such as FUS and TDP43, contain prion-like domains and are linked to neurodegenerative diseases. These RBPs are usually soluble in the nucleus but can form pathological aggregates in the cytoplasm. Maharana et al. showed that local RNA concentrations determine distinct phase separation behaviors in different subcellular locations. The higher RNA concentrations in the nucleus act as a buffer to prevent phase separation of RBPs; when mislocalized to the cytoplasm, lower RNA concentrations trigger aggregation. Science , this issue p. 922 , p. 918 ; see also p. 859
Related Topics
Concepts
RNA
Messenger RNA
Nucleic acid structure
Cell biology
RNA-binding protein
Biophysics
Rna processing
RNA editing
Biology
Chemistry
Biochemistry
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1126/science.aar7432
- OA Status
- green
- Cited By
- 522
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2776559018
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2776559018Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1126/science.aar7432Digital Object Identifier
- Title
-
mRNA structure determines specificity of a polyQ-driven phase separationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-04-12Full publication date if available
- Authors
-
Erin M. Langdon, Yupeng Qiu, Amirhossein Ghanbari Niaki, Grace A. McLaughlin, Chase A. Weidmann, Therese M. Gerbich, Jean A. Smith, John Crutchley, Christina M. Termini, Kevin M. Weeks, Sua Myong, Amy S. GladfelterList of authors in order
- Landing page
-
https://doi.org/10.1126/science.aar7432Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/6192030Direct OA link when available
- Concepts
-
RNA, Messenger RNA, Nucleic acid structure, Cell biology, RNA-binding protein, Biophysics, Rna processing, RNA editing, Biology, Chemistry, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
522Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 39, 2024: 53, 2023: 71, 2022: 51, 2021: 105Per-year citation counts (last 5 years)
- References (count)
-
20Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2776559018 |
|---|---|
| doi | https://doi.org/10.1126/science.aar7432 |
| ids.doi | https://doi.org/10.1126/science.aar7432 |
| ids.mag | 2776559018 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/29650703 |
| ids.openalex | https://openalex.org/W2776559018 |
| fwci | 33.41663905 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D001483 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Base Sequence |
| mesh[1].qualifier_ui | Q000737 |
| mesh[1].descriptor_ui | D016213 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | chemistry |
| mesh[1].descriptor_name | Cyclins |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D009690 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Nucleic Acid Conformation |
| mesh[3].qualifier_ui | Q000737 |
| mesh[3].descriptor_ui | D010455 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | chemistry |
| mesh[3].descriptor_name | Peptides |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D044367 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Phase Transition |
| mesh[5].qualifier_ui | Q000737 |
| mesh[5].descriptor_ui | D012333 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | chemistry |
| mesh[5].descriptor_name | RNA, Messenger |
| mesh[6].qualifier_ui | Q000737 |
| mesh[6].descriptor_ui | D016601 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | chemistry |
| mesh[6].descriptor_name | RNA-Binding Proteins |
| mesh[7].qualifier_ui | Q000737 |
| mesh[7].descriptor_ui | D029701 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | chemistry |
| mesh[7].descriptor_name | Saccharomyces cerevisiae Proteins |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D001483 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Base Sequence |
| mesh[9].qualifier_ui | Q000737 |
| mesh[9].descriptor_ui | D016213 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | chemistry |
| mesh[9].descriptor_name | Cyclins |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D009690 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Nucleic Acid Conformation |
| mesh[11].qualifier_ui | Q000737 |
| mesh[11].descriptor_ui | D010455 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | chemistry |
| mesh[11].descriptor_name | Peptides |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D044367 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Phase Transition |
| mesh[13].qualifier_ui | Q000737 |
| mesh[13].descriptor_ui | D012333 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | chemistry |
| mesh[13].descriptor_name | RNA, Messenger |
| mesh[14].qualifier_ui | Q000737 |
| mesh[14].descriptor_ui | D016601 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | chemistry |
| mesh[14].descriptor_name | RNA-Binding Proteins |
| mesh[15].qualifier_ui | Q000737 |
| mesh[15].descriptor_ui | D029701 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | chemistry |
| mesh[15].descriptor_name | Saccharomyces cerevisiae Proteins |
| type | article |
| title | mRNA structure determines specificity of a polyQ-driven phase separation |
| awards[0].id | https://openalex.org/G1573289454 |
| awards[0].funder_id | https://openalex.org/F4320306082 |
| awards[0].display_name | |
| awards[0].funder_award_id | Faculty Scholars Program |
| awards[0].funder_display_name | Howard Hughes Medical Institute |
| awards[1].id | https://openalex.org/G4053322873 |
| awards[1].funder_id | https://openalex.org/F4320332161 |
| awards[1].display_name | |
| awards[1].funder_award_id | R01 GM115631 |
| awards[1].funder_display_name | National Institutes of Health |
| awards[2].id | https://openalex.org/G6778906191 |
| awards[2].funder_id | https://openalex.org/F4320308355 |
| awards[2].display_name | |
| awards[2].funder_award_id | 130845-RSG-17-114-01-RMC |
| awards[2].funder_display_name | American Chemical Society |
| biblio.issue | 6391 |
| biblio.volume | 360 |
| biblio.last_page | 927 |
| biblio.first_page | 922 |
| topics[0].id | https://openalex.org/T10604 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | RNA Research and Splicing |
| topics[1].id | https://openalex.org/T11482 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9983999729156494 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | RNA modifications and cancer |
| topics[2].id | https://openalex.org/T10521 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9958999752998352 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | RNA and protein synthesis mechanisms |
| funders[0].id | https://openalex.org/F4320306082 |
| funders[0].ror | https://ror.org/006w34k90 |
| funders[0].display_name | Howard Hughes Medical Institute |
| funders[1].id | https://openalex.org/F4320308355 |
| funders[1].ror | https://ror.org/059dqb057 |
| funders[1].display_name | American Chemical Society |
| funders[2].id | https://openalex.org/F4320332161 |
| funders[2].ror | https://ror.org/01cwqze88 |
| funders[2].display_name | National Institutes of Health |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C67705224 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8833167552947998 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11053 |
| concepts[0].display_name | RNA |
| concepts[1].id | https://openalex.org/C105580179 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6928061842918396 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q188928 |
| concepts[1].display_name | Messenger RNA |
| concepts[2].id | https://openalex.org/C126142528 |
| concepts[2].level | 4 |
| concepts[2].score | 0.5196153521537781 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q3771876 |
| concepts[2].display_name | Nucleic acid structure |
| concepts[3].id | https://openalex.org/C95444343 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5101876258850098 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[3].display_name | Cell biology |
| concepts[4].id | https://openalex.org/C41282012 |
| concepts[4].level | 4 |
| concepts[4].score | 0.44494983553886414 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3928341 |
| concepts[4].display_name | RNA-binding protein |
| concepts[5].id | https://openalex.org/C12554922 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4415156841278076 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7100 |
| concepts[5].display_name | Biophysics |
| concepts[6].id | https://openalex.org/C2991743866 |
| concepts[6].level | 4 |
| concepts[6].score | 0.4352717697620392 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q417379 |
| concepts[6].display_name | Rna processing |
| concepts[7].id | https://openalex.org/C21786251 |
| concepts[7].level | 4 |
| concepts[7].score | 0.4342679977416992 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q14886350 |
| concepts[7].display_name | RNA editing |
| concepts[8].id | https://openalex.org/C86803240 |
| concepts[8].level | 0 |
| concepts[8].score | 0.42519497871398926 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[8].display_name | Biology |
| concepts[9].id | https://openalex.org/C185592680 |
| concepts[9].level | 0 |
| concepts[9].score | 0.40618276596069336 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[9].display_name | Chemistry |
| concepts[10].id | https://openalex.org/C55493867 |
| concepts[10].level | 1 |
| concepts[10].score | 0.2387428879737854 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[10].display_name | Biochemistry |
| concepts[11].id | https://openalex.org/C104317684 |
| concepts[11].level | 2 |
| concepts[11].score | 0.16004309058189392 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[11].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/rna |
| keywords[0].score | 0.8833167552947998 |
| keywords[0].display_name | RNA |
| keywords[1].id | https://openalex.org/keywords/messenger-rna |
| keywords[1].score | 0.6928061842918396 |
| keywords[1].display_name | Messenger RNA |
| keywords[2].id | https://openalex.org/keywords/nucleic-acid-structure |
| keywords[2].score | 0.5196153521537781 |
| keywords[2].display_name | Nucleic acid structure |
| keywords[3].id | https://openalex.org/keywords/cell-biology |
| keywords[3].score | 0.5101876258850098 |
| keywords[3].display_name | Cell biology |
| keywords[4].id | https://openalex.org/keywords/rna-binding-protein |
| keywords[4].score | 0.44494983553886414 |
| keywords[4].display_name | RNA-binding protein |
| keywords[5].id | https://openalex.org/keywords/biophysics |
| keywords[5].score | 0.4415156841278076 |
| keywords[5].display_name | Biophysics |
| keywords[6].id | https://openalex.org/keywords/rna-processing |
| keywords[6].score | 0.4352717697620392 |
| keywords[6].display_name | Rna processing |
| keywords[7].id | https://openalex.org/keywords/rna-editing |
| keywords[7].score | 0.4342679977416992 |
| keywords[7].display_name | RNA editing |
| keywords[8].id | https://openalex.org/keywords/biology |
| keywords[8].score | 0.42519497871398926 |
| keywords[8].display_name | Biology |
| keywords[9].id | https://openalex.org/keywords/chemistry |
| keywords[9].score | 0.40618276596069336 |
| keywords[9].display_name | Chemistry |
| keywords[10].id | https://openalex.org/keywords/biochemistry |
| keywords[10].score | 0.2387428879737854 |
| keywords[10].display_name | Biochemistry |
| keywords[11].id | https://openalex.org/keywords/gene |
| keywords[11].score | 0.16004309058189392 |
| keywords[11].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1126/science.aar7432 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S3880285 |
| locations[0].source.issn | 0036-8075, 1095-9203 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0036-8075 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Science |
| locations[0].source.host_organization | https://openalex.org/P4310315823 |
| locations[0].source.host_organization_name | American Association for the Advancement of Science |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315823 |
| locations[0].source.host_organization_lineage_names | American Association for the Advancement of Science |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Science |
| locations[0].landing_page_url | https://doi.org/10.1126/science.aar7432 |
| locations[1].id | pmid:29650703 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Science (New York, N.Y.) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/29650703 |
| locations[2].id | pmh:oai:europepmc.org:5208659 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | http://europepmc.org/pmc/articles/PMC6192030 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:6192030 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Science |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6192030 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5001482298 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9324-6215 |
| authorships[0].author.display_name | Erin M. Langdon |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[0].institutions[0].id | https://openalex.org/I114027177 |
| authorships[0].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Erin M. Langdon |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[1].author.id | https://openalex.org/A5113627430 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Yupeng Qiu |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I145311948 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. |
| authorships[1].institutions[0].id | https://openalex.org/I145311948 |
| authorships[1].institutions[0].ror | https://ror.org/00za53h95 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I145311948 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Johns Hopkins University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yupeng Qiu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. |
| authorships[2].author.id | https://openalex.org/A5013755755 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6174-2081 |
| authorships[2].author.display_name | Amirhossein Ghanbari Niaki |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I145311948 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. |
| authorships[2].institutions[0].id | https://openalex.org/I145311948 |
| authorships[2].institutions[0].ror | https://ror.org/00za53h95 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I145311948 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Johns Hopkins University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Amirhossein Ghanbari Niaki |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. |
| authorships[3].author.id | https://openalex.org/A5058429273 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Grace A. McLaughlin |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[3].institutions[0].id | https://openalex.org/I114027177 |
| authorships[3].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Grace A. McLaughlin |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[4].author.id | https://openalex.org/A5014076234 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-2941-0500 |
| authorships[4].author.display_name | Chase A. Weidmann |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[4].institutions[0].id | https://openalex.org/I114027177 |
| authorships[4].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Chase A. Weidmann |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[5].author.id | https://openalex.org/A5034563211 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-4232-9536 |
| authorships[5].author.display_name | Therese M. Gerbich |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[5].institutions[0].id | https://openalex.org/I114027177 |
| authorships[5].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Therese M. Gerbich |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[6].author.id | https://openalex.org/A5067662032 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-8981-9930 |
| authorships[6].author.display_name | Jean A. Smith |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[6].institutions[0].id | https://openalex.org/I114027177 |
| authorships[6].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Jean A. Smith |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[7].author.id | https://openalex.org/A5060875335 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | John Crutchley |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[7].institutions[0].id | https://openalex.org/I114027177 |
| authorships[7].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | John M. Crutchley |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[8].author.id | https://openalex.org/A5023815774 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-1831-1347 |
| authorships[8].author.display_name | Christina M. Termini |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I161318765 |
| authorships[8].affiliations[0].raw_affiliation_string | Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. |
| authorships[8].institutions[0].id | https://openalex.org/I161318765 |
| authorships[8].institutions[0].ror | https://ror.org/046rm7j60 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I161318765 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | University of California, Los Angeles |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Christina M. Termini |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. |
| authorships[9].author.id | https://openalex.org/A5050389355 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-6748-9985 |
| authorships[9].author.display_name | Kevin M. Weeks |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[9].institutions[0].id | https://openalex.org/I114027177 |
| authorships[9].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Kevin M. Weeks |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[10].author.id | https://openalex.org/A5070455339 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-9098-3423 |
| authorships[10].author.display_name | Sua Myong |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I145311948 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. |
| authorships[10].institutions[0].id | https://openalex.org/I145311948 |
| authorships[10].institutions[0].ror | https://ror.org/00za53h95 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I145311948 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Johns Hopkins University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Sua Myong |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. |
| authorships[11].author.id | https://openalex.org/A5014458109 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-2490-6945 |
| authorships[11].author.display_name | Amy S. Gladfelter |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I1338920048 |
| authorships[11].affiliations[0].raw_affiliation_string | Marine Biological Laboratory, Woods Hole, MA 02543, USA. |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[11].affiliations[1].raw_affiliation_string | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| authorships[11].institutions[0].id | https://openalex.org/I1338920048 |
| authorships[11].institutions[0].ror | https://ror.org/046dg4z72 |
| authorships[11].institutions[0].type | nonprofit |
| authorships[11].institutions[0].lineage | https://openalex.org/I1338920048 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | Marine Biological Laboratory |
| authorships[11].institutions[1].id | https://openalex.org/I114027177 |
| authorships[11].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[11].institutions[1].country_code | US |
| authorships[11].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Amy S. Gladfelter |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Marine Biological Laboratory, Woods Hole, MA 02543, USA. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6192030 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | mRNA structure determines specificity of a polyQ-driven phase separation |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T10604 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | RNA Research and Splicing |
| related_works | https://openalex.org/W4285606978, https://openalex.org/W2944756943, https://openalex.org/W2128019463, https://openalex.org/W2107139144, https://openalex.org/W2005140272, https://openalex.org/W58434765, https://openalex.org/W3093881476, https://openalex.org/W3190340083, https://openalex.org/W2071473901, https://openalex.org/W1499530579 |
| cited_by_count | 522 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 39 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 53 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 71 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 51 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 105 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 91 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 78 |
| counts_by_year[7].year | 2018 |
| counts_by_year[7].cited_by_count | 34 |
| locations_count | 4 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:6192030 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Science |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6192030 |
| primary_location.id | doi:10.1126/science.aar7432 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S3880285 |
| primary_location.source.issn | 0036-8075, 1095-9203 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0036-8075 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Science |
| primary_location.source.host_organization | https://openalex.org/P4310315823 |
| primary_location.source.host_organization_name | American Association for the Advancement of Science |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315823 |
| primary_location.source.host_organization_lineage_names | American Association for the Advancement of Science |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Science |
| primary_location.landing_page_url | https://doi.org/10.1126/science.aar7432 |
| publication_date | 2018-04-12 |
| publication_year | 2018 |
| referenced_works | https://openalex.org/W2590568317, https://openalex.org/W2756821926, https://openalex.org/W2102898524, https://openalex.org/W2949999790, https://openalex.org/W2111796925, https://openalex.org/W1854281301, https://openalex.org/W2131367252, https://openalex.org/W2064003266, https://openalex.org/W2036735052, https://openalex.org/W2595193911, https://openalex.org/W2025114495, https://openalex.org/W2074247664, https://openalex.org/W2014336792, https://openalex.org/W2617594926, https://openalex.org/W2212720078, https://openalex.org/W2517426057, https://openalex.org/W1062427742, https://openalex.org/W2791482849, https://openalex.org/W2167279371, https://openalex.org/W2767747597 |
| referenced_works_count | 20 |
| abstract_inverted_index., | 140, 145 |
| abstract_inverted_index.; | 148 |
| abstract_inverted_index.a | 121 |
| abstract_inverted_index.as | 66, 120 |
| abstract_inverted_index.by | 17 |
| abstract_inverted_index.et | 36, 96 |
| abstract_inverted_index.in | 8, 84, 92, 108, 116 |
| abstract_inverted_index.of | 43, 54, 58, 127 |
| abstract_inverted_index.p. | 143, 146, 151 |
| abstract_inverted_index.to | 76, 123, 131 |
| abstract_inverted_index.859 | 152 |
| abstract_inverted_index.918 | 147 |
| abstract_inverted_index.922 | 144 |
| abstract_inverted_index.But | 19 |
| abstract_inverted_index.FUS | 67 |
| abstract_inverted_index.RNA | 0, 45, 101, 114, 135 |
| abstract_inverted_index.The | 112 |
| abstract_inverted_index.act | 119 |
| abstract_inverted_index.al. | 37, 97 |
| abstract_inverted_index.and | 1, 51, 68, 73 |
| abstract_inverted_index.are | 74, 81 |
| abstract_inverted_index.but | 87 |
| abstract_inverted_index.can | 6, 88 |
| abstract_inverted_index.see | 149 |
| abstract_inverted_index.the | 15, 30, 40, 48, 55, 85, 93, 117, 132 |
| abstract_inverted_index.two | 56 |
| abstract_inverted_index.(see | 14 |
| abstract_inverted_index.RBPs | 80 |
| abstract_inverted_index.Whi3 | 61 |
| abstract_inverted_index.also | 150 |
| abstract_inverted_index.form | 7, 89 |
| abstract_inverted_index.from | 25 |
| abstract_inverted_index.such | 65 |
| abstract_inverted_index.that | 39, 60, 99 |
| abstract_inverted_index.this | 141 |
| abstract_inverted_index.what | 20 |
| abstract_inverted_index.when | 129 |
| abstract_inverted_index.(RBP) | 33 |
| abstract_inverted_index.RBPs, | 64 |
| abstract_inverted_index.RBPs; | 128 |
| abstract_inverted_index.These | 79 |
| abstract_inverted_index.Using | 29 |
| abstract_inverted_index.Whi3, | 34 |
| abstract_inverted_index.cells | 9 |
| abstract_inverted_index.issue | 142 |
| abstract_inverted_index.local | 100 |
| abstract_inverted_index.lower | 134 |
| abstract_inverted_index.phase | 12, 105, 125 |
| abstract_inverted_index.these | 22 |
| abstract_inverted_index.types | 57 |
| abstract_inverted_index.TDP43, | 69 |
| abstract_inverted_index.buffer | 122 |
| abstract_inverted_index.forms. | 62 |
| abstract_inverted_index.fusing | 27 |
| abstract_inverted_index.higher | 113 |
| abstract_inverted_index.linked | 75 |
| abstract_inverted_index.showed | 98 |
| abstract_inverted_index.Langdon | 35 |
| abstract_inverted_index.Science | 139 |
| abstract_inverted_index.Several | 63 |
| abstract_inverted_index.contain | 70 |
| abstract_inverted_index.domains | 72 |
| abstract_inverted_index.nucleus | 86, 118 |
| abstract_inverted_index.prevent | 124 |
| abstract_inverted_index.protein | 32 |
| abstract_inverted_index.soluble | 83 |
| abstract_inverted_index.through | 10 |
| abstract_inverted_index.trigger | 137 |
| abstract_inverted_index.usually | 82 |
| abstract_inverted_index.Maharana | 95 |
| abstract_inverted_index.cellular | 23 |
| abstract_inverted_index.distinct | 49, 104 |
| abstract_inverted_index.prevents | 21 |
| abstract_inverted_index.randomly | 26 |
| abstract_inverted_index.behaviors | 107 |
| abstract_inverted_index.determine | 103 |
| abstract_inverted_index.different | 44, 109 |
| abstract_inverted_index.diseases. | 78 |
| abstract_inverted_index.secondary | 41 |
| abstract_inverted_index.structure | 42 |
| abstract_inverted_index.together? | 28 |
| abstract_inverted_index.aggregates | 91 |
| abstract_inverted_index.biological | 52 |
| abstract_inverted_index.components | 46 |
| abstract_inverted_index.cytoplasm, | 133 |
| abstract_inverted_index.cytoplasm. | 94 |
| abstract_inverted_index.determines | 47 |
| abstract_inverted_index.locations. | 111 |
| abstract_inverted_index.organelles | 3 |
| abstract_inverted_index.prion-like | 71 |
| abstract_inverted_index.properties | 53 |
| abstract_inverted_index.separation | 13, 106, 126 |
| abstract_inverted_index.Perspective | 16 |
| abstract_inverted_index.RNA-binding | 31 |
| abstract_inverted_index.biophysical | 50 |
| abstract_inverted_index.condensates | 24, 59 |
| abstract_inverted_index.subcellular | 110 |
| abstract_inverted_index.Membraneless | 4 |
| abstract_inverted_index.aggregation. | 138 |
| abstract_inverted_index.compartments | 5 |
| abstract_inverted_index.demonstrated | 38 |
| abstract_inverted_index.liquidliquid | 11 |
| abstract_inverted_index.membraneless | 2 |
| abstract_inverted_index.mislocalized | 130 |
| abstract_inverted_index.pathological | 90 |
| abstract_inverted_index.Polymenidou). | 18 |
| abstract_inverted_index.concentrations | 102, 115, 136 |
| abstract_inverted_index.neurodegenerative | 77 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 99 |
| corresponding_author_ids | https://openalex.org/A5014458109 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I114027177, https://openalex.org/I1338920048 |
| citation_normalized_percentile.value | 0.9983322 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |