Mu-opioid receptor availability in patients with opioid use disorder treated with either methadone or buprenorphine Article Swipe
Jacob G. Dubroff
,
Chia‐Ju Hsieh
,
Hsiaoju Lee
,
Elizabeth Li
,
Alexander Schmitz
,
Timothy Pond
,
Joseph Tung‐Chieh Chang
,
Erin K. Schubert
,
Robert H. Mach
,
Corinde E. Wiers
,
Henry R. Kranzler
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.10.06.25337456
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.10.06.25337456
Methadone (MET) and buprenorphine (BUP)—mu-opioid receptor (MOR) agonists—are efficacious treatments for opioid use disorder (OUD). Using high-sensitivity, long axial field-of-view PET imaging with [ 11 C]carfentanil, we compared MOR availability in 5 MET and 5 BUP patients and 13 healthy controls (HCs) in five brain regions: ventral tegmentum, thalamus, caudate, putamen, and amygdala. MOR availability differed across groups (F 10,34 =5.6, p<0.001) and was lower in BUP patients than HCs across all brain regions (mean reduction=39.1±15.2%; p<0.001), lower in MET patients than HCs in the ventral tegmentum and amygdala (p’s<0.05), and lower in BUP than MET patients in four of five regions (p’s<0.05). MOR availability was inversely related to serum drug levels, linear for MET (R²=0.83, linear) and logarithmic for BUP (R²=0.96). [ 11 C]carfentanil PET may be useful in guiding personalized OUD treatment based on receptor engagement, which differs significantly between the two opioid agonist treatments. Studies are needed to link MOR availability with specific clinical characteristics (e.g., hedonic capacity, MOR agonist-associated weight gain) and OUD treatment outcomes.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.10.06.25337456
- https://www.medrxiv.org/content/medrxiv/early/2025/10/08/2025.10.06.25337456.full.pdf
- OA Status
- green
- References
- 28
- OpenAlex ID
- https://openalex.org/W4414972867
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4414972867Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2025.10.06.25337456Digital Object Identifier
- Title
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Mu-opioid receptor availability in patients with opioid use disorder treated with either methadone or buprenorphineWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-10-08Full publication date if available
- Authors
-
Jacob G. Dubroff, Chia‐Ju Hsieh, Hsiaoju Lee, Elizabeth Li, Alexander Schmitz, Timothy Pond, Joseph Tung‐Chieh Chang, Erin K. Schubert, Robert H. Mach, Corinde E. Wiers, Henry R. KranzlerList of authors in order
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https://doi.org/10.1101/2025.10.06.25337456Publisher landing page
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https://www.medrxiv.org/content/medrxiv/early/2025/10/08/2025.10.06.25337456.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.medrxiv.org/content/medrxiv/early/2025/10/08/2025.10.06.25337456.full.pdfDirect OA link when available
- Cited by
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0Total citation count in OpenAlex
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28Number of works referenced by this work
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| publication_year | 2025 |
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