MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium Article Swipe
Daniel Song
,
Ethan Iverson
,
Logan Kaler
,
Allison Boboltz
,
Margaret A. Scull
,
Gregg A. Duncan
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1126/sciadv.abq5049
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1126/sciadv.abq5049
Secreted mucus is a frontline defense against respiratory infection, enabling the capture and swift removal of infectious or irritating agents from the lungs. Airway mucus is composed of two mucins: mucin 5B (MUC5B) and 5AC (MUC5AC). Together, they form a hydrogel that can be actively transported by cilia along the airway surface. In chronic respiratory diseases, abnormal expression of these mucins is directly implicated in dysfunctional mucus clearance. Yet, the role of each mucin in supporting normal mucus transport remains unclear. Here, we generate human airway epithelial tissue cultures deficient in either MUC5B or MUC5AC to understand their individual contributions to mucus transport. We find that MUC5B and MUC5AC deficiency results in impaired and discoordinated mucociliary transport, respectively, demonstrating the importance of each mucin to airway clearance.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1126/sciadv.abq5049
- https://www.science.org/doi/pdf/10.1126/sciadv.abq5049?download=true
- OA Status
- gold
- Cited By
- 34
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4309958358
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4309958358Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1126/sciadv.abq5049Digital Object Identifier
- Title
-
MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epitheliumWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-23Full publication date if available
- Authors
-
Daniel Song, Ethan Iverson, Logan Kaler, Allison Boboltz, Margaret A. Scull, Gregg A. DuncanList of authors in order
- Landing page
-
https://doi.org/10.1126/sciadv.abq5049Publisher landing page
- PDF URL
-
https://www.science.org/doi/pdf/10.1126/sciadv.abq5049?download=trueDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.science.org/doi/pdf/10.1126/sciadv.abq5049?download=trueDirect OA link when available
- Concepts
-
Mucin, Mucus, Mucociliary clearance, Airway, Respiratory epithelium, Respiratory system, Cilium, Cell biology, Epithelium, Immunology, Biology, Medicine, Pathology, Chemistry, Lung, Anatomy, Internal medicine, Surgery, EcologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
34Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 15, 2024: 11, 2023: 8Per-year citation counts (last 5 years)
- References (count)
-
51Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4309958358 |
|---|---|
| doi | https://doi.org/10.1126/sciadv.abq5049 |
| ids.doi | https://doi.org/10.1126/sciadv.abq5049 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36427316 |
| ids.openalex | https://openalex.org/W4309958358 |
| fwci | 6.96654874 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D055257 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Mucin-5B |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D009079 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Mucociliary Clearance |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D004848 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Epithelium |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D002923 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Cilia |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D012141 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Respiratory Tract Infections |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D055271 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | Mucin 5AC |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D006801 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Humans |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D055257 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Mucin-5B |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D009079 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Mucociliary Clearance |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D004848 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Epithelium |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D002923 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Cilia |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D012141 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Respiratory Tract Infections |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D055271 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Mucin 5AC |
| type | article |
| title | MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium |
| biblio.issue | 47 |
| biblio.volume | 8 |
| biblio.last_page | eabq5049 |
| biblio.first_page | eabq5049 |
| topics[0].id | https://openalex.org/T10665 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9987000226974487 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Cystic Fibrosis Research Advances |
| topics[1].id | https://openalex.org/T10602 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9966999888420105 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Glycosylation and Glycoproteins Research |
| topics[2].id | https://openalex.org/T10549 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9905999898910522 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2740 |
| topics[2].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[2].display_name | Neonatal Respiratory Health Research |
| is_xpac | False |
| apc_list.value | 4500 |
| apc_list.currency | USD |
| apc_list.value_usd | 4500 |
| apc_paid.value | 4500 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 4500 |
| concepts[0].id | https://openalex.org/C179264091 |
| concepts[0].level | 2 |
| concepts[0].score | 0.9446693062782288 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q410862 |
| concepts[0].display_name | Mucin |
| concepts[1].id | https://openalex.org/C2777312293 |
| concepts[1].level | 2 |
| concepts[1].score | 0.9304338693618774 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q3649349 |
| concepts[1].display_name | Mucus |
| concepts[2].id | https://openalex.org/C114682108 |
| concepts[2].level | 3 |
| concepts[2].score | 0.8542754650115967 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1952044 |
| concepts[2].display_name | Mucociliary clearance |
| concepts[3].id | https://openalex.org/C105922876 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6675524711608887 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1423981 |
| concepts[3].display_name | Airway |
| concepts[4].id | https://openalex.org/C87568996 |
| concepts[4].level | 3 |
| concepts[4].score | 0.564739465713501 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1428754 |
| concepts[4].display_name | Respiratory epithelium |
| concepts[5].id | https://openalex.org/C534529494 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5255005359649658 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7891 |
| concepts[5].display_name | Respiratory system |
| concepts[6].id | https://openalex.org/C100094513 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5064128637313843 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q180436 |
| concepts[6].display_name | Cilium |
| concepts[7].id | https://openalex.org/C95444343 |
| concepts[7].level | 1 |
| concepts[7].score | 0.49576982855796814 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[7].display_name | Cell biology |
| concepts[8].id | https://openalex.org/C529295009 |
| concepts[8].level | 2 |
| concepts[8].score | 0.457030713558197 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q41301 |
| concepts[8].display_name | Epithelium |
| concepts[9].id | https://openalex.org/C203014093 |
| concepts[9].level | 1 |
| concepts[9].score | 0.447626531124115 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[9].display_name | Immunology |
| concepts[10].id | https://openalex.org/C86803240 |
| concepts[10].level | 0 |
| concepts[10].score | 0.42659708857536316 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[10].display_name | Biology |
| concepts[11].id | https://openalex.org/C71924100 |
| concepts[11].level | 0 |
| concepts[11].score | 0.358540803194046 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[11].display_name | Medicine |
| concepts[12].id | https://openalex.org/C142724271 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3335118889808655 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[12].display_name | Pathology |
| concepts[13].id | https://openalex.org/C185592680 |
| concepts[13].level | 0 |
| concepts[13].score | 0.3301900029182434 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[13].display_name | Chemistry |
| concepts[14].id | https://openalex.org/C2777714996 |
| concepts[14].level | 2 |
| concepts[14].score | 0.26008689403533936 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7886 |
| concepts[14].display_name | Lung |
| concepts[15].id | https://openalex.org/C105702510 |
| concepts[15].level | 1 |
| concepts[15].score | 0.221112459897995 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q514 |
| concepts[15].display_name | Anatomy |
| concepts[16].id | https://openalex.org/C126322002 |
| concepts[16].level | 1 |
| concepts[16].score | 0.1060309112071991 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[16].display_name | Internal medicine |
| concepts[17].id | https://openalex.org/C141071460 |
| concepts[17].level | 1 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q40821 |
| concepts[17].display_name | Surgery |
| concepts[18].id | https://openalex.org/C18903297 |
| concepts[18].level | 1 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q7150 |
| concepts[18].display_name | Ecology |
| keywords[0].id | https://openalex.org/keywords/mucin |
| keywords[0].score | 0.9446693062782288 |
| keywords[0].display_name | Mucin |
| keywords[1].id | https://openalex.org/keywords/mucus |
| keywords[1].score | 0.9304338693618774 |
| keywords[1].display_name | Mucus |
| keywords[2].id | https://openalex.org/keywords/mucociliary-clearance |
| keywords[2].score | 0.8542754650115967 |
| keywords[2].display_name | Mucociliary clearance |
| keywords[3].id | https://openalex.org/keywords/airway |
| keywords[3].score | 0.6675524711608887 |
| keywords[3].display_name | Airway |
| keywords[4].id | https://openalex.org/keywords/respiratory-epithelium |
| keywords[4].score | 0.564739465713501 |
| keywords[4].display_name | Respiratory epithelium |
| keywords[5].id | https://openalex.org/keywords/respiratory-system |
| keywords[5].score | 0.5255005359649658 |
| keywords[5].display_name | Respiratory system |
| keywords[6].id | https://openalex.org/keywords/cilium |
| keywords[6].score | 0.5064128637313843 |
| keywords[6].display_name | Cilium |
| keywords[7].id | https://openalex.org/keywords/cell-biology |
| keywords[7].score | 0.49576982855796814 |
| keywords[7].display_name | Cell biology |
| keywords[8].id | https://openalex.org/keywords/epithelium |
| keywords[8].score | 0.457030713558197 |
| keywords[8].display_name | Epithelium |
| keywords[9].id | https://openalex.org/keywords/immunology |
| keywords[9].score | 0.447626531124115 |
| keywords[9].display_name | Immunology |
| keywords[10].id | https://openalex.org/keywords/biology |
| keywords[10].score | 0.42659708857536316 |
| keywords[10].display_name | Biology |
| keywords[11].id | https://openalex.org/keywords/medicine |
| keywords[11].score | 0.358540803194046 |
| keywords[11].display_name | Medicine |
| keywords[12].id | https://openalex.org/keywords/pathology |
| keywords[12].score | 0.3335118889808655 |
| keywords[12].display_name | Pathology |
| keywords[13].id | https://openalex.org/keywords/chemistry |
| keywords[13].score | 0.3301900029182434 |
| keywords[13].display_name | Chemistry |
| keywords[14].id | https://openalex.org/keywords/lung |
| keywords[14].score | 0.26008689403533936 |
| keywords[14].display_name | Lung |
| keywords[15].id | https://openalex.org/keywords/anatomy |
| keywords[15].score | 0.221112459897995 |
| keywords[15].display_name | Anatomy |
| keywords[16].id | https://openalex.org/keywords/internal-medicine |
| keywords[16].score | 0.1060309112071991 |
| keywords[16].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.1126/sciadv.abq5049 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2737427234 |
| locations[0].source.issn | 2375-2548 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2375-2548 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Science Advances |
| locations[0].source.host_organization | https://openalex.org/P4310315823 |
| locations[0].source.host_organization_name | American Association for the Advancement of Science |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315823 |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://www.science.org/doi/pdf/10.1126/sciadv.abq5049?download=true |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Science Advances |
| locations[0].landing_page_url | https://doi.org/10.1126/sciadv.abq5049 |
| locations[1].id | pmid:36427316 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Science advances |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36427316 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:9699686 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Sci Adv |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9699686 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5058142687 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2916-6680 |
| authorships[0].author.display_name | Daniel Song |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[0].affiliations[0].raw_affiliation_string | Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA. |
| authorships[0].institutions[0].id | https://openalex.org/I66946132 |
| authorships[0].institutions[0].ror | https://ror.org/047s2c258 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of Maryland, College Park |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Daniel Song |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA. |
| authorships[1].author.id | https://openalex.org/A5082666688 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5815-8079 |
| authorships[1].author.display_name | Ethan Iverson |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA. |
| authorships[1].institutions[0].id | https://openalex.org/I66946132 |
| authorships[1].institutions[0].ror | https://ror.org/047s2c258 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of Maryland, College Park |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ethan Iverson |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA. |
| authorships[2].author.id | https://openalex.org/A5041149072 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6502-5773 |
| authorships[2].author.display_name | Logan Kaler |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[2].affiliations[0].raw_affiliation_string | Biophysics Program, University of Maryland, College Park, MD 20742, USA. |
| authorships[2].institutions[0].id | https://openalex.org/I66946132 |
| authorships[2].institutions[0].ror | https://ror.org/047s2c258 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of Maryland, College Park |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Logan Kaler |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Biophysics Program, University of Maryland, College Park, MD 20742, USA. |
| authorships[3].author.id | https://openalex.org/A5035387362 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-4203-5928 |
| authorships[3].author.display_name | Allison Boboltz |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[3].affiliations[0].raw_affiliation_string | Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA. |
| authorships[3].institutions[0].id | https://openalex.org/I66946132 |
| authorships[3].institutions[0].ror | https://ror.org/047s2c258 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of Maryland, College Park |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Allison Boboltz |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA. |
| authorships[4].author.id | https://openalex.org/A5018254763 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-6860-2468 |
| authorships[4].author.display_name | Margaret A. Scull |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA. |
| authorships[4].institutions[0].id | https://openalex.org/I66946132 |
| authorships[4].institutions[0].ror | https://ror.org/047s2c258 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of Maryland, College Park |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Margaret A. Scull |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA. |
| authorships[5].author.id | https://openalex.org/A5081378279 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6811-1327 |
| authorships[5].author.display_name | Gregg A. Duncan |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I66946132 |
| authorships[5].affiliations[0].raw_affiliation_string | Biophysics Program, University of Maryland, College Park, MD 20742, USA. |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I66946132 |
| authorships[5].affiliations[1].raw_affiliation_string | Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA. |
| authorships[5].institutions[0].id | https://openalex.org/I66946132 |
| authorships[5].institutions[0].ror | https://ror.org/047s2c258 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I66946132 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | University of Maryland, College Park |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Gregg A. Duncan |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Biophysics Program, University of Maryland, College Park, MD 20742, USA., Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.science.org/doi/pdf/10.1126/sciadv.abq5049?download=true |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10665 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9987000226974487 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Cystic Fibrosis Research Advances |
| related_works | https://openalex.org/W69413871, https://openalex.org/W1914691072, https://openalex.org/W2046545314, https://openalex.org/W4211140651, https://openalex.org/W2430545656, https://openalex.org/W1974477809, https://openalex.org/W2889319600, https://openalex.org/W2999769701, https://openalex.org/W2051939473, https://openalex.org/W4309958358 |
| cited_by_count | 34 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 15 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 11 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 8 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1126/sciadv.abq5049 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2737427234 |
| best_oa_location.source.issn | 2375-2548 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2375-2548 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Science Advances |
| best_oa_location.source.host_organization | https://openalex.org/P4310315823 |
| best_oa_location.source.host_organization_name | American Association for the Advancement of Science |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310315823 |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://www.science.org/doi/pdf/10.1126/sciadv.abq5049?download=true |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Science Advances |
| best_oa_location.landing_page_url | https://doi.org/10.1126/sciadv.abq5049 |
| primary_location.id | doi:10.1126/sciadv.abq5049 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2737427234 |
| primary_location.source.issn | 2375-2548 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2375-2548 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Science Advances |
| primary_location.source.host_organization | https://openalex.org/P4310315823 |
| primary_location.source.host_organization_name | American Association for the Advancement of Science |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315823 |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://www.science.org/doi/pdf/10.1126/sciadv.abq5049?download=true |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Science Advances |
| primary_location.landing_page_url | https://doi.org/10.1126/sciadv.abq5049 |
| publication_date | 2022-11-23 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2101594367, https://openalex.org/W2013503901, https://openalex.org/W1978811535, https://openalex.org/W3093959511, https://openalex.org/W2788749062, https://openalex.org/W2552046709, https://openalex.org/W2750856487, https://openalex.org/W2138914111, https://openalex.org/W1988327627, https://openalex.org/W2548660947, https://openalex.org/W2075070043, https://openalex.org/W2033228659, https://openalex.org/W2965168049, https://openalex.org/W2765851819, https://openalex.org/W3199753407, https://openalex.org/W2895500801, https://openalex.org/W2008440267, https://openalex.org/W2023304501, https://openalex.org/W2904652511, https://openalex.org/W2118132981, https://openalex.org/W2350198724, https://openalex.org/W1747652534, https://openalex.org/W2807445466, https://openalex.org/W2787852705, https://openalex.org/W2331897823, https://openalex.org/W3033188341, https://openalex.org/W2130318026, https://openalex.org/W3153357536, https://openalex.org/W3000186698, https://openalex.org/W1603039152, https://openalex.org/W2342250425, https://openalex.org/W2152428615, https://openalex.org/W4205461726, https://openalex.org/W3027504704, https://openalex.org/W3047795789, https://openalex.org/W2170183171, https://openalex.org/W3092321013, https://openalex.org/W2909464755, https://openalex.org/W2889620461, https://openalex.org/W2753261511, https://openalex.org/W4282922193, https://openalex.org/W2433754406, https://openalex.org/W1967388355, https://openalex.org/W2981152897, https://openalex.org/W2015807262, https://openalex.org/W4226096259, https://openalex.org/W3202762110, https://openalex.org/W4226082839, https://openalex.org/W4299614483, https://openalex.org/W4229039504, https://openalex.org/W4206482915 |
| referenced_works_count | 51 |
| abstract_inverted_index.a | 3, 39 |
| abstract_inverted_index.5B | 31 |
| abstract_inverted_index.In | 52 |
| abstract_inverted_index.We | 103 |
| abstract_inverted_index.be | 43 |
| abstract_inverted_index.by | 46 |
| abstract_inverted_index.in | 64, 74, 90, 111 |
| abstract_inverted_index.is | 2, 25, 61 |
| abstract_inverted_index.of | 15, 27, 58, 71, 121 |
| abstract_inverted_index.or | 17, 93 |
| abstract_inverted_index.to | 95, 100, 124 |
| abstract_inverted_index.we | 82 |
| abstract_inverted_index.5AC | 34 |
| abstract_inverted_index.and | 12, 33, 107, 113 |
| abstract_inverted_index.can | 42 |
| abstract_inverted_index.the | 10, 21, 49, 69, 119 |
| abstract_inverted_index.two | 28 |
| abstract_inverted_index.Yet, | 68 |
| abstract_inverted_index.each | 72, 122 |
| abstract_inverted_index.find | 104 |
| abstract_inverted_index.form | 38 |
| abstract_inverted_index.from | 20 |
| abstract_inverted_index.role | 70 |
| abstract_inverted_index.that | 41, 105 |
| abstract_inverted_index.they | 37 |
| abstract_inverted_index.Here, | 81 |
| abstract_inverted_index.MUC5B | 92, 106 |
| abstract_inverted_index.along | 48 |
| abstract_inverted_index.cilia | 47 |
| abstract_inverted_index.human | 84 |
| abstract_inverted_index.mucin | 30, 73, 123 |
| abstract_inverted_index.mucus | 1, 24, 66, 77, 101 |
| abstract_inverted_index.swift | 13 |
| abstract_inverted_index.their | 97 |
| abstract_inverted_index.these | 59 |
| abstract_inverted_index.Airway | 23 |
| abstract_inverted_index.MUC5AC | 94, 108 |
| abstract_inverted_index.agents | 19 |
| abstract_inverted_index.airway | 50, 85, 125 |
| abstract_inverted_index.either | 91 |
| abstract_inverted_index.lungs. | 22 |
| abstract_inverted_index.mucins | 60 |
| abstract_inverted_index.normal | 76 |
| abstract_inverted_index.tissue | 87 |
| abstract_inverted_index.(MUC5B) | 32 |
| abstract_inverted_index.against | 6 |
| abstract_inverted_index.capture | 11 |
| abstract_inverted_index.chronic | 53 |
| abstract_inverted_index.defense | 5 |
| abstract_inverted_index.mucins: | 29 |
| abstract_inverted_index.remains | 79 |
| abstract_inverted_index.removal | 14 |
| abstract_inverted_index.results | 110 |
| abstract_inverted_index.Secreted | 0 |
| abstract_inverted_index.abnormal | 56 |
| abstract_inverted_index.actively | 44 |
| abstract_inverted_index.composed | 26 |
| abstract_inverted_index.cultures | 88 |
| abstract_inverted_index.directly | 62 |
| abstract_inverted_index.enabling | 9 |
| abstract_inverted_index.generate | 83 |
| abstract_inverted_index.hydrogel | 40 |
| abstract_inverted_index.impaired | 112 |
| abstract_inverted_index.surface. | 51 |
| abstract_inverted_index.unclear. | 80 |
| abstract_inverted_index.(MUC5AC). | 35 |
| abstract_inverted_index.Together, | 36 |
| abstract_inverted_index.deficient | 89 |
| abstract_inverted_index.diseases, | 55 |
| abstract_inverted_index.frontline | 4 |
| abstract_inverted_index.transport | 78 |
| abstract_inverted_index.clearance. | 67, 126 |
| abstract_inverted_index.deficiency | 109 |
| abstract_inverted_index.epithelial | 86 |
| abstract_inverted_index.expression | 57 |
| abstract_inverted_index.implicated | 63 |
| abstract_inverted_index.importance | 120 |
| abstract_inverted_index.individual | 98 |
| abstract_inverted_index.infection, | 8 |
| abstract_inverted_index.infectious | 16 |
| abstract_inverted_index.irritating | 18 |
| abstract_inverted_index.supporting | 75 |
| abstract_inverted_index.transport, | 116 |
| abstract_inverted_index.transport. | 102 |
| abstract_inverted_index.understand | 96 |
| abstract_inverted_index.mucociliary | 115 |
| abstract_inverted_index.respiratory | 7, 54 |
| abstract_inverted_index.transported | 45 |
| abstract_inverted_index.contributions | 99 |
| abstract_inverted_index.demonstrating | 118 |
| abstract_inverted_index.dysfunctional | 65 |
| abstract_inverted_index.respectively, | 117 |
| abstract_inverted_index.discoordinated | 114 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 99 |
| corresponding_author_ids | https://openalex.org/A5018254763, https://openalex.org/A5081378279 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I66946132 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.96961778 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |