Mucin-mimetic action of capsaicin improves high fat diet-induced gut barrier dysfunction in mice colon Article Swipe
Vijay Kumar
,
Vibhu Kumar
,
Neha Mahajan
,
Jasleen Kaur
,
Kirti Devi
,
Ravinder Naik Dharavath
,
Ravindra Pal Singh
,
Kanthi Kiran Kondepudi
,
Mahendra Bishnoi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.08.04.455153
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.08.04.455153
The gut barrier – including tight junction proteins and mucus layers, is the first line of defense against physical, chemical, or pathogenic incursions. This barrier is compromised in various health disorders. Capsaicin, a dietary agonist of Transient receptor potential vanilloid 1 (TRPV1) channel, is reported to alleviate the complications of obesity. While its mode of action is well established to enhance energy expenditure, metabolism and prevent dysbiosis, the more local effects on the host gut – particularly the gut barrier and mucus system remain elusive. We employed a diet-induced obesity model to investigate the effect of capsaicin on the gut barrier and mucus production and to understand the involvement of mucus, bacteria, and TRPV1 in these phenomena. Mucin feeding reflected most of the effects produced by capsaicin, indicating that mucus modulation by capsaicin plays a crucial role in its anti-obesity effects. Capsaicin, bacteria and the host mucus system seem to act in a cyclic cascade involving TRPV1, which can be activated by capsaicin and various bacteria. These findings provide new insight into the role of TRPV1 in maintaining a healthy gut environment. HIGHLIGHTS Exogenous mucin feeding produced anti-obesity effects similar to capsaicin in mice. Mucin and capsaicin improved TJP expression, intestinal permeability and gut microbial diversity. Capsaicin modulated bacterial diversity in vitro , independently of the host. Probiotic bacteria and butyrate activated TRPV1 in transfected HEK cells. Anti-obesity action of capsaicin is not exclusive to TRPV1 agonism. Capsaicin’s action as colonic mucus secretagogue – plays a crucial part in its anti-obesity benefits.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.08.04.455153
- https://www.biorxiv.org/content/biorxiv/early/2021/08/06/2021.08.04.455153.full.pdf
- OA Status
- green
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3190769423
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- OpenAlex ID
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https://openalex.org/W3190769423Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.08.04.455153Digital Object Identifier
- Title
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Mucin-mimetic action of capsaicin improves high fat diet-induced gut barrier dysfunction in mice colonWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-08-06Full publication date if available
- Authors
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Vijay Kumar, Vibhu Kumar, Neha Mahajan, Jasleen Kaur, Kirti Devi, Ravinder Naik Dharavath, Ravindra Pal Singh, Kanthi Kiran Kondepudi, Mahendra BishnoiList of authors in order
- Landing page
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https://doi.org/10.1101/2021.08.04.455153Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2021/08/06/2021.08.04.455153.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2021/08/06/2021.08.04.455153.full.pdfDirect OA link when available
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Capsaicin, TRPV1, Mucus, Mucin, Dysbiosis, Gut flora, Chemistry, Biology, Microbiology, Cell biology, Transient receptor potential channel, Receptor, Immunology, Biochemistry, EcologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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58Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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