Mucosal impedance as a diagnostic tool for gastroesophageal reflux disease: an update for clinicians Article Swipe
Matthew Marshall‐Webb
,
Jennifer C. Myers
,
David I. Watson
,
Tim Bright
,
Taher Omari
,
Sarah K. Thompson
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/dote/doae037
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/dote/doae037
Mucosal impedance is a marker of esophageal mucosal integrity and a novel technique for assessing esophageal function and pathology. This article highlights its development and clinical application for gastroesophageal reflux disease (GERD), Barrett’s esophagus, and eosinophilic esophagitis. A narrative review of key publications describing the development and use of mucosal impedance in clinical practice was conducted. A low mean nocturnal baseline impedance (MNBI) has been shown to be an independent predictor of response to anti-reflux therapy. MNBI predicts medication-responsive heartburn better than distal esophageal acid exposure time. Patients with equivocal evidence of GERD using conventional methods, with a low MNBI, had an improvement in symptoms following the initiation of PPI therapy compared to those with a normal MNBI. A similar trend was seen in a post fundoplication cohort. Strong clinical utility for the use of mucosal impedance in assessing eosinophilic esophagitis has been repeatedly demonstrated; however, there is minimal direction for application in Barrett’s esophagus. The authors conclude that mucosal impedance has potential clinical utility for the assessment and diagnosis of GERD, particularly when conventional investigations have yielded equivocal results.
Related Topics
Concepts
Medicine
GERD
Eosinophilic esophagitis
Internal medicine
Reflux
Heartburn
Esophagus
Gastroenterology
Disease
Esophageal pH monitoring
Cohort
Nerd
Esophagitis
Reflux esophagitis
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1093/dote/doae037
- OA Status
- hybrid
- Cited By
- 5
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4395699516
All OpenAlex metadata
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https://openalex.org/W4395699516Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/dote/doae037Digital Object Identifier
- Title
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Mucosal impedance as a diagnostic tool for gastroesophageal reflux disease: an update for cliniciansWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-04-26Full publication date if available
- Authors
-
Matthew Marshall‐Webb, Jennifer C. Myers, David I. Watson, Tim Bright, Taher Omari, Sarah K. ThompsonList of authors in order
- Landing page
-
https://doi.org/10.1093/dote/doae037Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1093/dote/doae037Direct OA link when available
- Concepts
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Medicine, GERD, Eosinophilic esophagitis, Internal medicine, Reflux, Heartburn, Esophagus, Gastroenterology, Disease, Esophageal pH monitoring, Cohort, Nerd, Esophagitis, Reflux esophagitisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5Per-year citation counts (last 5 years)
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22Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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