Mucus, Microbiomes and Pulmonary Disease Article Swipe
Oliver W. Meldrum
,
Sanjay H. Chotirmall
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines9060675
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines9060675
The respiratory tract harbors a stable and diverse microbial population within an extracellular mucus layer. Mucus provides a formidable defense against infection and maintaining healthy mucus is essential to normal pulmonary physiology, promoting immune tolerance and facilitating a healthy, commensal lung microbiome that can be altered in association with chronic respiratory disease. How one maintains a specialized (healthy) microbiome that resists significant fluctuation remains unknown, although smoking, diet, antimicrobial therapy, and infection have all been observed to influence microbial lung homeostasis. In this review, we outline the specific role of polymerizing mucin, a key functional component of the mucus layer that changes during pulmonary disease. We discuss strategies by which mucin feed and spatial orientation directly influence microbial behavior and highlight how a compromised mucus layer gives rise to inflammation and microbial dysbiosis. This emerging field of respiratory research provides fresh opportunities to examine mucus, and its function as predictors of infection risk or disease progression and severity across a range of chronic pulmonary disease states and consider new perspectives in the development of mucolytic treatments.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines9060675
- https://www.mdpi.com/2227-9059/9/6/675/pdf?version=1623809204
- OA Status
- gold
- Cited By
- 42
- References
- 151
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3168727141
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3168727141Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomedicines9060675Digital Object Identifier
- Title
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Mucus, Microbiomes and Pulmonary DiseaseWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-06-13Full publication date if available
- Authors
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Oliver W. Meldrum, Sanjay H. ChotirmallList of authors in order
- Landing page
-
https://doi.org/10.3390/biomedicines9060675Publisher landing page
- PDF URL
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https://www.mdpi.com/2227-9059/9/6/675/pdf?version=1623809204Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2227-9059/9/6/675/pdf?version=1623809204Direct OA link when available
- Concepts
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Mucus, Microbiome, Cystic fibrosis, Mucin, Biology, Immunology, Dysbiosis, Lung, Disease, Respiratory tract, Inflammation, Immune system, Population, Respiratory system, Microbiology, Medicine, Bioinformatics, Pathology, Internal medicine, Ecology, Genetics, Environmental health, Biochemistry, AnatomyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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42Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 15, 2023: 8, 2022: 9, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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151Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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