Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours Article Swipe
Flavia Venetucci Gouveia
,
Jürgen Germann
,
Gavin J.B. Elias
,
Alexandre Boutet
,
Aaron Loh
,
Adriana Lucia López Ríos
,
Cristina V. Torres
,
William Omar Contreras López
,
Raquel Chacon Ruiz Martinez
,
Erich Talamoni Fonoff
,
Juan Carlos Benedetti‐Isaac
,
Peter Giacobbe
,
Pablo M Arango Pava
,
Han Yan
,
George M. Ibrahim
,
Nir Lipsman
,
Andrés M. Lozano
,
Clement Hamani
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.84566
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.84566
Deep brain stimulation targeting the posterior hypothalamus (pHyp-DBS) is being investigated as a treatment for refractory aggressive behavior, but its mechanisms of action remain elusive. We conducted an integrated imaging analysis of a large multi-centre dataset, incorporating volume of activated tissue modeling, probabilistic mapping, normative connectomics, and atlas-derived transcriptomics. Ninety-one percent of the patients responded positively to treatment, with a more striking improvement recorded in the pediatric population. Probabilistic mapping revealed an optimized surgical target within the posterior-inferior-lateral region of the posterior hypothalamic area. Normative connectomic analyses identified fiber tracts and functionally connected with brain areas associated with sensorimotor function, emotional regulation, and monoamine production. Functional connectivity between the target, periaqueductal gray and key limbic areas – together with patient age – were highly predictive of treatment outcome. Transcriptomic analysis showed that genes involved in mechanisms of aggressive behavior, neuronal communication, plasticity and neuroinflammation might underlie this functional network.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.84566
- OA Status
- gold
- Cited By
- 20
- References
- 107
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4377219918
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4377219918Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.84566Digital Object Identifier
- Title
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Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behavioursWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-05-15Full publication date if available
- Authors
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Flavia Venetucci Gouveia, Jürgen Germann, Gavin J.B. Elias, Alexandre Boutet, Aaron Loh, Adriana Lucia López Ríos, Cristina V. Torres, William Omar Contreras López, Raquel Chacon Ruiz Martinez, Erich Talamoni Fonoff, Juan Carlos Benedetti‐Isaac, Peter Giacobbe, Pablo M Arango Pava, Han Yan, George M. Ibrahim, Nir Lipsman, Andrés M. Lozano, Clement HamaniList of authors in order
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https://doi.org/10.7554/elife.84566Publisher landing page
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://doi.org/10.7554/elife.84566Direct OA link when available
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Gene, Stimulation, Biology, Neuroscience, Computational biology, Genetics, PsychologyTop concepts (fields/topics) attached by OpenAlex
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20Total citation count in OpenAlex
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2025: 7, 2024: 11, 2023: 2Per-year citation counts (last 5 years)
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107Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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