Multi-omics dissection of super-enhancer heterogeneity reveals subtype-specific transcriptional drivers in triple-negative breast cancer Article Swipe
Zhiyi Lu
,
Zhenchang Wang
,
Wenyong Zhu
,
Shuyang Cai
,
Xiao Sun
,
Hao Huang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.ygeno.2025.111097
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.ygeno.2025.111097
As a clinically heterogeneous breast cancer subtype, triple-negative breast cancer (TNBC) currently lacks effective targeted therapies. The subtype-specific heterogeneity of tumor phenotypes and gene expression programs poses challenges for the treatment of TNBC. However, while progress has been made in understanding the epigenetic and molecular mechanisms of TNBC, studies on the role of super-enhancers (SEs) in TNBC remain limited, particularly in the exploration of preclinical models at the subtype level. This study constructed a transcriptome-driven subtype classifier for cell lines, characterized epigenetic heterogeneity in the Fudan University Shanghai Cancer Center (FUSCC) TNBC subtypes, and mapped subtype-specific super-enhancers landscape. We revealed SE-mediated regulatory mechanisms underlying subtype divergence and proposed epigenetically informed therapeutic targets. We identified ZNF703 as a regulator in the LAR subtype and NesBCL11A in the BLIS subtype, both with clinical implications. This research offers new insights into TNBC's molecular mechanisms and potential targets for subtype-specific therapies.
Related Topics
Concepts
Biology
Triple-negative breast cancer
Enhancer
Breast cancer
Computational biology
Cancer
Genetics
Gene
Bioinformatics
Cancer research
Gene expression
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ygeno.2025.111097
- OA Status
- gold
- References
- 59
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413162299
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413162299Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.ygeno.2025.111097Digital Object Identifier
- Title
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Multi-omics dissection of super-enhancer heterogeneity reveals subtype-specific transcriptional drivers in triple-negative breast cancerWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-13Full publication date if available
- Authors
-
Zhiyi Lu, Zhenchang Wang, Wenyong Zhu, Shuyang Cai, Xiao Sun, Hao HuangList of authors in order
- Landing page
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https://doi.org/10.1016/j.ygeno.2025.111097Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.ygeno.2025.111097Direct OA link when available
- Concepts
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Biology, Triple-negative breast cancer, Enhancer, Breast cancer, Computational biology, Cancer, Genetics, Gene, Bioinformatics, Cancer research, Gene expressionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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59Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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