Multi-Omics of Tomato Glandular Trichomes Reveals Distinct Features of Central Carbon Metabolism Supporting High Productivity of Specialized Metabolites Article Swipe

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Gerd U. Balcke , Stefan Bennewitz , Nick Bergau , Benedikt Athmer , Anja Henning , Petra Majovsky , José M. Jiménez‐Gómez , Wolfgang Hoehenwarter , Alain Tissier ·

YOU? · · 2017 · Open Access · · DOI: https://doi.org/10.1105/tpc.17.00060

Glandular trichomes are metabolic cell factories with the capacity to produce large quantities of secondary metabolites. Little is known about the connection between central carbon metabolism and metabolic productivity for secondary metabolites in glandular trichomes. To address this gap in our knowledge, we performed comparative metabolomics, transcriptomics, proteomics, and ¹³C-labeling of type VI glandular trichomes and leaves from a cultivated (Solanum lycopersicum LA4024) and a wild (Solanum habrochaites LA1777) tomato accession. Specific features of glandular trichomes that drive the formation of secondary metabolites could be identified. Tomato type VI trichomes are photosynthetic but acquire their carbon essentially from leaf sucrose. The energy and reducing power from photosynthesis are used to support the biosynthesis of secondary metabolites, while the comparatively reduced Calvin-Benson-Bassham cycle activity may be involved in recycling metabolic CO₂ Glandular trichomes cope with oxidative stress by producing high levels of polyunsaturated fatty acids, oxylipins, and glutathione. Finally, distinct mechanisms are present in glandular trichomes to increase the supply of precursors for the isoprenoid pathways. Particularly, the citrate-malate shuttle supplies cytosolic acetyl-CoA and plastidic glycolysis and malic enzyme support the formation of plastidic pyruvate. A model is proposed on how glandular trichomes achieve high metabolic productivity.

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Computational Biology

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Biology Trichome Productivity Metabolism Botany Computational biology Biotechnology Biochemistry Macroeconomics Economics

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Type: article
Language: en
Landing Page: https://doi.org/10.1105/tpc.17.00060
PDF: http://www.plantcell.org/content/plantcell/29/5/960.full.pdf
OA Status: bronze
Cited By: 197
References: 79
Related Works: 10
OpenAlex ID: https://openalex.org/W2607292053

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DOI: https://doi.org/10.1105/tpc.17.00060

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Title: Multi-Omics of Tomato Glandular Trichomes Reveals Distinct Features of Central Carbon Metabolism Supporting High Productivity of Specialized Metabolites

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Type: article

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Language: en

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Publication year: 2017

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Publication date: 2017-04-13

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Authors: Gerd U. Balcke, Stefan Bennewitz, Nick Bergau, Benedikt Athmer, Anja Henning, Petra Majovsky, José M. Jiménez‐Gómez, Wolfgang Hoehenwarter, Alain Tissier

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Landing page: https://doi.org/10.1105/tpc.17.00060

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PDF URL: https://www.plantcell.org/content/plantcell/29/5/960.full.pdf

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OA status: bronze

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Concepts: Biology, Trichome, Productivity, Metabolism, Botany, Computational biology, Biotechnology, Biochemistry, Macroeconomics, Economics

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Cited by: 197

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Citations by year (recent): 2025: 20, 2024: 35, 2023: 12, 2022: 32, 2021: 31

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