Multi-way modelling of oral microbial dynamics and host-microbiome interactions during induced gingivitis Article Swipe
Geert Roelof van der Ploeg
,
Bernd W. Brandt
,
Bart J. F. Keijser
,
Monique H. van der Veen
,
C.M.C. Volgenant
,
Egija Zaura
,
Age K. Smilde
,
Johan A. Westerhuis
,
Anna Heintz‐Buschart
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41522-024-00565-x
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41522-024-00565-x
Gingivitis-the inflammation of the gums-is a reversible stage of periodontal disease. It is caused by dental plaque formation due to poor oral hygiene. However, gingivitis susceptibility involves a complex set of interactions between the oral microbiome, oral metabolome and the host. In this study, we investigated the dynamics of the oral microbiome and its interactions with the salivary metabolome during experimental gingivitis in a cohort of 41 systemically healthy participants. We use Parallel Factor Analysis (PARAFAC), which is a multi-way generalization of Principal Component Analysis (PCA) that can model the variability in the response due to subjects, variables and time. Using the modelled responses, we identified microbial subcommunities with similar dynamics that connect to the magnitude of the gingivitis response. By performing high level integration of the predicted metabolic functions of the microbiome and salivary metabolome, we identified pathways of interest that describe the changing proportions of Gram-positive and Gram-negative microbiota, variation in anaerobic bacteria, biofilm formation and virulence.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41522-024-00565-x
- OA Status
- gold
- Cited By
- 6
- References
- 85
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402643710
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402643710Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41522-024-00565-xDigital Object Identifier
- Title
-
Multi-way modelling of oral microbial dynamics and host-microbiome interactions during induced gingivitisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-09-19Full publication date if available
- Authors
-
Geert Roelof van der Ploeg, Bernd W. Brandt, Bart J. F. Keijser, Monique H. van der Veen, C.M.C. Volgenant, Egija Zaura, Age K. Smilde, Johan A. Westerhuis, Anna Heintz‐BuschartList of authors in order
- Landing page
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https://doi.org/10.1038/s41522-024-00565-xPublisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1038/s41522-024-00565-xDirect OA link when available
- Concepts
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Microbiome, Oral Microbiome, Gingivitis, Dynamics (music), Host (biology), Biology, Dentistry, Medicine, Ecology, Psychology, Bioinformatics, PedagogyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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85Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2158135241, https://openalex.org/W2956655325, https://openalex.org/W2091433858, https://openalex.org/W2037854146, https://openalex.org/W3022287185, https://openalex.org/W2054068403, https://openalex.org/W4211174507, https://openalex.org/W3113166771, https://openalex.org/W2808996141, https://openalex.org/W2550762460, https://openalex.org/W2159104664, https://openalex.org/W2039585351, https://openalex.org/W2130494189, https://openalex.org/W137233685, https://openalex.org/W2536687083, https://openalex.org/W2123007356, https://openalex.org/W2998951868, https://openalex.org/W2282442395, https://openalex.org/W3133978115, https://openalex.org/W2007843797, https://openalex.org/W2529156797, https://openalex.org/W2125265838, https://openalex.org/W2913441481, https://openalex.org/W2190127445, https://openalex.org/W1877640717, https://openalex.org/W2515460693, https://openalex.org/W2000215628, https://openalex.org/W2119741678, https://openalex.org/W1994219736, https://openalex.org/W1512018163, https://openalex.org/W2065536131, https://openalex.org/W2128769815, https://openalex.org/W2126218947, https://openalex.org/W2117522399, https://openalex.org/W2044251889, https://openalex.org/W2110082875, https://openalex.org/W3031621681, https://openalex.org/W2591941343, https://openalex.org/W2083637865, https://openalex.org/W2155639125, https://openalex.org/W2050016299, https://openalex.org/W1480059945, https://openalex.org/W2117420919, https://openalex.org/W177451543, https://openalex.org/W2891451326, https://openalex.org/W2953983865, https://openalex.org/W2149217945, https://openalex.org/W2579544737, https://openalex.org/W2024661770, https://openalex.org/W2100977464, https://openalex.org/W2131757650, https://openalex.org/W1927570869, https://openalex.org/W1994937222, https://openalex.org/W2978578629, https://openalex.org/W2937739421, https://openalex.org/W1556343729, https://openalex.org/W4304893376, https://openalex.org/W2954109429, https://openalex.org/W1641045756, https://openalex.org/W4382401235, https://openalex.org/W2107465071, https://openalex.org/W2577168313, https://openalex.org/W2568664288, https://openalex.org/W2117457769, https://openalex.org/W2401404581, https://openalex.org/W1980270094, https://openalex.org/W2168257591, https://openalex.org/W3096828292, https://openalex.org/W4294216483, https://openalex.org/W2107228383, https://openalex.org/W1998090455, https://openalex.org/W2904250115, https://openalex.org/W2769542288, https://openalex.org/W2085946009, https://openalex.org/W2115699469, https://openalex.org/W2045204781, https://openalex.org/W2036897871, https://openalex.org/W3081657721, https://openalex.org/W4396642089, https://openalex.org/W180738345, https://openalex.org/W4234277801, https://openalex.org/W2118479465, https://openalex.org/W2809458634, https://openalex.org/W2159482845, https://openalex.org/W2522284601 |
| referenced_works_count | 85 |
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| abstract_inverted_index.41 | 66 |
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| abstract_inverted_index.and | 38, 52, 98, 133, 148, 157 |
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| abstract_inverted_index.due | 18, 94 |
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| abstract_inverted_index.set | 29 |
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| abstract_inverted_index.describe | 142 |
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| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.7699999809265137 |
| sustainable_development_goals[0].display_name | Zero hunger |
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| citation_normalized_percentile.is_in_top_10_percent | True |