Multilayer Adjuvanted Influenza Protein Nanoparticles Improve Intranasal Delivery and Antigen-Specific Immunity Article Swipe
Jaeyoung Park
,
Thomas Pho
,
Noopur Bhatnagar
,
D. Linh
,
Mariela R. Rodriguez-Otero
,
Surya Sekhar Pal
,
Chau Thuy Tien Le
,
Steven Jenison
,
Chenyu Li
,
Gemma E. May
,
Marisa Arioka
,
Sang‐Moo Kang
,
Julie A. Champion
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.4c14735
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.4c14735
Intranasal vaccination is a desired route for protection against influenza viruses by mucosal and systemic immunity. However, the nasal mucosa impedes the intranasal delivery of vaccines. Here, we formulated layer-by-layer (LBL) influenza vaccine nanoparticles for effective intranasal delivery by coating them with alternating mucoadhesive cationic chitosan and muco-inert anionic CpG adjuvants. The nanoparticle cores were formed by desolvating influenza M2e antigen and coating it with hemagglutinin (HA) antigen via biotin-streptavidin conjugation. LBL modification promoted nasal delivery and interaction with the resident immune cells. Intranasal administration with LBL nanoparticles significantly improved cellular and humoral immune responses against HA and M2e including high IgA titers, a hallmark of potent mucosal immunity and persistence of immune responses. Distinct trends for antigen-specific immune responses were observed for different routes of vaccination. The enhanced immune responses conferred mice protection against the influenza challenge and prominently reduced viral titers, demonstrating the effectiveness of intranasal LBL vaccine nanoparticles.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsnano.4c14735
- OA Status
- hybrid
- Cited By
- 5
- References
- 114
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407594881
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407594881Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acsnano.4c14735Digital Object Identifier
- Title
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Multilayer Adjuvanted Influenza Protein Nanoparticles Improve Intranasal Delivery and Antigen-Specific ImmunityWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-02-15Full publication date if available
- Authors
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Jaeyoung Park, Thomas Pho, Noopur Bhatnagar, D. Linh, Mariela R. Rodriguez-Otero, Surya Sekhar Pal, Chau Thuy Tien Le, Steven Jenison, Chenyu Li, Gemma E. May, Marisa Arioka, Sang‐Moo Kang, Julie A. ChampionList of authors in order
- Landing page
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https://doi.org/10.1021/acsnano.4c14735Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1021/acsnano.4c14735Direct OA link when available
- Concepts
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Nasal administration, Antigen, Immunity, Virology, Nanoparticle, Medicine, Immunology, Immune system, Nanotechnology, Materials scienceTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 5Per-year citation counts (last 5 years)
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114Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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