Multimodal Neuroimaging of the Effect of Serotonergic Psychedelics on the Brain Article Swipe
YOU?
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· 2024
· Open Access
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· DOI: https://doi.org/10.3174/ajnr.a8118
The neurobiological mechanisms underpinning psychiatric disorders such as treatment-resistant major depression, post-traumatic stress disorder, and substance use disorders, remain unknown. Psychedelic compounds, such as psilocybin, lysergic acid diethylamide, and N,N-dimethyltryptamine, have emerged as potential therapies for these disorders because of their hypothesized ability to induce neuroplastic effects and alter functional networks in the brain. Yet, the mechanisms underpinning the neurobiological treatment response remain obscure. Quantitative neuroimaging is uniquely positioned to provide insight into the neurobiological mechanisms of these emerging therapies and quantify the patient treatment response. This review aims to synthesize our current state-of-the-art understanding of the functional changes occurring in the brain following psilocybin, lysergic acid diethylamide, or N,N-dimethyltryptamine administration in human participants with fMRI and PET. We further aim to disseminate our understanding of psychedelic compounds as they relate to neuroimaging with the goal of improved diagnostics and treatment of neuropsychiatric illness.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3174/ajnr.a8118
- OA Status
- hybrid
- Cited By
- 3
- References
- 69
- Related Works
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- OpenAlex ID
- https://openalex.org/W4391838869
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391838869Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3174/ajnr.a8118Digital Object Identifier
- Title
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Multimodal Neuroimaging of the Effect of Serotonergic Psychedelics on the BrainWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-02-15Full publication date if available
- Authors
-
Paloma C. Frautschi, Ajay Paul Singh, Nicholas A. Stowe, John‐Paul J. YuList of authors in order
- Landing page
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https://doi.org/10.3174/ajnr.a8118Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.3174/ajnr.a8118Direct OA link when available
- Concepts
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Psilocybin, Hallucinogen, Neuroimaging, Serotonergic, Neuroscience, Lysergic acid diethylamide, Functional neuroimaging, Medicine, Default mode network, Psychology, Psychiatry, Functional magnetic resonance imaging, Serotonin, Receptor, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
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69Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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